Potential role of medicinal plants for anti-atherosclerosis activity

Qadir, Muhammad Imran; Manzoor, Ayesha; Akash, Muhammad Sajid Hamid

doi:10.3329/bjp.v13i1.33478

Cited by 15 publications

(7 citation statements)

References 38 publications

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“…us, drugs including medicinal plants with hypolipidemic/antihyperlipidemic activities could equally be considered antiatherosclerotic and cardioprotective [108][109][110]. us, the hypolipidemic/antihyperlipidemic activity of CVE observed in this study is in tandem with those previously reported for Clerodendrum volubile and related species [32,80,[111][112][113][114].…”

Section: Discussionsupporting

confidence: 85%

“…It is equally well documented in the literature that a direct relationship exists between hypercholesterolemia and hyperlipidemia and atherosclerosis which is considered as a major cause of cardiovascular disease, especially coronary heart disease [ 105 – 107 ]. Thus, drugs including medicinal plants with hypolipidemic/antihyperlipidemic activities could equally be considered antiatherosclerotic and cardioprotective [ 108 – 110 ]. Thus, the hypolipidemic/antihyperlipidemic activity of CVE observed in this study is in tandem with those previously reported for Clerodendrum volubile and related species [ 32 , 80 , 111 – 114 ].…”

Section: Discussionmentioning

confidence: 99%

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Clerodendrum volubileEthanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats

Olorundare

Adeneye

Akinsola

et al. 2020

Journal of Toxicology

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Doxorubicin is widely applied in hematological and solid tumor treatment but limited by its off-target cardiotoxicity. Thus, cardioprotective potential and mechanism(s) of CVE in DOX-induced cardiotoxicity were investigated using cardiac and oxidative stress markers and histopathological endpoints. 50–400 mg/kg/day CVE in 5% DMSO in distilled water were investigated in Wistar rats intraperitoneally injected with 2.5 mg/kg DOX on alternate days for 14 days, using serum troponin I and LDH, complete lipid profile, cardiac tissue oxidative stress marker assays, and histopathological examination of DOX-treated cardiac tissue. Preliminary qualitative and quantitative assays of CVE’s secondary metabolites were also conducted. Phytochemical analyses revealed the presence of flavonoids (34.79 ± 0.37 mg/100 mg dry extract), alkaloids (36.73 ± 0.27 mg/100 mg dry extract), reducing sugars (07.78 ± 0.09 mg/100 mg dry extract), and cardiac glycosides (24.55 ± 0.12 mg/100 mg dry extract). 50–400 mg/kg/day CVE significantly attenuated increases in the serum LDH and troponin I levels. Similarly, the CVE dose unrelatedly decreased serum TG and VLDL-c levels without significant alterations in the serum TC, HDL-c, and LDL-c levels. Also, CVE profoundly attenuated alterations in the cardiac tissue oxidative stress markers’ activities while improving DOX-associated cardiac histological lesions that were possibly mediated via free radical scavenging and/or antioxidant mechanisms. Overall, CVE may play a significant therapeutic role in the management of DOX-induced cardiotoxicity in humans.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Clerodendrum volubileEthanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats

Olorundare

Adeneye

Akinsola

et al. 2020

Journal of Toxicology

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“…Investigators have also reported the protective effect of T. portulacastrum in adriamycin-induced nephrotic syndrome (Karim 2012). Qadir et al (2018) reported the potential role of medicinal plants as anti-atherosclerotic agents. Gong et al (2018) reported that GPR124 increases the pathogenesis of atherosclerosis via activation of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Protective and therapeutic effects of Trianthema portulacastrum against atherosclerosis in male albino rats via G-protein-coupled receptor 124

Gao

Cao

et al. 2019

AMB Expr

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Atherosclerosis is a severe cardiovascular disease characterized by narrowing of the lumen, plaque formation, and blood flow turbulence as a result of cholesterol and lipid accumulation in the inner lining of arteries. Bishkhapra (Trianthema portulacastrum Linn.) is a well-known common weed belonging to the family Aizoaceae. Several bioactive compounds have been isolated from this weed and widely used against several diseases. The present study evaluated the protective and therapeutic efficacies of T. portulacastrum against atherosclerosis in a rat model. The animals were divided into the sham, control (diabetes- + atherosclerosis-inducing diet), 100 mg/kg T. portulacastrum treatment, 200 mg/kg T. portulacastrum treatment, and positive control groups. Blood glucose, cholesterol, triglyceride, and other lipid parameters, as well as the expression of G-protein-coupled receptor 124 (GPR124), were measured. Glucose, cholesterol, and triglycerides were significantly reduced to near normal levels. The serum levels of fibrinogen, sVCAM-1, and oxidized low density lipoproteins were substantially increased in control rats. Treatment with the T. portulacastrum extract reversed these levels to near normal levels. The mRNA expression of GPR124 was increased by 150% in the control group. However, treatment with T. portulacastrum extract decreased the mRNA expression up to 40% compared with the control group. Rats treated with 100 and 200 mg/kg T. portulacastrum extract showed a decrease in GPR124 protein expression by 9.5% and 33.3%, respectively. Taken together, the results suggest that an extract of T. portulacastrum is effective against atherosclerosis in streptozotocin-induced diabetic rats.

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“…Plant extracts are reported to have medicinal effects such as antioxidant (Attanayake et al 2016), antibacterial (Ogbole et al 2018), antifungal (Giordani et al 2020), and anticancer (Sammar et al 2019). It also has been used as therapeutic drugs for degenerative diseases such as diabetes (Deo et al 2016) and cardiovascular (Qadir et al 2018). Advanced research in the pharmaceutical industry shifts people's perspectives on medicinal plants from unregulated traditional usage to phytopharmaceutical which is qualitatively and quantitatively standardized (Bhatt 2016).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Ten Extractives from Toba, North Sumatra and Mt. Merapi National Park Regions, Indonesia

Ismayati

Zulfiana

Himmi

et al. 2021

JSL

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Investigating beneficial chemical compounds of plant extracts is one of the ways to prevent biodiversity loss. This study evaluated the antimicrobial activity of indigenous plant extracts from Toba, North Sumatra, and Mt. Merapi National Park regions against Escherichia coli, Bacillus subtilis, Salmonella typhi, Staphylococcus aureus, Candida albicans, and Candida tropicalis by calculating the zone of microbial growth inhibition. Among the plant extracts, T5 that identified asToona sinensisshowed the highestmicrobial inhibitionto the growth of C. albicans, B. subtilis, S. typhi, and E. coli with the diameter growth of approximately 2.00, 1.80, 1.33, and 1.33 cm, respectively. Based on those results, T. sinensis was thensubsequently fractionated using n-hexane, ethyl acetate, and methanol, respectively.The resulted fractions also were evaluated for antimicrobial bioassay. All fractions have shown activity in inhibiting the growth of the microbes at 1% concentration. However, each fraction showedgrowth inhibition against certain microbes. The n-hexane fraction showed the greatest inhibitory activity for E. coli and S. typhi; ethyl acetate fraction for B. subtilis and C. albicans; and methanol fraction for E. coli and S. typhi. The results revealed that T. sinensis plant extract has great potential asan antimicrobial agent. Further investigation is needed to observe the mode of antimicrobial action of fractionated crude extracts of T. Sinensis. The exploring potency of Indonesian biodiversity opened up a new way for the utilization of plants for economic development and conservation.Keywords: antimicrobial plants, indigenous knowledge, Toba-North Sumatra, Mt. Merapi

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Potential role of medicinal plants for anti-atherosclerosis activity

Cited by 15 publications

References 38 publications

Clerodendrum volubileEthanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats

Clerodendrum volubileEthanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats

Protective and therapeutic effects of Trianthema portulacastrum against atherosclerosis in male albino rats via G-protein-coupled receptor 124

Antimicrobial Activity of Ten Extractives from Toba, North Sumatra and Mt. Merapi National Park Regions, Indonesia

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