Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation

Nedachi, Taku; Conti, Marco

doi:10.1242/dev.01368

Cited by 14 publications

(11 citation statements)

References 41 publications

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“…The influence of protein tyrosine phosphatase PTPL1 in cell cycle and proliferation has not been extensively studied. Available data point towards a role in cytokinesis in HeLa cells [8] and in meiosis in Xenopus oocytes [9]. We have shown here that downregulation of endogenous PTPL1 by siRNA induces changes in cell cycle profile.…”

Section: Discussionsupporting

confidence: 53%

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Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells

Castilla

Flores

Conde

et al. 2012

Clin Exp Metastasis

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PTPL1, a non-receptor type protein tyrosine phosphatase, has been involved in the regulation of apoptosis and invasiveness of various tumour cell types, but its role in prostate cancer remained to be investigated. We report here that downregulation of PTPL1 by small interfering RNA in PC3 cells decreases cell proliferation and concomitantly reduces the expression of cell cycle-related proteins such as cyclins E and B1, PCNA, PTTG1 and phospho-histone H3. PTPL1 downregulation also increases the invasion ability of PC3 cells through Matrigel coated membranes. cDNA array of PTPL1-silenced PC3 cells versus control cells showed an upregulation of invasion-related genes such as uPA, uPAR, tPA, PAI-1, integrin α6 and osteopontin. This increased expression was also confirmed in PTPL1-silenced DU145 prostate cancer cells by quantitative real time PCR and western blot. These findings suggest that PTPL1 is an important mediator of central cellular processes such as proliferation and invasion.

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Section: Discussionsupporting

confidence: 53%

“…Moreover, PTPL1 overexpression induces defects in cytokinesis. Also, it has been shown that PTPL1 functions downstream of cAMP signaling and plays an essential role in controlling meiotic resumption in Xenopus oocytes [9]. In relation to invasion, there are several reports addressing a role of PTPL1 in this process.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells

Castilla

Flores

Conde

et al. 2012

Clin Exp Metastasis

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“…Noticeably, several genes from this group are directly involved in cell differentiation. PTPN13 is a proapoptotic protein tyrosine phosphatase, which is overexpressed in most cancer cells, and is involved in the regulation of cell differentiation (49). The expression pattern of CCNB1 is markedly different among differentiated lung cancers (11).…”

Section: Resultsmentioning

confidence: 99%

Constructing Molecular Classifiers for the Accurate Prognosis of Lung Adenocarcinoma

Guo¹,

Ward

et al. 2006

Clinical Cancer Research

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Purpose: Individualized therapy of lung adenocarcinoma depends on the accurate classification of patients into subgroups of poor and good prognosis, which reflects a different probability of disease recurrence and survival following therapy. However, it is currently impossible to reliably identify specific high-risk patients. Here, we propose a computational model system which accurately predicts the clinical outcome of individual patients based on their gene expression profiles. Experimental Design: Gene signatures were selected using feature selection algorithms random forests, correlation-based feature selection, and gain ratio attribute selection. Prediction models were built using random committee and Bayesian belief networks. The prognostic power of the survival predictors was also evaluated using hierarchical cluster analysis and Kaplan-Meier analysis.Results: The predictive accuracy of an identified 37-gene survival signature is 0.96 as measured by the area under the time-dependent receiver operating curves. The cluster analysis, using the 37-gene signature, aggregates the patient samples into three groups with distinct prognoses (Kaplan-Meier analysis, P < 0.0005, log-rank test). All patients in cluster 1 were in stage I, with N 0 lymph node status (no metastasis) and smaller tumor size (T 1 or T 2 ). Additionally, a 12-gene signature correctly predicts the stage of 94.2% of patients. Conclusions: Our results show that the prediction models based on the expression levels of a small number of marker genes could accurately predict patient outcome for individualized therapy of lung adenocarcinoma. Such an individualized treatment may significantly increase survival due to the optimization of treatment procedures and improve lung cancer survival every year through the 5-year checkpoint.

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“…Furthermore, PTPL1 has been implicated in the regulation of cytokinesis in HeLa cells, 32 and in the control of the meiotic cell cycle, 33 clearly supporting its importance in cell growth regulation. More recently, Zhu et al 34 demonstrated that PTPL1 can inhibit HER2/Neu, a signaling pathway that is frequently deregulated in breast cancer.…”

mentioning

confidence: 81%

Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer

Révillion

Puech

Rabenoelina

et al. 2008

Intl Journal of Cancer

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Although it is well established that some protein tyrosine kinases have a prognostic value in breast cancer, the involvement of protein tyrosine phosphatases (PTPs) is poorly substantiated for breast tumors. Three of these enzymes (PTP-gamma, LAR, and PTPL1) are already known to be regulated by estrogens or their antagonists in human breast cancer cells. We used a real-time reverse transcriptase polymerase chain reaction method to test the expression levels of PTP-gamma, LAR and its neuronal isoform, and PTPL1 in a training set of RNA from 59 breast tumors. We sought correlations between levels of these molecular markers, current tumor markers, and survival. We then quantified the expression level of the selected phosphatase in 232 additional samples, resulting in a testing set of 291 breast tumor RNAs from patients with a median follow-up of 6.4 years. The Spearman nonparametric test revealed correlations between PTPL1 expression and differentiation markers. Cox univariate analysis of the overall survival studies demonstrated that PTPL1 is a prognostic factor [risk ratio (RR) 5 0.45], together with the progesterone receptor (PR) (RR 5 0.52) and node involvement (RR 5 1.58). In multivariate analyses, PTPL1 and PR retained their prognostic value (RRs of 0.48 and 0.55, respectively). This study demonstrates for the first time that PTPL1 expression level is an independent prognostic indicator of favorable outcome for patients with breast cancer. In conjunction with our mechanistic studies, this finding identifies PTPL1 as an important regulatory element of human breast tumor aggressiveness and sensitivity to treatments such as antiestrogens and antiaromatase.

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Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation

Cited by 14 publications

References 41 publications

Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells

Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells

Constructing Molecular Classifiers for the Accurate Prognosis of Lung Adenocarcinoma

Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer

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