Potential role of <i>Limosilactobacillus fermentum </i>as a probiotic with anti-diabetic properties: A review

Lacerda, Diego Cabral; Costa, Pierre Mendes Da; Pontes, Paula Brielle; Santos, Lucas Alves Carneiro dos; Neto, José Patrocínio Ribeiro Cruz; Luis, Cristiane Cosmo Silva; Brito, Vanessa Polyana de Sousa; Alves, José Luiz

doi:10.4239/wjd.v13.i9.717

Cited by 24 publications

(11 citation statements)

References 54 publications

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“…Treatment with DHI-V A P 2000 @CD markedly reversed these changes (Figure E-b and Supplemental Figure S13). The genus Limosilactobacillus , known for its positive modulation of the host antioxidant and anti-inflammatory system, showed a drastic decline in the BDL group, but its concentration were restored with DHI@CD, DHI-P 2000 @CD and DHI-V A P 2000 @CD treatments . Similar variations were observed in the genus Lactobacillus .…”

Section: Resultssupporting

confidence: 57%

Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis

Niu,

Meng,

Cui

et al. 2023

ACS Nano

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Section: Resultssupporting

confidence: 57%

Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis

Niu,

Meng,

Cui

et al. 2023

ACS Nano

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“…Among of them, Blautia , as one of butyragenic genera, its level is correlated to circadian oscillation and has been reported being positively associated with sleep quality in young and healthy people ( Grosicki et al, 2020 ; Koh et al, 2021 ; Ozato et al, 2022 ). Furthermore, L. fermentum have been demonstrated its butyrate-producing activity and sleep-improving effect in vitro and in vivo ( Lin et al, 2019 ; Lacerda et al, 2022 ). L. fermentum -containing probiotic mixture can significantly improve the mood and sleep quality in clinical trial volunteers ( Marotta et al, 2019 ; Dos Reis Lucena et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Exopolysaccharide is the potential effector of Lactobacillus fermentum PS150, a hypnotic psychobiotic strain

Huang

Chu

Wu³

et al. 2023

Front. Microbiol.

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Psychobiotics are a class of probiotics that confer beneficial effects on the mental health of the host. We have previously reported hypnotic effects of a psychobiotic strain, Lactobacillus fermentum PS150 (PS150), which significantly shortens sleep latency in experimental mice, and effectively ameliorate sleep disturbances caused by either caffeine consumption or a novel environment. In the present study, we discovered a L. fermentum strain, GR1009, isolated from the same source of PS150, and found that GR1009 is phenotypically distinct but genetically similar to PS150. Compared with PS150, GR1009 have no significant hypnotic effects in the pentobarbital-induced sleep test in mice. In addition, we found that heat-killed PS150 exhibited hypnotic effects and altered the gut microbiota in a manner similar to live bacteria, suggesting that a heat-stable effector, such as exopolysaccharide (EPS), could be responsible for these effects. Our comparative genomics analysis also revealed distinct genetic characteristics in EPS biosynthesis between GR1009 and PS150. Furthermore, scanning electron microscopy imaging showed a sheet-like EPS structure in PS150, while GR1009 displayed no apparent EPS structure. Using the phenol-sulfate assay, we found that the sugar content value of the crude extract containing EPS (C-EPS) from PS150 was approximately five times higher than that of GR1009, indicating that GR1009 has a lower EPS production activity than PS150. Through the pentobarbital-induced sleep test, we confirmed the hypnotic effects of the C-EPS isolated from PS150, as evidenced by a significant reduction in sleep latency and recovery time following oral administration in mice. In summary, we utilized a comparative approach to delineate differences between PS150 and GR1009 and proposed that EPS may serve as a key factor that mediates the observed hypnotic effect.

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“…Transplantation of Lactobacillus can reduce inflammatory response. Lactobacillus and Parabacteroides were bacteria that can produce short-chain fatty acids (SCFAs) (43). SCFAs can enhance the autophagy of renal tubular cells and attenuate the renal fibrosis in diabetic mice (44).…”

Section: Discussionmentioning

confidence: 99%

Sacubitril/Valsartan contributes to improving the diabetic kidney disease and regulating the gut microbiota in mice

et al. 2022

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BackgroundDiabetic kidney disease (DKD), as a serious microvascular complication of diabetes, has limted treatment options. It is reported that the Sacubitril/Valsartan (Sac/Val) can improve kidney function, and the disordered gut microbiota and part of its metabolites are related to the development of DKD. Therefore, we aim to explore whether the effect of Sac/Val on DKD is associated with the gut microbiota and related plasma metabolic profiles.MethodsMale C57BL/6J mice were randomly divided into 3 groups: Con group (n = 5), DKD group (n = 6), and Sac/Val group (n = 6) . Sac/Val group was treated with Sac/Val solution. The intervention was given once every 2 days for 6 weeks. We measured the blood glucose and urine protein level of mice at different times. We then collected samples at the end of experiment for the 16s rRNA gene sequencing analysis and the untargeted plasma metabonomic analysis.ResultsWe found that the plasma creatinine concentration of DKD-group mice was significantly higher than that of Con-group mice, whereas it was reduced after the Sac/Val treatment. Compared with DKD mice, Sac/Val treatment could decrease the expression of indicators related to EndMT and renal fibrosis like vimentin, collagen IV and fibronectin in kidney. According to the criteria of LDA ≥ 2.5 and p<0.05, LefSe analysis of gut microbiota identified 13 biomarkers in Con group, and 33 biomarkers in DKD group, mainly including Prevotella, Escherichia_Shigella and Christensenellaceae_R_7_group, etc. For the Sac/Val group, there were 21 biomarkers, such as Bacteroides, Rikenellaceae_RC9_gut_group, Parabacteroides, Lactobacillus, etc. Plasma metabolomics analysis identified a total of 648 metabolites, and 167 important differential metabolites were screened among groups. KEGG pathway of tryptophan metabolism: M and bile secretion: OS had the highest significance of enrichment.ConclusionsSac/Val improves the renal function of DKD mice by inhibiting renal fibrosis. This drug can also regulate gut microbiota in DKD mice.

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Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review

Cited by 24 publications

References 54 publications

Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis

Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis

Exopolysaccharide is the potential effector of Lactobacillus fermentum PS150, a hypnotic psychobiotic strain

Sacubitril/Valsartan contributes to improving the diabetic kidney disease and regulating the gut microbiota in mice

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