Potential role of mitochondrial permeability transition pore following long-time hypothermic heart preservation

Rajesh, Katare Gopalrao; Sasaguri, Shiro; Tian, Zhuqing; Asakai, Rei

doi:10.1016/s0041-1345(02)03459-0

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…We have demonstrated the direct relation between the loss of myocardial ATP and apoptotic cell death [13,33]. The IP group in our study has prevented the apoptotic cell death, which was consistent with the wellmaintained ATP in the IP group.…”

Section: Discussionsupporting

confidence: 88%

Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels

Katare

Sasaguri

Suzuki

et al. 2004

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 88%

Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels

Katare

Sasaguri

Suzuki

et al. 2004

International Journal of Cardiology

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“…Heart transplantation has been accepted as the most effective treatment for end-stage heart disease, but preservation period for donor heart is limited to 4 to 6 h [1]. To extend the preservation periods and maximize the post-ischemic recovery, many attempts have been made in the past decades [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Supplementation of Nucleoside-Nucleotide Mixture Enhances Functional Recovery and Energy Metabolism Following Long-Time Hypothermic Heart Preservation

Xing¹,

Katare²,

Suzuki³

et al. 2005

Journal of Surgical Research

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Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence

Anselmi

2004

European Journal of Cardio-Thoracic Surgery

189

108

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Cardiac surgery (CS), in particular cardiopulmonary bypass and cardioplegia, have been reported to trigger myocardial inflammation and apoptosis. This surgery-related inflammatory reaction appears to be of extreme complexity with regard to its molecular, cellular and tissue mechanisms. Both experimental and clinical studies have ascertained the role of several hormonal mediators, mitochondria, cardioplegia and extracorporeal circulation temperature, apoptosis and even genetic modulators of damage. However, the correlations between these factors in vivo and post-surgery outcome and prognosis have not yet been systematically investigated. In animal models of myocardial cardioplegia and/or ischemia-reperfusion, experimental drugs such as antioxidants have been documented to provide amelioration of post-intervention cardiac performance and reduction of apoptosis suggesting the possibility of new therapeutic strategies. However, these findings have been only partially confirmed in humans. Moreover, markers for the differential detection of early and late phases of apoptosis are subjects of intense investigations. This review will provide an overview of the major studies about the link between ischemia, myocardial inflammation and apoptosis during and after CS, with particular regard to the markers and methods for apoptosis detection.

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Potential role of mitochondrial permeability transition pore following long-time hypothermic heart preservation

Cited by 7 publications

References 8 publications

Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels

Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels

Supplementation of Nucleoside-Nucleotide Mixture Enhances Functional Recovery and Energy Metabolism Following Long-Time Hypothermic Heart Preservation

Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence

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