Potential Sources of Bisphenol A in the Neonatal Intensive Care Unit

Duty, Susan; Mendonca, K.; Hauser, Russ; Calafat, Antònia M.; Ye, Xiaoyun; Meeker, John D.; Ackerman, Robin M.; Cullinane, Judi; Faller, Josephine; Ringer, Steven A.

doi:10.1542/peds.2012-1380

Cited by 80 publications

(75 citation statements)

References 19 publications

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“…The use of polycarbonated cages and water bottles, as in this study, may have introduced a background exposure to BPA (Howdeshell et al 2003, Le et al 2008, Duty et al 2013, which could have affected the biological endpoints. Background exposure to BPA or other possible EDCs present in water bottles or cages was not controlled in this study.…”

Section: Endocrine Disruption: Effects In Aging Ratsmentioning

confidence: 97%

Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters

et al. 2014

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This study examined late-life effects of perinatal exposure of rats to a mixture of endocrine-disrupting contaminants. Four groups of 14 time-mated Wistar rats were exposed by gavage from gestation day 7 to pup day 22 to a mixture of 13 anti-androgenic and estrogenic chemicals including phthalates, pesticides, u.v.-filters, bisphenol A, parabens, and the drug paracetamol. The groups received vehicle (control), a mixture of all 13 chemicals at 150-times (TotalMix150) or 450-times (TotalMix450) high-end human exposure, or 450-times a mixture of nine predominantly anti-androgenic chemicals (AAMix450). Onset of puberty and estrous cyclicity at 9 and 12 months of age were assessed. Few female offspring showed significantly regular estrus cyclicity at 12 months of age in the TotalMix450 and AAMix450 groups compared with controls. In 19-month-old male offspring, epididymal sperm counts were lower than controls, and in ventral prostate an overrepresentation of findings related to hyperplasia was observed in exposed groups compared with controls, particularly in the group dosed with anti-androgens. A higher incidence of pituitary adenoma at 19 months of age was found in males and females in the AAMix450 group. Developmental exposure of rats to the highest dose of a human-relevant mixture of endocrine disrupters induced adverse effects late in life, manifested as earlier female reproductive senescence, reduced sperm counts, higher score for prostate atypical hyperplasia, and higher incidence of pituitary tumors. These delayed effects highlight the need for further studies on the role of endocrine disrupters in hormone-related disorders in aging humans.

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Section: Endocrine Disruption: Effects In Aging Ratsmentioning

confidence: 97%

Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters

et al. 2014

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“…Bisphenol A (BPA) is used in the manufacture of polycarbonate used for plastic products such as drinking bottles, toys, and medical devices and in epoxy resins used to line food/beverage containers and electronic devices (Rubin 2011, Duty et al 2013. Phenols such as triclosan (TCS) and triclocarban (TCC) are used as antibacterial agents in a range of personal care products such as soaps, toothpaste, deodorants, and disinfectants (Dann & Hontela 2011).…”

Section: Introductionmentioning

confidence: 99%

Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012

Frederiksen¹,

Jensen²,

Jørgensen³

et al. 2014

Reproduction

199

100

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Several non-persistent industrial chemicals have shown endocrine disrupting effects in animal studies and are suspected to be involved in human reproductive disorders. Among the non-persistent chemicals that have been discussed intensively during the past years are phthalates, bisphenol A (BPA), triclosan (TCS), and parabens because of their anti-androgenic and/or estrogenic effects. Phthalates are plasticizers used in numerous industrial products. Bisphenol A is the main component of polycarbonate plastics and epoxy resins. Parabens and TCS are antimicrobial preservatives and other phenols such as benzophenone-3 (BP-3) act as a UV-screener, while chlorophenols and phenyl phenols are used as pesticides and fungicides in agriculture. In spite of the widespread use of industrial chemicals, knowledge of exposure sources and human biomonitoring studies among different segments of the population is very limited. In Denmark, we have no survey programs for non-persistent environmental chemicals, unlike some countries such as the USA (NHANES) and Germany (GerES). However, we have analyzed the excretion of seven parabens, nine phenols, and the metabolites of eight different phthalates in urine samples collected over the past 6 years from four Danish cohorts. Here, we present biomonitoring data on more than 3600 Danish children, adolescents, young men, and pregnant women from the general population. Our study shows that nearly all Danes were exposed to the six most common phthalates, to BPA, TCS, and BP-3, and to at least two of the parabens. The exposure to other non-persistent chemicals was also widespread. Our data indicate decreasing excretion of two common phthalates (di-n-butyl phthalate and di-(2-ethylhexyl) phthalate) over time.

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“…Among these contaminants, bisphenol A (BPA) is a ubiquitous xenoestrogen and a raw material widely used in the manufacturing of a variety of consumer goods such as canned food and drink [2], thermal printer paper [3], and even medical equipment [4]. Since its first commercial use in 1950s, the global consumption of BPA is continuously growing with an increase from 3.9 million tons in 2006 to nearly 5 million tons in 2010 [5].…”

Section: Introductionmentioning

confidence: 99%

Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure

Xü

Fan

et al. 2016

Mol Neurobiol

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During early development, continuous exposure to environmental contaminants such as bisphenol A (BPA) is known to alter neuronal development, resulting in aberrant brain structure and predisposing individuals to developing neuropsychiatric disorders later in life. While the altered oligodendrocyte (OL) structure and function have been casually linked to the occurrence of numerous psychiatric diseases, it remains open whether early BPA exposure (EBE) also recruits OLs to mediate its toxicity in the brain. Here, we observed that EBE from birth to postnatal day 21 caused a substantial loss of hippocampal OLs in rat pups. The OL loss was enduring and manifested even when the affected pups spanned into their adulthood. In parallel, the expression of two key proteins in mature OLs, myelin basic protein (MBP), and monocarboxylate transporter 1 (MCT1) was markedly downregulated in adult hippocampus with a considerable reduction in the number of myelinated axons. By contrast, the myelination of individual axons remained intact. The altered hippocampal OLs were related to EBE-mediated disruption of estrogen receptor (ER) signaling in developing OLs and could be readily prevented by treatment with low level of ICI 182780, an ER antagonist. Importantly, the adult rats subject to EBE exhibited clear deficit in contextual fear memory, which highly correlated with OL loss and decreased MBP and MCT1 expression in hippocampus. The OL loss may thus represent an alternative route through which EBE has its adversity on the brain and contributes to the development of neuropsychiatric illness.

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Potential Sources of Bisphenol A in the Neonatal Intensive Care Unit

Cited by 80 publications

References 19 publications

Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters

Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters

Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012

Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure

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