Potential strategies for preventing chronic postoperative pain: a practical approach: Continuing Professional Development

Richebé, Philippe; Julien, Marco; Brulotte, Véronique

doi:10.1007/s12630-015-0499-4

Cited by 32 publications

(30 citation statements)

References 58 publications

(122 reference statements)

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“…Our results also indicate that that the expression of IL‐6, TNF‐α, and COX‐2 was significantly altered in adolescents with CFS, and was associated with comorbidities, pain intensity, pain frequency, and functional pain inference with general activity, mood, and school attendance . Several studies have reported higher concentrations of IL‐6, TNF‐α, and COX‐2 following acute or chronic pain . The data obtained in our present study also indicate that both the COX‐2 pathway and the immune cell balance effect are involved in pain‐induced inflammation in patients with CFS …”

Section: Discussionsupporting

confidence: 80%

“…Only 8 participants were excluded from this study. Using previously reported criteria for the diagnosis of CFS, adolescents were classified into 2 groups—adolescents with CFS ( n = 100) and HCs ( n = 50)—as reported in the flow diagram (Figure ). In this study, we included adolescents with CFS who were taking no prescribed drugs (including hormone contraceptives); had no medical or psychiatric disorders that might account for the fatigue; and who had a constant or persisting fatigue lasting 3 months with severe functional disability that prevented normal school attendance.…”

Section: Methodsmentioning

confidence: 99%

“…The protein expression of COX‐2, TNF‐α, and IL‐6 were shown to be associated with chronic pain in many studies . Thus, in this study, all participants were assessed for estimation of COX‐2, TNF‐α, and IL‐6 in serum samples using a commercially available Quantikine enzyme‐linked immunosorbent kit (ELISA; R&D Systems, Minneapolis, MN, U.S.A.).…”

Section: Methodsmentioning

confidence: 99%

“…In patients with chronic pain, cyclooxygenase catalyzes the transformation of arachidonic acid into prostaglandins, which are key mediators of the exaggerated sensation of pain . Also, several studies have reported higher concentrations of interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and COX‐2 following acute or chronic pain . In addition, the expression levels of the miRNAs miR‐558, miR‐146a, miR‐150, miR‐124, and miR‐143 were reported in older patients with CFS, but it is not known whether the proposed miRNAs are expressed or have a role in adolescence with CFS.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome

2019

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Background Numerous experimental models have shown that microRNAs (miRNAs)play an important role in regulating pain processing in clinical pain disorders. In this study, we evaluated a set of miRNAs as diagnostic biomarkers of pain intensity in adolescents with chronic fatigue syndrome (CFS). We then correlated the expression of these miRNAs with the levels of inflammatory markers and pain‐related comorbidities in adolescents with CFS and healthy controls (HCs). Methods A total of 150 adolescents, 12 to 18 years of age, participated in this study between April 2016 and April 2017. The participants were classified into 2 groups: adolescents with CFS (n = 100) and HCs (n = 50). Reverse‐transcription polymerase chain reaction was used to evaluate the expression of miR‐558, miR‐146a, miR‐150, miR‐124, and miR‐143. Immunoassay analysis was used to assess the levels of immune inflammatory markers interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and cyclooxygenase‐2 (COX‐2). Results Adolescents with CFS showed significantly higher pain thresholds than comparable nonfatigued HCs. Ability to enjoy life and relations with others were the parameters least influenced by pain in CFS patients. Differential expression of miR‐558, miR‐146a, miR‐150, miR‐124, and miR‐143 was significantly downregulated and notably interfered with pain intensity and frequency in patients with CFS. Also, the expression of these miRNAs was significantly correlated with that of IL‐6, TNF‐α, and COX‐2, which have been shown to mediate pain intensity in patients with CFS. Girls with CFS showed significantly decreased expression levels of these miRNAs compared with the levels of boys with CFS. Girls with CFS also showed increased expression of the inflammatory pain–related markers IL‐6, TNF‐α, and COX‐2 compared with the levels of boys with CFS. Conclusions The intensity and consequences of pain were influenced by differential expression of miR‐558, miR‐146a, miR‐150, miR‐124, and miR‐143, which was directly associated with higher expression of the immune inflammatory‐related genes TNFα, IL‐6, and COX‐2 in adolescents with CFS. Further studies of larger patient cohorts will help clarify the role of miRNAs in the pathogenesis of CFS.

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Section: Discussionsupporting

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome

2019

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“…Experts currently suggest that aggressive treatment of acute pain may have potential benefits in preventing the transition to persistent postsurgical pain. [30][31][32] …”

Section: Evaluating the Role Of New Interfascial Plane Blocksmentioning

confidence: 99%

Interfascial Plane Blocks

Elsharkawy

Pawa

Mariano

2018

Regional Anesthesia and Pain Medicine

177

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Ultrasound-guided interfascial plane blocks are a recent development in modern regional anesthesia research and practice and represent a new route of transmission for local anesthetic to various anatomic locations, but much more research is warranted. Before becoming overtaken with enthusiasm for these new techniques, a deeper understanding of fascial tissue anatomy and structure, as well as precise targets for needle placement, is required. Many factors may influence the ultimate spread and quality of resulting interfascial plane blocks, and these must be understood in order to best integrate these techniques into contemporary perioperative pain management protocols.

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Chronic postsurgical pain in children and young adults with cancer and choice of regional anesthesia for amputation and limb‐sparing surgery

et al. 2022

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Background: Patients undergoing limb amputation (LA) or limb-sparing (LS) for lower extremity oncologic diagnoses are at similar risk for chronic postsurgical pain of neuropathic nature (CPSP/NP). Regional anesthesia (RA) techniques are pre-emptive measures to prevent the occurrence of the CPS/NP. However, recommendations for epidural (EP) versus peripheral nerve blocks (PNBs) lack in pediatric literature.Aims: This study investigates the incidence and duration of CPSP/NP and describes NP-directed regimens.Methods and Results: Data on demographics, use of EP or PNB, duration of CPSP/NP, and NP-directed medication were retrospectively collected for LA and LS between 2009 and 2019. Mixed effects logistic regression was used to compare the odds of CPSP/NP between EP and PNB. Cox PH model with adjustment for clustering due to multiple surgeries on patients was used to quantify rate of pain relief between surgery groups (LA vs. LS) and RA groups (EP vs. PNB). The incidence of CPSP/NP was 36 (23.8%) after 165 surgeries (150 patients). The odds of CPSP/NP after PNB were 2.5 times those of CPSP/NP after EP (p = .11).The rate of pain relief at any instant after the EP was 1.2 times that after PNB (p = .3). The rate of pain relief for LS with EP was 1.9 times that of pain relief for LA with EP, a statistically significant difference (p = .03). Gabapentin was used (94.5%), with addition of amitriptyline (24.2%) and both amitriptyline and methadone (12.7%). Conclusion:The LS with the EP group had a significantly higher rate of relief of CPSP/NP than LA with EP. Odds of CPSP/NP after PNB were 2.5 times those of CPSP after EP.

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Potential strategies for preventing chronic postoperative pain: a practical approach: Continuing Professional Development

Cited by 32 publications

References 58 publications

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome

Interfascial Plane Blocks

Chronic postsurgical pain in children and young adults with cancer and choice of regional anesthesia for amputation and limb‐sparing surgery

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