Potential role of lysine succinylation in the response of moths to artificial light at night stress

Huang, Zhilian; He, Li; Sang, Wen; Wang, Lijun; Huang, Qiuying; Lei, Chaoliang

doi:10.1016/j.ecoenv.2021.112334

Cited by 10 publications

(5 citation statements)

References 82 publications

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“…ALAN suppressed the accumulation of both water-soluble carbohydrates and glycogen in LD mosquitoes ( Figure 2 D,E, Supplementary Figure S1D,E ). In other insects, ALAN has been found to influence metabolism and feeding [ 51 , 89 , 90 , 91 ]. Low carbohydrate and glycogen levels in ALAN-exposed mosquitoes may therefore suggest that light pollution disrupts the ability of LD-reared mosquitoes to acquire carbohydrates.…”

Section: Discussionmentioning

confidence: 99%

Light Pollution Disrupts Seasonal Differences in the Daily Activity and Metabolic Profiles of the Northern House Mosquito, Culex pipiens

Wolkoff

Fyie

Meuti

2023

Insects

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The Northern House mosquito, Culex pipiens, is an important disease vector, and females are capable of surviving the winter in a state of overwintering diapause. This species’ diapause response has been extensively studied, and recent evidence suggests that the circadian clock is involved in measuring seasonal changes in daylength to initiate the diapause response. However, differences in the circadian activity of diapausing and non-diapausing Cx. pipiens have not been thoroughly investigated. Additionally, recent findings indicate that artificial light at night (ALAN) can disrupt mosquito diapause, potentially prolonging the mosquito biting season. We compared the circadian locomotor activity of mosquitoes reared in diapause-averting, long-day conditions and diapause-inducing, short-day conditions with and without ALAN to elucidate the interplay between circadian activity, diapause, and light pollution. We also uncovered metabolic differences between mosquitoes reared under diapausing and non-diapausing photoperiods with and without ALAN by measuring the concentration of protein, fructose, glycogen, water-soluble carbohydrates, and lipids. We found that ALAN exposure altered several diapause-associated phenotypes including slightly, but not significantly, increasing activity levels in short day-reared mosquitoes; and preventing some short day-reared mosquitoes from accumulating lipids. ALAN also significantly reduced glycogen and water-soluble carbohydrate levels in long day-reared mosquitoes. Based on our findings, light pollution may decrease insect fitness by perturbing metabolism, and may also impact several phenotypes associated with insect diapause, potentially extending the mosquito biting season and preventing insects in urban environments from overwintering successfully.

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Section: Discussionmentioning

confidence: 99%

Light Pollution Disrupts Seasonal Differences in the Daily Activity and Metabolic Profiles of the Northern House Mosquito, Culex pipiens

Wolkoff

Fyie

Meuti

2023

Insects

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“…Lysine succinylation (Ksucc) is a new, broad-spectrum, dynamic, reversible PTM that has been discovered in recent years (Figure 1) . It is involved in almost all biological processes of organisms (Ye and Li, 2022), playing an important role in the metabolic regulation, signal transduction and cell differentiations (Amirkashani et al, 2023;Huang et al, 2023), mainly through the regulation of protease activity and gene expression (Huang et al, 2021). The regulation of succinylation and involves multiple factors, including succinyl-donor and the regulators of succinylation (Lu and Han, 2022).…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of protein succinylation and disease development

Hou,

Zhu,

et al. 2024

Front. Mol. Biosci.

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As a novel post-translational modification of proteins, succinylation is widely present in both prokaryotes and eukaryotes. By regulating protein translocation and activity, particularly involved in regulation of gene expression, succinylation actively participates in diverse biological processes such as cell proliferation, differentiation and metabolism. Dysregulation of succinylation is closely related to many diseases. Consequently, it has increasingly attracted attention from basic and clinical researchers. For a thorough understanding of succinylation dysregulation and its implications for disease development, such as inflammation, tumors, cardiovascular and neurological diseases, this paper provides a comprehensive review of the research progress on abnormal succinylation. This understanding of association of dysregulation of succinylation with pathological processes will provide valuable directions for disease prevention/treatment strategies as well as drug development.

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“…In recent years, post-translational modifications of protein, such as propionylation, glutarylation, acetylation and succinylation, have become the focus of research (2,3). Succinylation has emerged as a key regulator of metabolic pathways in various organisms (1,(3)(4)(5). This modification involves the transfer of a succinyl group (-CO-CH2-CH2-CO-) from succinyl-CoA to the ε-amino group of lysine residues in target proteins (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Protein succinylation: regulating metabolism and beyond

Hou,

Chen,

et al. 2024

Front. Nutr.

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Modifications of protein post-translation are critical modulatory processes, which alters target protein biological activity，function and/or location, even involved in pathogenesis of some diseases. So far, there are at least 16 types of post-translation modifications identified, particularly through recent mass spectrometry analysis. Among them, succinylation (Ksuc) on protein lysine residues causes a variety of biological changes. Succinylation of proteins contributes to many cellular processes such as proliferation, growth, differentiation, metabolism and even tumorigenesis. Mechanically, Succinylation leads to conformation alteration of chromatin or remodeling. As a result, transcription/expression of target genes is changed accordingly. Recent research indicated that succinylation mainly contributes to metabolism modulations, from gene expression of metabolic enzymes to their activity modulation. In this review, we will conclude roles of succinylation in metabolic regulation of glucose, fat, amino acids and related metabolic disease launched by aberrant succinylation. Our goal is to stimulate extra attention to these still not well researched perhaps important succinylation modification on proteins and cell processes.

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Potential role of lysine succinylation in the response of moths to artificial light at night stress

Cited by 10 publications

References 82 publications

Light Pollution Disrupts Seasonal Differences in the Daily Activity and Metabolic Profiles of the Northern House Mosquito, Culex pipiens

Light Pollution Disrupts Seasonal Differences in the Daily Activity and Metabolic Profiles of the Northern House Mosquito, Culex pipiens

Dysregulation of protein succinylation and disease development

Protein succinylation: regulating metabolism and beyond

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