Potential roles of hyaluronic acid in <i>in vivo</i> CAR T cell reprogramming for cancer immunotherapy

Laomeephol, Chavee; Areecheewakul, Sudartip; Tawinwung, Supannikar; Suppipat, Koramit; Chunhacha, Preedakorn; Neves, Nuno M.; Luckanagul, Jittima Amie

doi:10.1039/d2nr05949e

Cited by 4 publications

(1 citation statement)

References 143 publications

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“…However, this approach can also lead to cell death because of disruption of the cell membrane. Shielding or polyelectrolytic complexing with anionic HA can reverse these negative effects, and HA can also mediate cellular uptake through receptor-mediated endocytosis [ 116 ].…”

Section: Potential Therapeutic or Theranostic Applications Of Hyaluro...mentioning

confidence: 99%

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Myint,

Laomeephol,

Thamnium

et al. 2023

Pharmaceutics

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Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels exhibit excellent colloidal stability and high encapsulation capacity, making them promising tools for a wide range of biomedical applications. HA nanogels can be fabricated using various methods, including polyelectrolyte complexation, self-assembly, and chemical crosslinking. The fabrication parameters can be tailored to control the physicochemical properties of HA nanogels, such as size, shape, surface charge, and porosity, enabling the rational design of HA nanogels for specific applications. Stimulus-responsive nanogels are a type of HA nanogels that can respond to external stimuli, such as pH, temperature, enzyme, and redox potential. This property allows the controlled release of encapsulated therapeutic agents in response to specific physiological conditions. HA nanogels can be engineered to encapsulate a variety of therapeutic agents, such as conventional drugs, genes, and proteins. They can then be delivered to target tissues with high efficiency. HA nanogels are still under development, but they have the potential to become powerful tools for a wide range of theranostic or solely therapeutic applications, including anticancer therapy, gene therapy, drug delivery, and bioimaging.

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Section: Potential Therapeutic or Theranostic Applications Of Hyaluro...mentioning

confidence: 99%

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Myint,

Laomeephol,

Thamnium

et al. 2023

Pharmaceutics

Self Cite

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Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy

Wang,

Pang,

Liu

et al. 2024

International Journal of Biological Macromolecules

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Targeted gene delivery through receptors with lipid nanoparticles

Muripiti,

Velidandia,

Sharma

et al. 2024

Journal of Drug Delivery Science and Technology

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Potential roles of hyaluronic acid in in vivo CAR T cell reprogramming for cancer immunotherapy

Abstract: Chimeric antigen receptor (CAR) T cell therapy has recently shown unprecedented clinical efficacy for cancer treatment, particularly hematological malignancies. However, the complex manufacturing processes that involve ex vivo genetic modification...

Cited by 4 publications

References 143 publications

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy

Targeted gene delivery through receptors with lipid nanoparticles

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