Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract

Guo, Chuan‐Guo; Leung, Wai K.

doi:10.5009/gnl19201

Cited by 32 publications

(21 citation statements)

References 93 publications

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“…The NSAIDs that are currently available can be classified into two main families: Non-selective NSAIDs (nsNSAIDs) and selective COX-2 inhibitors (coxibs). According to their half-lives, nsNSAIDs can be classified further into two groups: Those with a short half-life (<6 h), including ibuprofen, and those with longer half-lives, including naproxen (19). Ibuprofen and naproxen are commonly used for dysmenorrhea in patients with adenomyosis.…”

Section: Introductionmentioning

confidence: 99%

Celecoxib, a selective COX‑2 inhibitor, markedly reduced the severity of tamoxifen‑induced adenomyosis in a murine model

Jin

Liu

et al. 2020

Exp Ther Med

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The aim of the present study was to evaluate the effects of the selective cyclooxygenase (COX)-2 inhibitor celecoxib on the development of uterine adenomyosis in mice. ICR neonatal mice were first exposed to tamoxifen to establish a mouse model of adenomyosis. Following 60 days of celecoxib treatment, pathological formation of adenomyosis lesions and the depth of myometrial infiltration were evaluated using hematoxylin and eosin staining. To examine thermal pain modulation in mice, a hotplate test was conducted every 15 days from postnatal day 30 onwards. Immunohistochemistry was performed to assess the expression of aromatase P450, N-cadherin, E-cadherin, COX-2 and cluster of differentiation 31, whereas the levels of estrogen were analyzed in uterine tissue homogenates using ELISA. Masson trichrome staining was performed to assess the extent of fibrosis in the uterus. Celecoxib treatment significantly inhibited the depth of infiltration into the myometrium, resulting in significantly reduced disease severity. Treatment with high doses of celecoxib significantly prolonged thermal response latency. Following celecoxib treatment, the expression of E-cadherin was significantly increased whereas the expression of N-cadherin was significantly decreased. Concomitantly, the extent of fibrosis was also reduced following celecoxib treatment. Uterine tissue homogenates isolated from mice treated with both high and low doses of celecoxib exhibited lower concentrations of estrogen and decreased expression of aromatase P450. These observations suggest that celecoxib reduces adenomyosis severity by suppressing estrogen production in the uterus, reversing epithelial-mesenchymal transition and relieving fibrosis. Taken together, the results of the present study support the potential use of celecoxib, a selective COX-2 inhibitor, for the treatment of adenomyosis.

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Section: Introductionmentioning

confidence: 99%

Celecoxib, a selective COX‑2 inhibitor, markedly reduced the severity of tamoxifen‑induced adenomyosis in a murine model

Jin

Liu

et al. 2020

Exp Ther Med

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“…Selective COX-2 inhibitors have satisfactory anti-inflammatory and analgesic effects, but they can also cause many adverse reactions, such as gastrointestinal events and cardiovascular disease [ 42–45 ]. Rofecoxib was withdrawn from the market in 2004 due to its significant gastrointestinal reactions and cardiovascular toxicity [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis

et al. 2020

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Objective To compare the efficacy and safety of celecoxib and diclofenac sodium in patients with knee osteoarthritis (KOA). Methods Clinical controlled trials (CCTs) and randomized controlled trials (RCTs) from online databases comparing the efficacy of celecoxib and diclofenac sodium in the treatment of KOA were retrieved. The main outcomes included the treatment effect, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), visual analog scale (VAS) score, and complication rate. The Cochrane risk of bias (ROB) tool in Review Manager 5.3.5 was used to assess methodological quality. Results Twelve studies (N = 2,350) were included in this meta-analysis. The meta-analysis indicated that celecoxib reduced pain more effectively than diclofenac sodium in patients with KOA, as evaluated by the VAS score. In addition, celecoxib has certain advantages in terms of better treatment effects and greater reductions in the ESR, CRP level, and complication rate. Conclusions Celecoxib is superior to diclofenac sodium in the treatment of KOA. However, well-designed and high-quality RCTs are still needed.

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“…Data from several laboratories indicate that NO-NSAIDs may be effective in many diseases, including cardiovascular [153], rheumatological [147,154] and pulmonary diseases [152], Alzheimer's disease [155] and cancer [150,156]. Numerous in vitro and animal studies have confirmed the enhanced safety profile of NO-NSAIDs in terms of anti-inflammatory efficacy, gastrointestinal and cardiovascular tolerance, and even heart protection compared to their NSAID parents, although there are also reports of severe side effects [157][158][159][160][161]. An excellent example of such a course of research is the research on the hybrid NO and aspirin (ASA) developed by NiCox in the form of three different isomers (NCX 4040, NCX 4016 and NCX 4012 as para-, meta-, and ortoisomers, (Figure 9).…”

Section: No As a Prodrugmentioning

confidence: 99%

Carbon Monoxide and Nitric Oxide as Examples of the Youngest Class of Transmitters

Nowaczyk

Kowalska

Nowaczyk

et al. 2021

IJMS

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The year 2021 is the 100th anniversary of the confirmation of the neurotransmission phenomenon by Otto Loewi. Over the course of the hundred years, about 100 neurotransmitters belonging to many chemical groups have been discovered. In order to celebrate the 100th anniversary of the confirmation of neurotransmitters, we present an overview of the first two endogenous gaseous transmitters i.e., nitric oxide, and carbon monoxide, which are often termed as gasotransmitters.

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Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract

Cited by 32 publications

References 93 publications

Celecoxib, a selective COX‑2 inhibitor, markedly reduced the severity of tamoxifen‑induced adenomyosis in a murine model

Celecoxib, a selective COX‑2 inhibitor, markedly reduced the severity of tamoxifen‑induced adenomyosis in a murine model

Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis

Carbon Monoxide and Nitric Oxide as Examples of the Youngest Class of Transmitters

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