Potential role of mitochondrial ROS in Sestrin2 degradation

The aim of this work was to evaluate the synthesis and structure-activity relationship of 4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl 2-phenylacetate derivatives as potential wound-healing agents. The IC values of the lead compounds ranged from 0.01 to 0.05 µM. These compounds also increased the levels of extracellular prostaglandin E (PGE) in A549 cells. Among the synthesized compounds, compounds 66, 67, 69, and 86 increased PGE levels 3- to 4-fold of those achieved with the negative control. Introduction of a halogen at the intermediate phenyl ring, compounds 66, 67, 69, and 86 resulted in higher IC values, which indicated lower cytotoxicity than that observed upon the introduction of other substituents at the same position. In particular, cells exposed to compound 69 showed significantly improved wound healing, and the wound closure rate achieved was approximately 3.2-fold higher than that of the control. Therefore, compound 69 can be used for tissue regeneration and treatment of diverse diseases caused by PGE deficiency. Overall, our findings suggested that compound 69 might be a novel candidate for skin wound therapy.

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Effect of thiazolidinedione phenylacetate derivatives on wound-healing activity

Park

Choi²,

Cho

2018

Arch. Pharm. Res.

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Quantitatively monitoring oxygen variation in endoplasmic reticulum with a fluorophore–phosphor energy transfer cassette

Bian

Song

et al. 2018

J. Mater. Chem. B

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Potential role of mitochondrial ROS in Sestrin2 degradation

Cited by 2 publications

References 28 publications

Effect of thiazolidinedione phenylacetate derivatives on wound-healing activity

Effect of thiazolidinedione phenylacetate derivatives on wound-healing activity

Quantitatively monitoring oxygen variation in endoplasmic reticulum with a fluorophore–phosphor energy transfer cassette

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