Potential role of high‐field MRI for studies in Parkinson's disease

Schuff, Norbert

doi:10.1002/mds.22647

Cited by 26 publications

(19 citation statements)

References 42 publications

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“…Especially DWI appears as a promising candidate since it may detect diffusion abnormalities in the basal ganglia and infratentorial structures in patients with APD even at early disease stages, and is furthermore widely available on whole body MR scanners and acquirable within few minutes. At higher magnetic fields of 3 T and more, several MRI methodologies, including structural MRI, imaging of brain iron, DTI, arterial spin labeling perfusion imaging, rotating frame imaging, and MRS, provide improved sensitivity and image contrasts to study brain alterations in PD [157] . Furthermore, recent fMRI studies have been used to detect preclinical reorganization of functional brain networks with additional recruitment of motor cortical areas in heterozygous Parkin and PINK1 gene mutation carriers [158] , which are at risk to develop PD.…”

Section: Resultsmentioning

confidence: 99%

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

et al. 2010

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The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology, even for movement disorder specialists. Despite published consensus operational criteria for the diagnosis of Parkinson’s disease (PD) and the various atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy, multiple system atrophy, and corticobasal syndrome, the clinical separation of APDs from PD carries a high rate of misdiagnosis. However, an early differentiation between APD and PD, each characterized by a largely different natural history, is crucial for determining the prognosis and choosing a treatment strategy. Despite limitations, the different modern magnetic resonance (MR) techniques have undoubtedly added to the differential diagnosis of neurodegenerative parkinsonism. Conventional MRI with visual assessment of T₂- and T₁-weighted imaging as well as various advanced MRI techniques offer objective measures and may therefore be useful tools in the diagnostic workup of PD and APDs. In clinical practice, conventional MRI is a well-established method for the exclusion of symptomatic parkinsonism due to other pathologies such as tumors, cerebral ischemia or inflammatory diseases. Furthermore, over the past two decades, advances in MR techniques have enabled to quantitatively illustrate abnormalities in the basal ganglia and infratentorial structures in APDs by methods such as magnetic resonance volumetry, diffusion-weighted imaging, magnetization transfer imaging and proton magnetic resonance spectroscopy. This article aims to review research findings on the value of MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders.

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Section: Resultsmentioning

confidence: 99%

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

et al. 2010

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“…Early on, Parkinson disease was declared one potential disease group with high benefit from 7 T imaging [42]. In Parkinson disease, SWI imaging at 7 T revealed an increase in susceptibility of the pars compacta compared with controls, which correlates with the predicted increase in brain iron.…”

Section: Vesselsmentioning

confidence: 79%

Perspectives of Ultra-High-Field MRI in Neuroradiology

2015

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“…Moreover, MRI studies measuring the width of the SN demonstrated loss of signal in a lateral to medial gradient in PD, correlating with conventional clinical measures of disease severity, but only in a small number of patients. Thus, these results show that morphological changes in PD exist, and, in particular, that the greater sensitivity and higher tissue contrast of MRI at higher magnetic fields may, compared with MRI at lower magnetic fields, lead to stronger and more robust findings of brain atrophy in PD (Schuff, 2006).…”

Section: Mri-based Volumetric Analysismentioning

confidence: 89%

Differences between conventional and non conventional MRI techniques in Parkinson�s disease

Baglieri¹,

Ma²,

Morabito³

et al. 2013

Fneur

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SummaryMagnetic resonance imaging (MRI) provides an in vivo assessment of cortical and subcortical regions affected in Parkinson's disease (PD). This review summarizes the most important conventional and non-conventional MRI techniques applied in this field. Standard neuroimaging techniques have played a marginal role in the diagnosis and follow-up of PD, essentially being used only to discriminate atypical syndromes from PD, to exclude secondary causes such as vascular lesions, and to confirm the absence of specific imaging features found in atypical parkinsonisms. However, non-conventional MRI techniques, i.e. new neuroimaging approaches such as magnetic resonance spectroscopy, diffusion tensor imaging, and functional MRI, may allow the detection of structural, functional and metabolic changes useful not only for differential diagnosis, but also for early diagnosis and outcome and treatment monitoring in PD. In addition, we illustrate the advantages of high-field MRI over lower magnetic fields, highlighting the great potential of advanced neuroimaging techniques.

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Potential role of high‐field MRI for studies in Parkinson's disease

Cited by 26 publications

References 42 publications

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

Perspectives of Ultra-High-Field MRI in Neuroradiology

Differences between conventional and non conventional MRI techniques in Parkinson�s disease

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