Potential Role of Labisia pumila in the Prevention and Treatment of Chronic Diseases

Hussain, Nik Hazlina Nik; Kadir, Azidah Abdul

doi:10.5539/jfr.v2n4p55

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…Petri plates and pipette were washed with distilled water and dried. Petri plates were then placed in an oven (Memmert, Germany) at 180 0 C for 2 hr [7].…”

Section: Sterilizationmentioning

confidence: 99%

Shelf life quality of Labisia pumila extract and effect of granulation on dissolution rate

Khamis¹

2019

JESR

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Lyophilized from plants extract is a process to prolong the amounts of phytochemicals in a solid form. The bioactive compound in LP, which is Gallic acid should be stable and bioavailable during the downstream processing such as drying process in order to achieve its optimum health benefits. Therefore, this study focuses on the impact of lyophilize methods such as spray drying followed by granulator method in order to determine the stability of bioactive compound in LP during drying and storage. After the powdered produce, it will test on the model of human digestion (dissolution study) either the amounts of phytochemicals still remain stable. Finally, shelf-life quality analysis and the dissolution rate (capsule size 0 and 1) were carried out. The results obtained show the methods employed in this study can be used for analysis of quality content and dissolution tests of LP capsules. For LB in shelf-life quality study, parameters for appearance and TYMC showed no significant difference after 3 months. For pH, the slight decrease in pH level will increase the number of TAMC in powder form. Compared to granule form, the pH level more consistent and the number of TAMC also in a control condition. The dissolution of capsules containing powder and granulated of LP showed a high percentage of bioactive compound released into the dissolution medium, although the bioactive compound content of herbal products (capsule size 1) was found to be half that of capsules size 0. Through observation for both capsules size content of LP, the maximum dissolution was achieved after 100 min.

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“…Petri plates and pipette were washed with distilled water and dried. Petri plates were then placed in an oven (Memmert, Germany) at 180 0 C for 2 hr [7].…”

Section: Sterilizationmentioning

confidence: 99%

Shelf life quality of Labisia pumila extract and effect of granulation on dissolution rate

Khamis¹

2019

JESR

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“…some studied indicated that L. pumila has possible application (Table 6) as anti-inflammatory activity, cytotoxic agent, immunomodulatory, antioxidant, lypolytic and aphrodisiac affects (George et al, 2014;Karimi et al, 2013a). Natural bioactive compound such as resorcinols, flavonoids, saponins and phenolic acid are found in the L. pumila (Karimi and Jaafar, 2011;Hussain and Kadir, 2013). Other studied has indicated that isoflavonoids, benzoquinones, alkenyl resoronol, triterpenoids as one of the bioactive compound in L. pumila (George et al, 2014).…”

Section: Gyanura Procumbens: Gynura Procumbensmentioning

confidence: 99%

Bioactive Compound and Therapeutic Value of the Some Malaysia Medicinal Plants: A Review

Muhamm¹,

Khandaker²,

Mat³

2015

J. of Agronomy

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There are many medicinal plants that have been used since folk ages. These plants have been recognized to have pharmaceutical properties and beneficial impact on health. This study discusses the use of ten medicinal plants in the traditional medicinal system of Malaysia and related scientific on their antioxidant activity, which demonstrate their pharmaceutical properties. The plants viewed are Andrographis paniculata, Cosmos caudatus, Eurycoma longifolia, Ficus deltoidea, Gynura procumbens, Labisia pumila, Orthosiphon stamineus, Phyllanthus niruri, Piper betle and Uncaria gambir. All the plants mentioned in this study have therapeutic properties such as antioxidation, antidiabetics, antiinflammation, which explains and validates their uses in traditional and modern medicine.

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“…The HMPs from L. pumila reportedly benefit consumers in terms of general health maintenance, and they have been used for inner health treatment, easing childbirth, and estrogen replacement therapy for women, as well as other potential treatments for chronic diseases [7][8][9][10][11][12][13] According to the Malaysia National Pharmaceutical Regulatory Agency (2020), most registered Labisia HMPs on the Malaysian market are in the form of capsules (84%), teabags (4%), tablets (3%), emulsions (1%), and bolus (1%), among others. Labisia pumila (family Myrsinaceace) commonly known as Kacip Fatimah (KF) is one of the most famous herbal plants which has a variety of local names [4].…”

Section: Introductionmentioning

confidence: 99%

Integrated Approach for Species Identification and Quality Analysis for Labisia pumila Using DNA Barcoding and HPLC

Tarmizi

Wagiran

Salleh

et al. 2021

Plants

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Labisia pumila is a precious herb in Southeast Asia that is traditionally used as a health supplement and has been extensively commercialized due to its claimed therapeutic properties in boosting a healthy female reproductive system. Indigenous people used these plants by boiling the leaves; however, in recent years it has been marketed as powdered or capsuled products. Accordingly, accuracy in determination of the authenticity of these modern herbal products has faced great challenges. Lack of authenticity is a public health risk because incorrectly used herbal species can cause adverse effects. Hence, any measures that may aid product authentication would be beneficial. Given the widespread use of Labisia herbal products, the current study focuses on authenticity testing via an integral approach of DNA barcoding and qualitative analysis using HPLC. This study successfully generated DNA reference barcodes (ITS2 and rbcL) for L.pumila var. alata and pumila. The DNA barcode that was generated was then used to identify species of Labisia pumila in herbal medicinal products, while HPLC was utilized to determine their quality. The findings through the synergistic approach (DNA barcode and HPLC) implemented in this study indicate the importance of both methods in providing the strong evidence required for the identification of true species and to examine the authenticity of such herbal medicinal products.

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Potential Role of Labisia pumila in the Prevention and Treatment of Chronic Diseases

Cited by 10 publications

References 22 publications

Shelf life quality of Labisia pumila extract and effect of granulation on dissolution rate

Shelf life quality of Labisia pumila extract and effect of granulation on dissolution rate

Bioactive Compound and Therapeutic Value of the Some Malaysia Medicinal Plants: A Review

Integrated Approach for Species Identification and Quality Analysis for Labisia pumila Using DNA Barcoding and HPLC

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