Oilseed flax at the beginning of vegetation is strongly suppressed by weeds, so the choice of optimal and effective herbicide is one of the factors of high productivity of its crops. In this work, the efficiency of application of tank mixtures of seven herbicides on oilseed flax varieties Vnimk 620 and Itil was evaluated in the production experiment in the farm in Penza region. Biological efficiency of the preparations and economic efficiency of their application in the conditions of the region were evaluated. When using a tank mixture of Gerbitoks-L, WSC + Kvikstep, EOO, almost complete destruction of dicotyledonous and cereal weeds (90.94%) in the crops of both varieties of flax was achieved and economic profitability of 55.9% was ensured. For effective control of weeds in oilseed flax crops under conditions of Penza region it is recommended to use tank mixture of herbicides Gerbitoks-L, WSC + Kvikstep, EOO at a rate of 1.5+0.8 l/ha.