Potential Role of Macrophages in Experimental Keratomycosis

Hu, Jianzhang; Wang, Ye; Xie, Lixin

doi:10.1167/iovs.07-1237

Cited by 40 publications

(33 citation statements)

References 41 publications

(35 reference statements)

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“…In line with the previous observation that TLR4 is expressed on intracorneally infiltrating macrophages during fungal keratitis, 28 we observed that a substantial proportion of F4/80-positive macrophages expressed TLR4 in injured cornea on day 2 postinjury (Supplemental Figure IIA). HMGB1 protein was detected in macrophages at the same time (Supplemental Figure IIA).…”

Section: Tlr4-positive Macrophages and Endothelial Cells Express Hmgb1supporting

confidence: 92%

“…[31][32][33][34][35] Given the fact that TLR4 is expressed on macrophages to mediate inflammatory responses, 28 we examined ϩ macrophages started to accumulate on day 1 and reached a peak on day 4 after injury ( Figure 2A and 2B). Although the kinetics of macrophage infiltration in the wounds were similar in control and TLR4 Ϫ/Ϫ animals ( Figure 2B), the infiltration of macrophages in TLR4 Ϫ/Ϫ wounded corneas was significantly attenuated ( Figure 2B).…”

Section: Tlr4 Is Required For the Recruitment Of Macrophages In Cnvmentioning

confidence: 99%

“…Because TLR4-mediated signaling can enhance the functions of macrophages, 28 we next examined the effects of exogenous HMGB1 on angiogenic factor expression by primary peritoneal murine macrophage. HMGB1 markedly increased the Figure 5A).…”

Section: Hmgb1-induced Angiogenic Factor Expression By Murine Peritonmentioning

confidence: 99%

“…27 Animal model studies indicate that development of inflammation and injurious responses in cornea depends on TLR4 signaling. 28,29 Because inflammation is a key process linked to angiogenesis, 2 in this study, we investigated the role of HMGB1-TLR4 signaling in angiogenesis using a model of CNV in mice. We found that TLR4 but not TLR2 was involved in the development of CNV.…”

mentioning

confidence: 99%

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High-Mobility Group Box-1 Mediates Toll-Like Receptor 4–Dependent Angiogenesis

Lin

Yang

Fang

et al. 2011

ATVB

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Objective-Inflammation is closely linked to angiogenesis, and Toll-like receptors (TLRs) are the key mediators of inflammatory responses. However, the impact of TLRs on angiogenesis is incompletely understood. In this study, we determined the involvement of TLRs in angiogenesis. Methods and Results-In a mouse model of alkali-induced corneal neovascularization (CNV), we found that CNV was attenuated in TLR4 Ϫ/Ϫ but not TLR2 Ϫ/Ϫ mice. Further study revealed that the absence of TLR4 led to decreased production of proangiogenic factors in association with reduced accumulation of macrophages at the site of wounds, which was associated with reduced expression of high-mobility group box-1 (HMGB1) protein, an endogenous ligand for TLR4. Topical application of HMGB1 to the injured cornea promoted CNV with increased macrophage accumulation in wild-type mice but not in TLR4 Ϫ/Ϫ mice. HMGB1 treatment in vitro also promoted the production of proangiogenic factors by mouse macrophages in a TLR4-dependent manner. Furthermore, antagonists of HMGB1 and TLR4 reduced CNV and macrophage recruitment in the injured cornea of wild-type mice. Conclusion-Our

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Section: Tlr4-positive Macrophages and Endothelial Cells Express Hmgb1supporting

confidence: 92%

Section: Tlr4 Is Required For the Recruitment Of Macrophages In Cnvmentioning

confidence: 99%

Section: Hmgb1-induced Angiogenic Factor Expression By Murine Peritonmentioning

confidence: 99%

mentioning

confidence: 99%

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High-Mobility Group Box-1 Mediates Toll-Like Receptor 4–Dependent Angiogenesis

Lin

Yang

Fang

et al. 2011

ATVB

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“…(Hu et al, 2009) In vitro studies have shown that inactivated hyphae of Fusarium solani upregulate gene expression of TLRs-2, 3, 4 and 6, along with protein expression of TLRs 2 and 4 with resultant increases in cytokine expression of IL-6 and IL-8. The importance of TLR-4 in modulating the host defense mechanisms to fungi, especially Fusarium keratitis, has been demonstrated by several groups.…”

Section: Fungal Keratitismentioning

confidence: 99%

Trafficking of Immune Cells in the Cornea and Ocular Surface

Qazi¹,

Turhan²,

Hamrah³

2012

Advances in Ophthalmology

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Optical Coherence Tomography Image Analysis

Rabbani

Kafieh

Amini

2016

Wiley Encyclopedia of Electrical and Electronics Engineering

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This article presents the fundamentals of optical coherence tomography (OCT) for ophthalmologic applications along with a comparison with other eye imaging techniques. A classification of image modeling methods is provided to elaborate the possible models for representing OCT datasets. Ophthalmologic OCTs are then classified into two main subcategories, corneal and retinal images, and an overview of available preprocessing (including motion artifact correction, despeckling, and registration) and automatic segmentation of retinal OCTs is presented. The last part of the article discusses OCT classification and explores the means for automatic diagnosis of eye diseases. Herein, one section focuses on imaging biomarkers as features for categorization of ocular disease. The article concludes with an overview of current research on classification of OCT images based on ocular diseases.

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Potential Role of Macrophages in Experimental Keratomycosis

Abstract: Local depletion of macrophages may downregulate the immune response and aggravate fungal keratitis. Macrophages appear to play an important role in host defense against corneal infection of F. solani and C. albicans.

Cited by 40 publications

References 41 publications

High-Mobility Group Box-1 Mediates Toll-Like Receptor 4–Dependent Angiogenesis

High-Mobility Group Box-1 Mediates Toll-Like Receptor 4–Dependent Angiogenesis

Trafficking of Immune Cells in the Cornea and Ocular Surface

Optical Coherence Tomography Image Analysis

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