Potential Role of Exercise in Retinal Health

Pardue, Machelle T.; Chrenek, Micah A; Schmidt, Robin H.; Nickerson, John M.; Boatright, Jeffrey H

doi:10.1016/bs.pmbts.2015.06.011

Cited by 9 publications

(6 citation statements)

References 78 publications

(93 reference statements)

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“…We have previously shown that environmental enrichment (EE)—an experimental paradigm in which laboratory animals are raised in the presence of increased social, sensorial, and motor stimulation—slows down photoreceptor degeneration and preserves vision in the rd10 mouse, a well-known RP model with a mutation in the rod-specific phosphodiesterase gene (5, 6). Analogous studies based on physical exercise alone (one of the components of EE) have shown positive effects on the same and other models of photoreceptor degeneration (7, 8), and the potential beneficial effects of exercise on the progression of human RP are being assessed through a specific pilot study ( https://clinicaltrials.gov/ identifier: NCT03381235).…”

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confidence: 99%

Rescuing cones and daylight vision in retinitis pigmentosa mice

et al. 2019

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Hallmark of retinitis pigmentosa (RP) is the primary, genetic degeneration of rods followed by secondary loss of cones, caused by still elusive biologic mechanisms. We previously shown that exposure of rd10 mutant mice, modeling autosomal recessive RP, to environmental enrichment (EE), with enhanced motor, sensorial and social stimuli, results into a sensible delay of retinal degeneration and vision loss. Searching for effectors of EE‐mediated retinal protection, we performed transcriptome analysis of the retina of rd10 enriched and control mice and found that gene expression at the peaks of rod and cone degeneration is characterized by a strong inflammatory/immune response, which is however measurably lower in enrichment conditions. Treating rd10 mice with dexamethasone during the period of maximum photoreceptors death lowered retinal inflammation and caused a preservation of cones and cone‐mediated vision. Our findings indicate a link between retinal inflammation and bystander cone degeneration, reinforcing the notion that cone vision in RP can be preserved using anti‐inflammatory approaches.—Guadagni, V., Biagioni, M., Novelli, E., Aretini, P., Mazzanti, C. M., Strettoi, E. Rescuing cones and daylight vision in retinitis pigmentosa mice. FASEB J. 33, 10177–10192 (2019). http://www.fasebj.org

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confidence: 99%

Rescuing cones and daylight vision in retinitis pigmentosa mice

et al. 2019

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“…Furthermore, recent evidence suggests a positive role of physical exercise on the retinal physiology. 21, 31 In this study, the lack of significant ocular structural differences between the two groups may be related to experimental factors. For example, although our subjects exercised six days per week, the duration of each training session may have not been long enough to effectively counteract the cephalad fluids shift induced by head-down-tilt and to reduce the amount of peripapillary retinal thickening post bed rest.…”

Section: Discussionmentioning

confidence: 79%

Ophthalmological Evaluation of Integrated Resistance and Aerobic Training During 70-Day Bed Rest

Taibbi

Cromwell

Zanello

et al. 2017

aerosp med hum perform

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INTRODUCTION We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-day 6° head-down-tilt (HDT) bed rest (BR). METHODS Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions. Mixed-effects linear models compared pre and post-HDTBR intraocular pressure (IOP), Spectralis OCT circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and peripapillary retinal thickness observations between groups. RESULTS Six controls and nine exercisers completed the study. There was an overall effect of BR on our outcomes. Except Goldmann IOP (mean pre/post difference in controls and exercisers: −0.47mmHg versus +1.14mmHg), the magnitude of changes from baseline was not significantly different between groups. There was a +1.38mmHg and a +1.63mmHg iCare IOP increase during BR in controls and exercisers, respectively. Spectralis OCT detected a +1.33μm average cpRNFLT increase in both groups, a +9.77μm and a +6.65μm peripapillary retinal thickening post-BR in controls and exercisers, respectively. Modified Amsler grid, red dot test, confrontational visual field, color vision, and stereoscopic fundus photography were unremarkable. CONCLUSIONS Seventy-day HDTBR induced peripapillary retinal thickening and cpRNFL thickening without visible signs of optic disc edema. The magnitude of such changes was not different between controls and exercisers. A slight IOP increase during BR subsided post-BR. Further study should evaluate whether different physical exercise paradigms may prevent/mitigate the risk of space-related visual impairment.

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“…Increased efforts are needed to provide reliable information about the potentially safe, nonregulated interventions that are widely claimed to slow retinal disease, including dietary antioxidants, 132 red light, 133 light-protection, 134 electrical stimulation, 135 anti-apoptotic approaches, 40,136 as well as the mounting evidence that physical exercise may provide a benefit in IRD. [137][138][139][140][141] Most critically, best practices are needed for educating patients and the public on the potential dangers of direct-to-consumer treatments shown to have significant risk of harm, such as autologous nonocular tissue-derived cell therapy. [142][143][144]…”

Section: Providing Guidancementioning

confidence: 99%

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

Thompson

Iannaccone

Ali

et al. 2020

Trans. Vis. Sci. Tech.

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Major advances in the study of inherited retinal diseases (IRDs) have placed efforts to develop treatments for these blinding conditions at the forefront of the emerging field of precision medicine. As a result, the growth of clinical trials for IRDs has increased rapidly over the past decade and is expected to further accelerate as more therapeutic possibilities emerge and qualified participants are identified. Although guided by established principles, these specialized trials, requiring analysis of novel outcome measures and endpoints in small patient populations, present multiple challenges relative to study design and ethical considerations. This position paper reviews recent accomplishments

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Potential Role of Exercise in Retinal Health

Cited by 9 publications

References 78 publications

Rescuing cones and daylight vision in retinitis pigmentosa mice

Rescuing cones and daylight vision in retinitis pigmentosa mice

Ophthalmological Evaluation of Integrated Resistance and Aerobic Training During 70-Day Bed Rest

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

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