Potential role of Chinese medicine nanoparticles to treat coronary artery disease

Yang, Rongyuan; Gu, Yingming; Qin, Jinying; Liu, Qingqing; Liu, Qing

doi:10.1016/j.heliyon.2023.e19766

Cited by 1 publication

(2 citation statements)

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“…In addition, understanding the metabolic pathways of plant vesicles in vivo is crucial for their safe use, and challenges remain to reduce the risk of systemic toxicity of vesicles, remove excess vesicles efficiently and rapidly, and stabilize the vesicular drug carrier system. 100 Just as single drugs in TCM formulas are ineffective, the therapeutic effect of nanoparticles loaded with single TCM actives is limited, and the combined use of vesicular particles with TCM actives may accelerate their interaction with each other applied in combination may accelerate their interactions and increase drug toxicity. Further studies should focus on the implantation of https://doi.org/10.2147/IJN.S463145…”

Section: Discussionmentioning

confidence: 99%

“…Future studies should focus on exploring the mechanisms of active targeting strategies to identify new targets and ligands that can enhance drug targeting and therapeutic effects. 100 Due to the synergistic effect of co-administration of different herbal components with a lower single dose and safer treatment, this is similar to the compound prescription of traditional Chinese medicine. Therefore, whether plant-derived nanovesicles can achieve the therapeutic effect of Chinese medicine prescription by loading different drugs or the combined action of multiple plant vesicles is awaiting further investigation.…”

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confidence: 99%

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Unlocking the Medicinal Potential of Plant-Derived Extracellular Vesicles: current Progress and Future Perspectives

Liu,

Lou,

Zhang

et al. 2024

IJN

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Botanical preparations for herbal medicine have received more and more attention from drug researchers, and the extraction of active ingredients and their successful clinical application have become an important direction of drug research in major pharmaceutical companies, but the complexity of extracts, multiple side effects, and significant individual differences have brought many difficulties to the clinical application of herbal preparations. It is noteworthy that extracellular vesicles as active biomolecules extracted from medicinal plants are believed to be useful for the treatment of a variety of diseases, including cancer, inflammation, regenerative-restorative and degenerative diseases, which may provide a new direction for the clinical utilization of herbal preparations. In this review, we sort out recent advances in medicinal plant extracellular vesicles and discuss their potential as disease therapeutics. Finally, future challenges and research directions for the clinical translation of medicinal plant extracellular vesicles are also discussed, and we expect that continued development based on medicinal plant extracellular vesicles will facilitate the clinical application of herbal preparations.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%