Potential role of Schwann cells in neuropathic pain

Zhang, Wenjun; Liu, Si-cheng; Ming, Li-guo; Yu, Jia-Kuo; Zuo, Cheng; Hu, Dongxia; Luo, Haiwei; Zhang, Qiao

doi:10.1016/j.ejphar.2023.175955

Cited by 9 publications

(5 citation statements)

References 157 publications

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“…У місці травми дедиференційовані шваннівські клітини видаляють залишки дегенеруючих аксонів та мієліну (аутофагія, мієлінофагія) [3,[18][19]. Крім того, під час цієї фази нейролеммоцити, вивільняючи хемоаттрактанти та запальні цитокіни (хемотаксичний білок моноцитів 1 (MCP1), фактор некрозу пухлини α (TNFα) та інтерлейкін-1), залучають макрофаги для фагоцитозу залишків мієліну [20][21]. Інтерлейкіни стимулюють проліферацію як новоутворених шваннівських клітин, так і сприяють проліферації та організації новоутворених аксонів та клітин фібробластичного ряду [14].…”

Section: основна частинаunclassified

“…Отже, вони обумовлюють видовження аксонів в ендоневральні трубки дистальних відділів травмованих нервів і вздовж нихдо денервованих органів-мішеней [23][24]. Дедиференційовані шваннівські клітини секретують різні нейротрофічні фактори, як от нейротрофічний фактор головного мозку (BDNF), фактор росту нервів (NGF), нейротрофічний фактор 3 та матриксні металопротеїнази, які відіграють захисну та трофічну роль у нейроні [8,17,[20][21]. Фактори росту, синтезовані немієлізуючими шваннівськими клітинами на додаток до факторів, що продукуються органами-мішенями, потенціюють ріст нових аксональних зачатків із проксимального аксонального сегмента [14].…”

Section: основна частинаunclassified

“…Дедиференційовані нейролемоцити активують вроджені імунні відповіді [12], що дає змогу репаруючим шваннівським клітинам координувати свої дії з імунними клітинами для створення оптимальних умов для покращення регенерації периферичних нервів [11,27]. На пізній стадії репаративної фази знижується експресія шваннівськими клітинами численних нейротрофічних факторів, що згодом призводить до диференціації останніх у напрямку мієлінізуючого фенотипу для можливості утворення нової мієлінової оболонки навколо регенерованих аксонів [20,28].…”

Section: основна частинаunclassified

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The Schwann Cells’ Role in Peripheral Nerve Regeneration (Molecular and Morphological Aspects)

Grabovyi,

Yaremenko,

Luzan

et al. 2024

Clin. and experim. pathol.

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The purpose of the work – to analyze data of modern scientific literature regarding thedetermination of the role of Schwann cells in the regeneration of the peripheral nerve.Conclusions. 1. Dysfunction of Schwann cells is an important factor in the delay, and insome cases, the absence of recovery of function after peripheral nerve injuries. 2. Moderntreatment should be aimed at activating the repair program in Schwann cells, initiatingthe recruitment of macrophages, stimulating the synthesis of neurotrophic factors byneuroleumocytes and macrophages, optimizing metabolism and the immune response incase of traumatic damage to main nerve trunks. 3. The use of genetic engineering toinfluence the genes that regulate the activity of Schwann cells during injuries may bea promising strategy in the treatment of this nosology. 4. The regenerative potential ofSchwann cells is inspires hope for a significant expansion of therapeutic possibilities inthe treatment of peripheral nerve injuries in the future.

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Section: основна частинаunclassified

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The Schwann Cells’ Role in Peripheral Nerve Regeneration (Molecular and Morphological Aspects)

Grabovyi,

Yaremenko,

Luzan

et al. 2024

Clin. and experim. pathol.

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“…Each SC form retains the ability to switch between phenotypes in response to environmental signals and appropriate cues [152]. While the different SC phenotypes can provide a broad range of functions that can contribute to the protection and repair of the nervous system, specific SC states are also associated with the initiation of pathological processes, including neuropathies, chronic pain [155], and tumorigenesis [156,157]. The distinction between the beneficial and pathological actions of the different phenotypes of SCs appears to be related to the EVs they produce, and more specifically, the microRNA cargos these SCEVs carry.…”

Section: Limitations Of Scevs As a Therapeutic Modality For Nervous S...mentioning

confidence: 99%

Schwann Cell-Derived Exosomal Vesicles: A Promising Therapy for the Injured Spinal Cord

Ghosh,

Pearse

2023

IJMS

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Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular milieu. Within these nanovesicles reside a multitude of bioactive molecules, which orchestrate essential biological processes, including cell differentiation, proliferation, and survival, in the recipient cells. These bioactive properties of exosomes render them a promising choice for therapeutic use in the realm of tissue regeneration and repair. Exosomes possess notable positive attributes, including a high bioavailability, inherent safety, and stability, as well as the capacity to be functionalized so that drugs or biological agents can be encapsulated within them or to have their surface modified with ligands and receptors to imbue them with selective cell or tissue targeting. Remarkably, their small size and capacity for receptor-mediated transcytosis enable exosomes to cross the blood–brain barrier (BBB) and access the central nervous system (CNS). Unlike cell-based therapies, exosomes present fewer ethical constraints in their collection and direct use as a therapeutic approach in the human body. These advantageous qualities underscore the vast potential of exosomes as a treatment option for neurological injuries and diseases, setting them apart from other cell-based biological agents. Considering the therapeutic potential of exosomes, the current review seeks to specifically examine an area of investigation that encompasses the development of Schwann cell (SC)-derived exosomal vesicles (SCEVs) as an approach to spinal cord injury (SCI) protection and repair. SCs, the myelinating glia of the peripheral nervous system, have a long history of demonstrated benefit in repair of the injured spinal cord and peripheral nerves when transplanted, including their recent advancement to clinical investigations for feasibility and safety in humans. This review delves into the potential of utilizing SCEVs as a therapy for SCI, explores promising engineering strategies to customize SCEVs for specific actions, and examines how SCEVs may offer unique clinical advantages over SC transplantation for repair of the injured spinal cord.

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“…The amazing plasticity of denervated Schwann cells to adapt to the new situation, irrespective of being myelinating and non-myelinating (Remak) cells, should be highlighted, particularly concerning the large and small diameter axons and their regenerative capacity. The Schwann cells differ in their adaptive response to injury and their potential to promote regeneration as well as their role in development of neuropathic pain [103]. The potential and involved mechanisms have been described extensively in reviews [21,26,104].…”

Section: The Schwann Cell After Injurymentioning

confidence: 99%

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

Dahlin

2023

IJMS

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Appropriate animal models, mimicking conditions of both health and disease, are needed to understand not only the biology and the physiology of neurons and other cells under normal conditions but also under stress conditions, like nerve injuries and neuropathy. In such conditions, understanding how genes and different factors are activated through the well-orchestrated programs in neurons and other related cells is crucial. Knowledge about key players associated with nerve regeneration intended for axonal outgrowth, migration of Schwann cells with respect to suitable substrates, invasion of macrophages, appropriate conditioning of extracellular matrix, activation of fibroblasts, formation of endothelial cells and blood vessels, and activation of other players in healthy and diabetic conditions is relevant. Appropriate physical and chemical attractions and repulsions are needed for an optimal and directed regeneration and are investigated in various nerve injury and repair/reconstruction models using healthy and diabetic rat models with relevant blood glucose levels. Understanding dynamic processes constantly occurring in neuropathies, like diabetic neuropathy, with concomitant degeneration and regeneration, requires advanced technology and bioinformatics for an integrated view of the behavior of different cell types based on genomics, transcriptomics, proteomics, and imaging at different visualization levels. Single-cell-transcriptional profile analysis of different cells may reveal any heterogeneity among key players in peripheral nerves in health and disease.

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Potential role of Schwann cells in neuropathic pain

Cited by 9 publications

References 157 publications

The Schwann Cells’ Role in Peripheral Nerve Regeneration (Molecular and Morphological Aspects)

The Schwann Cells’ Role in Peripheral Nerve Regeneration (Molecular and Morphological Aspects)

Schwann Cell-Derived Exosomal Vesicles: A Promising Therapy for the Injured Spinal Cord

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

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