Potential role of coronary vasoconstriction in ischaemic heart disease: effect of exercise

Hess, Otto M.; Büchi, Martin; Kirkeeide, Richard L.; Niederer, Peter F.; Anliker, M.; Gould, K. Lance; Krayenbühl, H. P.

doi:10.1093/eurheartj/11.suppl_b.58

Cited by 26 publications

(4 citation statements)

References 5 publications

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“…However, dose titration is more difficult. Physical measures of endothelium-dependent responses include exercise, 13, 14 or pacing induced tachycardia as a surrogate for exercise, 15, 16 and induce an increase in coronary blood flow and thus shear stress on the coronary circulation, which leads to flow mediated endothelium-dependent vasomotion of the epicardial vessels. Similar responses can be seen in response to mental stress.…”

Section: Methods To Assess Vascular Functionmentioning

confidence: 99%

The Assessment of Endothelial Function

et al. 2012

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The discovery of the endothelium as a crucial organ for the regulation of the vasculature to physiological needs and the recognition of endothelial dysfunction as a key pathological condition - which is associated with most if not all cardiovascular risk factors - led to a tremendous boost of endothelial research in the past 3 decades. Despite the possibility to measure endothelial function in the individual and its widespread use in research, its use as a clinical tool in daily medicine is not established yet. We review the most common methods to assess vascular function in humans and discuss their advantages and disadvantages. Furthermore we give an overview about clinical settings were endothelial function measurements may be valuable in individual patients. Specifically, we provide information why endothelial function is not only a risk marker for cardiovascular risk but may also provides prognostic information beyond commonly used risk scores in primary prevention, and in patients with already established coronary disease. We conclude, that non-invasive endothelial function measurements provide valuable additional information, however, to ascertain its use for daily clinical practice, future research should determine whether endothelial function can be used to guide treatment in the individual and if this translates into better outcomes.

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Section: Methods To Assess Vascular Functionmentioning

confidence: 99%

The Assessment of Endothelial Function

et al. 2012

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“…for maintenance of oxygen supply) [51,52]. This reduces the amplitude of the flow reserve, so that if needed, flow reserve may not be sufficient for adequate supply of the end organ, which may in turn lead to symptoms such as angina pectoris in the heart [53,54]. Also, repeated microembolisms may alter downstream vascular resistance (reviewed in [45]).…”

Section: The Vascular Continuum: Interaction Between Micro- and Macromentioning

confidence: 99%

Metabolic memory: a vascular perspective

Jax

2010

Cardiovasc Diabetol

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“…However, differences in vasomotion between graft conduits and atherosclerotic coronary arteries could have some influence: patients with coronary artery disease show exercise-induced vasoconstriction of the stenotic segments [4], a phenomenon considered to reflect severe endothelial dysfunction at the site of atherosclerotic lesions. Vessel resistance is directly proportional to the length of the vessel and the viscosity of the blood, and inversely proportional to the fourth power of luminal diameter (Poiseuille's law).…”

Section: Introductionmentioning

confidence: 99%