Potential role of gut microbiota-LCA-INSR axis in high fat-diet-induced non-alcoholic fatty liver dysfunction: From perspective of radiation variation

Pan, Huiji; Zhou, Meiling; Zhao, Jiang; Luo, Juhua; Jin, Jing; Shen, Liangfang; Zhou, Pingkun; Huang, Ruixue

doi:10.1016/j.crfs.2022.09.022

Cited by 4 publications

(1 citation statement)

References 64 publications

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“…Furthermore, the IL-17 and VEGF signaling pathways may contribute to a decrease in HF ( Kumar et al, 2016 ; Fabre et al, 2018 ; Martínez-López et al, 2019 ; Qiao et al, 2020 ; Ghanim et al, 2021 ; He et al, 2022 ). Huiji Pan et al discovered that gut microbiota influence H-L + HFD-induced liver fibrosis through alteration of the hepatic IRS1/Akt/mTOR signaling pathway ( Pan et al, 2022 ). According to Jiang’s study ( Jiang et al, 2020 ), Lactobacillus may enhance the intestinal milieu and alleviate the condition, and the level of VEGF is also dramatically lowered with the reduction of liver cancer.…”

Section: Discussionmentioning

confidence: 99%

Exploration of the potential mechanism of Baicalin for hepatic fibrosis based on network pharmacology, gut microbiota, and experimental validation

et al. 2023

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Baicalin (BA) is among the most effective and abundant flavonoids extracted from Scutellaria baicalensis that may be utilized to treat diseases associated with hepatic fibrosis (HF). Through network pharmacology, gut microbiota, and experimental validation, this research intends to elucidate the multi-target mechanism of BA on HF. BA targets were screened using databases and literature. As a result, In the anti-HF mechanism, the BA and 191 HF-associated targets interact, with 9 specific targets indicating that the BA’s anti-HF mechanism is closely linked to gut microbiota. Consequently, rat intestinal content samples were obtained and examined using 16S rRNA sequencing. In the BA-treated group, the gut microbiota was positively regulated at the phylum,and genus levels, with Lactobacillus performing significantly. The study concluded that BA has a multi-targeted anti-HF effect and has changed the gut microbial ecosystem.

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