Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning

Li, Hao; Bishop, Kathie M.; O’Leary, Dennis D.M.

doi:10.1016/j.mcn.2006.06.012

Cited by 55 publications

(83 citation statements)

References 47 publications

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“…The overall increase of E14.5 caudal gene expression almost reached statistical significance (GSA P = 0.06). The only caudal marker that exhibited a (slight) decrease of expression in E14.5 Tbr1 null cortex, Odz1, is expressed mainly in SP (25), and SP differentiation is severely defective in Tbr1 mutants (11). This observation illustrates one way in which regional and laminar identity may interact.…”

Section: Resultsmentioning

confidence: 79%

“…Because anatomical landmarks of cortical areas (e.g., somatosensory barrels) are not developed on P0.5, we assessed regional identity using molecular expression patterns (12,13). Previous studies have described several regional markers in embryonic and neonatal cortex, such as Bcl6 rostrally and Odz3 caudally (14,24,25). To find additional regional markers, we mined online databases (26)(27)(28), previous publications, and our microarray data (Dataset S1 and Dataset S2).…”

Section: Resultsmentioning

confidence: 99%

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Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

Bedogni¹,

Hodge

Elsen

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

297

336

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Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a transcription factor expressed in postmitotic projection neurons, exerts positive and negative control over both regional (areal) and laminar identity. Tbr1 null mice exhibited profound defects of frontal cortex and layer 6 differentiation, as indicated by down-regulation of gene-expression markers such as Bcl6 and Cdh9. Conversely, genes that implement caudal cortex and layer 5 identity, such as Bhlhb5 and Fezf2, were up-regulated in Tbr1 mutants. Tbr1 implements frontal identity in part by direct promoter binding and activation of Auts2, a frontal cortex gene implicated in autism. Tbr1 regulates laminar identity in part by downstream activation or maintenance of Sox5, an important transcription factor controlling neuronal migration and corticofugal axon projections. Similar to Sox5 mutants, Tbr1 mutants exhibit ectopic axon projections to the hypothalamus and cerebral peduncle. Together, our findings show that Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons.arealization | Auts2 | microarray

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Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

Bedogni¹,

Hodge

Elsen

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

297

336

View full text Add to dashboard Cite

show abstract

“…Interestingly, a recent microarray study revealed downregulation of ABBA mRNA in the brain of Emx2-knockout mice (Li et al, 2006). Emx2 is a homeodomain-containing transcription factor that is important in development and patterning of the neocortex (Cecchi, 2002).…”

Section: Abba Is a Key Regulator Of Glial Cell Morphologymentioning

confidence: 99%

ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension

Saarikangas

Hakanen

Mattila

et al. 2008

Journal of Cell Science

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Radial glia play key roles in neuronal migration, axon guidance, and neurogenesis during development of the central nervous system. However, the molecular mechanisms regulating growth and morphology of these extended cells are unknown. We show that ABBA, a novel member of the IRSp53-MIM protein family, is enriched in different types of radial glia. ABBA binds ATPactin monomers with high affinity and deforms PtdIns(4,5)P 2 -rich membranes in vitro through its WH2 and IM domains, respectively. In radial-glia-like C6-R cells, ABBA localises to the interface between the actin cytoskeleton and plasma membrane, and its depletion by RNAi led to defects in lamellipodial dynamics and process extension. Together, this study identifies ABBA as a novel regulator of actin and plasma membrane dynamics in radial glial cells, and provides evidence that membrane binding and deformation activity is critical for the cellular functions of IRSp53-MIM-ABBA family proteins. Supplementary material available online at

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“…In the developing mouse cortex, all teneurins are expressed in distinctive gradients and may be required for neocortical patterning (Li et al, 2006). Several reports point out their role in the development of visual pathways.…”

Section: Introductionmentioning

confidence: 99%

Caenorhabditis elegansTeneurin,ten-1, Is Required for Gonadal and Pharyngeal Basement Membrane Integrity and Acts Redundantly with Integrinina-1and Dystroglycandgn-1

Trzebiatowska

Topf

Sauder

et al. 2008

MBoC

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The Caenorhabditis elegans teneurin ortholog, ten-1, plays an important role in gonad and pharynx development. We found that lack of TEN-1 does not affect germline proliferation but leads to local basement membrane deficiency and early gonad disruption. Teneurin is expressed in the somatic precursor cells of the gonad that appear to be crucial for gonad epithelialization and basement membrane integrity. Ten-1 null mutants also arrest as L1 larvae with malformed pharynges and disorganized pharyngeal basement membranes. The pleiotropic phenotype of ten-1 mutant worms is similar to defects found in basement membrane receptor mutants ina-1 and dgn-1 as well as in the mutants of the extracellular matrix component laminin, epi-1. We show that the ten-1 mutation is synthetic lethal with mutations of genes encoding basement membrane components and receptors due to pharyngeal or hypodermal defects. This indicates that TEN-1 could act redundantly with integrin INA-1, dystroglycan DGN-1, and laminin EPI-1 in C. elegans development. Moreover, ten-1 deletion sensitizes worms to loss of nidogen nid-1 causing a pharynx unattached phenotype in ten-1;nid-1 double mutants. We conclude that TEN-1 is important for basement membrane maintenance and/or adhesion in particular organs and affects the function of somatic gonad precursor cells.

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Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning

Cited by 55 publications

References 47 publications

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension

Caenorhabditis elegansTeneurin,ten-1, Is Required for Gonadal and Pharyngeal Basement Membrane Integrity and Acts Redundantly with Integrinina-1and Dystroglycandgn-1

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