Potential role of Vitamin D in immune response in patients with viral hepatitis

Gerhards, Catharina; Teufel, Andreas; Gerigk, Marlis; French, Michael; Antoni, Christoph; Ebert, Matthias; Neumaier, Michael; Evliyaoglu, Osman

doi:10.1016/j.nut.2024.112447

Nutrition

2024

DOI: 10.1016/j.nut.2024.112447

|View full text |Cite

Potential role of Vitamin D in immune response in patients with viral hepatitis

Catharina Gerhards,

Andreas Teufel,

Marlis Gerigk

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection

da Silva,

Caetano,

Mendonça

et al. 2024

The Journal of Applied Laboratory Medicine

View full text Add to dashboard Cite

Background Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB). Methods 126 CHB patients were enrolled in the current study and clinical, laboratory, and 25-hydroxyvitamin D [25(OD)D] level data were obtained. Four VDR (rs7975232, rs1544410, rs10735810, rs731236) and 2 vitamin D-binding protein/carrier globulin (GC) polymorphisms (rs4588 and rs7041) were determined using TaqMan assays and nucleotide sequencing. Association studies were conducted among viral infection parameters and the patient's genetic variants. Results Most patients were male (52.38%) with a mean age of 44.28 (±14.24) years, self-identified as White (32.54%), and exhibited vitamin D insufficiency status (42.06%). The hepatitis B virus (HBV) genotype A was predominant (50%) and 62.7% of the patients had detectable HBV DNA levels ≤log10 3 IU/mL. A significant association was observed between HBV genotype A with ApaI and FokI single nucleotide polymorphisms. However, no statistical association between VDR polymorphisms and viral load, viral polymerase mutations, or vitamin D status was found. Vitamin D concentration did not correlate to HBV viral load. Conclusions Most HBV-infected individuals presented vitamin D insufficiency, and VDR polymorphism was not associated with virological characteristics except with HBV genotype A, demonstrating that some human genetic signatures are related to HBV genotype distribution.

show abstract

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection

da Silva,

Caetano,

Mendonça

et al. 2024

The Journal of Applied Laboratory Medicine

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Potential role of Vitamin D in immune response in patients with viral hepatitis

Cited by 1 publication

References 37 publications

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection

Contact Info

Product

Resources

About