Potential Similarities in Temporal Lobe Epilepsy and Alzheimer’s Disease

Li, Bin-Yin; Chen, Shengdi

doi:10.1177/1533317514537547

Cited by 11 publications

(6 citation statements)

References 74 publications

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“… 9 , 10 In addition, a patient presenting with insidious onset of cognitive decline may actually be suffering from temporal lobe epilepsy, which thus mimics dementia. 11 , 12 In this specific situation, EEG is the key to confirming the diagnosis. Therefore, in the case under consideration in the present study, NCS was diagnosed through a detailed recording of the patient’s medical history, physical and neurological examinations, and the use of EEG with sphenoidal electrodes.…”

Section: Discussionmentioning

confidence: 99%

Dementia with non-convulsive seizures: a case report

Chen

Huang

2021

J Int Med Res

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Non-convulsive seizures (NCSs) are highly treatable, but appropriate management is usually delayed because of inaccurate diagnoses as a result of variable clinical presentations, including an altered mental state. It is difficult to detect NCSs in patients with dementia. We report a case of NCS superimposed on cognitive decline caused by Alzheimer’s dementia. The patient’s history was carefully recorded. An electroencephalogram was recorded with sphenoidal electrodes, which showed epileptiform discharges in the right mesial temporal lobe and focal, sharply contoured, slow wave activity in the left fronto-temporal area, suggesting an epileptic origin contributing to the patient’s cognitive decline. After treatment with antiepileptic drugs, the patient’s cognitive functioning gradually improved. An accurate diagnosis of NCS relies on performing a detailed inventory of a patient’s history, thorough physical and neurological examinations, and electroencephalogram recordings. In patients with cognitive decline, testing for NCS should always be included in the differential diagnosis of cognitive impairment, even in the case of dementia. Early administration of antiepileptic drug therapy is the mainstay treatment for reversing the condition and for preventing prolonged insults from neurological sequelae.

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Section: Discussionmentioning

confidence: 99%

Dementia with non-convulsive seizures: a case report

Chen

Huang

2021

J Int Med Res

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“…It is well known that the temporal lobe consists of structures that are vital for long-term memory. There are numerous reports that the temporal lobe including the left, medial, and right temporal lobes are involved in AD pathology (Kakeda and Korogi, 2010; Li and Chen, 2015; Menéndez-González et al, 2015; Aggleton et al, 2016; Delgado-González et al, 2017; Pettigrew et al, 2017; Wolk et al, 2017; Jung et al, 2018; Kitchigina, 2018; Persson et al, 2018; Grajski and Bressler, 2019; Kenkhuis et al, 2019; Lam et al, 2019; Pasquini et al, 2019; Xie et al, 2019). DTI discovered the functional and structural connectivity between the medial temporal lobe (MTL) and posteromedial cortex (PMC) (Buckner et al, 2008; Pasquini et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Deep Feature Selection and Causal Analysis of Alzheimer’s Disease

Liu

et al. 2019

Front. Neurosci.

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Deep convolutional neural networks (DCNNs) have achieved great success for image classification in medical research. Deep learning with brain imaging is the imaging method of choice for the diagnosis and prediction of Alzheimer’s disease (AD). However, it is also well known that DCNNs are “black boxes” owing to their low interpretability to humans. The lack of transparency of deep learning compromises its application to the prediction and mechanism investigation in AD. To overcome this limitation, we develop a novel general framework that integrates deep leaning, feature selection, causal inference, and genetic-imaging data analysis for predicting and understanding AD. The proposed algorithm not only improves the prediction accuracy but also identifies the brain regions underlying the development of AD and causal paths from genetic variants to AD via image mediation. The proposed algorithm is applied to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset with diffusion tensor imaging (DTI) in 151 subjects (51 AD and 100 non-AD) who were measured at four time points of baseline, 6 months, 12 months, and 24 months. The algorithm identified brain regions underlying AD consisting of the temporal lobes (including the hippocampus) and the ventricular system.

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“…[7][8] AD is clinically characterized by insidious onset of memory and cognitive impairments, which are also presented in patients with temporal lobe epilepsy. 9 Several questions remain unanswered about the occurrence of seizures in AD. Like for example, do epilepsy and AD share pathophysiology?…”

Section: Discussionmentioning

confidence: 99%

Correlation of medial temporal lobe atrophy with seizures in Alzheimer’s disease and mild cognitive impairment: A case control study

Dhikav

Duraisawmy

Anand

2017

International Journal of Epilepsy

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Background Seizures are common accompaniment of neurodegenerative disease. Though, Alzheimer’s disease (AD) is the most common cause, but seizures also occasionally occur in mild cognitive impairment (MCI). Material & methods We studied patients of Subjective Memory Complaints coming to the Department of Neurology of a Tertiary Care Hospital in Northern India from July 2012 to July 2015. A total of 171 patients were studied. Those with a diagnosis of AD/MCI with seizures were taken for the current study. A total of 30 controls with chronic diseases were taken for comparison. Medial Temporal Lobe Atrophy (MTA) Rating was done using Sheleten’s Visual Rating Scale. Results A total of 256 patients were screened and 171 had dementia of Alzheimer’s type (n = 75; M:F = 60:15) and 96 patients had MCI (M:F = 76:20). The mean MMSE of those with AD was 18.5 ± 3.3 was and that of the MCI was 26.6 ± 2.4. A total of 9 cases with AD had seizures and 6 had seizures in MCI group (total n = 15). Moderately strong correlation was obtained between MMSE of AD patients having seizures and MTA scoring. Conclusions Seizures are common in dementia of Alzheimer’s type and not uncommon in MCI. They have the potential to worsen the cognitive profile of the patient and need attention in these patients.

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Potential Similarities in Temporal Lobe Epilepsy and Alzheimer’s Disease

Cited by 11 publications

References 74 publications

Dementia with non-convulsive seizures: a case report

Dementia with non-convulsive seizures: a case report

Deep Feature Selection and Causal Analysis of Alzheimer’s Disease

Correlation of medial temporal lobe atrophy with seizures in Alzheimer’s disease and mild cognitive impairment: A case control study

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