Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death

Ahmed, Sahabuddin; Kwatra, Mohit; Gawali, Basveshwar; Panda, Samir Ranjan; Naidu, V.G.M.

doi:10.1007/s10495-020-01645-x

Cited by 42 publications

(24 citation statements)

References 56 publications

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“…In that study, vildagliptin suppressed 3-NP-induced striatal degeneration by restoring AKT, CREB, BDNF, GABA, Srt-1, and Nrf2 and suppressing MDA, glutamate and GFAP. In line with the protective effect of the TrkB agonist 7,8-DHF in previous AD and PD studies, recent observations demonstrated its protective effects in experimental animal models of 3-NP-induced HD by promoting the activation of CREB and AKT and suppressing neuronal death [168].…”

Section: Experimental Animal Models Of Hdsupporting

confidence: 73%

The Role of Microglia in the Development of Neurodegenerative Diseases

et al. 2021

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Microglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial activation. In this review, we summarize the contribution of microglial activation and its associated mechanisms in NDs, such as epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), based on recent observations. This review also briefly introduces experimental animal models of epilepsy, AD, PD, and HD. Thus, this review provides a better understanding of microglial functions in the development of NDs, suggesting that microglial targeting could be an effective therapeutic strategy for these diseases.

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Section: Experimental Animal Models Of Hdsupporting

confidence: 73%

The Role of Microglia in the Development of Neurodegenerative Diseases

et al. 2021

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“…PI3K activity leads to the activating phosphorylation of Akt, a serine-threonine kinase crucially involved in cell survival and growth [ 6 ]. For instance, Akt suppressed BAD activity, inhibiting the promotion of signaling cascades involved in apoptosis [ 44 ].…”

Section: Neurotrophins: From Cell Signaling To Metabolic Processesmentioning

confidence: 99%

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Colardo

Martella

Pensabene

et al. 2021

IJMS

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Neurotrophins constitute a family of growth factors initially characterized as predominant mediators of nervous system development, neuronal survival, regeneration and plasticity. Their biological activity is promoted by the binding of two different types of receptors, leading to the generation of multiple and variegated signaling cascades in the target cells. Increasing evidence indicates that neurotrophins are also emerging as crucial regulators of metabolic processes in both neuronal and non-neuronal cells. In this context, it has been reported that neurotrophins affect redox balance, autophagy, glucose homeostasis and energy expenditure. Additionally, the trophic support provided by these secreted factors may involve the regulation of cholesterol metabolism. In this review, we examine the neurotrophins’ signaling pathways and their effects on metabolism by critically discussing the most up-to-date information. In particular, we gather experimental evidence demonstrating the impact of these growth factors on cholesterol metabolism.

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“…It is involved in regulating the growth and survival of existing neurons, as well as the growth and differentiation of new neurons and synapses. In addition, BDNF plays an active role in learning, memory, and sensory-motor recovery by promoting the plasticity of synapses and axons [ 28 ]. The PI3K/Akt signaling pathway is closely related to BDNF.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the effects of high cervical spinal cord electrical stimulation on improving neurological dysfunction and its potential mechanism in rats with traumatic brain injury

Zhao

Huang²,

Xu³

et al. 2022

NeuroReport

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To explore the effects of high cervical spinal cord electrical stimulation (cSCS) on the recovery of neurological function and its possible mechanism in rats with traumatic brain injury (TBI). 72 rats were randomly divided into: (1) a sham group; (2) a traumatic brain injury (TBI) group; (3) a TBI+cSCS group; (4) a LY294002+TBI+cSCS group. The degree of neurological dysfunction was evaluated by modified Neurological severity score (mNSS). The pathological changes of the brain tissue in the injured area were observed by HE staining, and the apoptosis of neuron cells were observed by TUNEL staining. The expressions of BDNF and VEGFmRNA were detected by polymerase chain reaction (PCR), and the expressions of p-AKT, AKT, Bcl-2, Bax and caspase-3 proteins were detected by western blot. Compared with that of the TBI and LY294002+TBI+cSCS groups, the mNSS of the TBI+cSCS group were significantly lower on day 3 and 7 ( P <0.05). Compared with that in the TBI and LY294002+TBI+cSCS groups, the apoptosis of neuron cells in the TBI+cSCS group decreased significantly ( P < 0.05). Compared with the TBI and LY294002+TBI+cSCS group, the expression of Bcl-2 protein increased and the expressions of Bax and Caspase-3 proteins decreased in the TBI+cSCS group ( P < 0.05). Compared with that in the TBI and LY294002+TBI+cSCS groups, the intensity of p-Akt/Akt in the TBI+cSCS group increased ( P < 0.05). We found that cSCS had a protective effect on neuron cells after craniocerebral injury and could improve neurological dysfunction in rats, the mechanism of which might be that cSCS made the PI3K/Akt pathway more active after TBI.

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Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death

Cited by 42 publications

References 56 publications

The Role of Microglia in the Development of Neurodegenerative Diseases

The Role of Microglia in the Development of Neurodegenerative Diseases

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Investigation of the effects of high cervical spinal cord electrical stimulation on improving neurological dysfunction and its potential mechanism in rats with traumatic brain injury

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