Potential targets for the treatment of ADHD using transcranial electrical current stimulation

Boetzel, Cindy; Herrmann, Christoph S.

doi:10.1016/bs.pbr.2021.01.011

Cited by 8 publications

(6 citation statements)

References 81 publications

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“…1 and Table S3). 17,21,23,24,31,44–116 Finally, 22 RCTs were included (Table S4). 13–16,117–134 Figure 2 illustrates the entire geometric distribution of the treatment arms.…”

Section: Resultsmentioning

confidence: 99%

Multiple comparison of different noninvasive brain stimulation and pharmacologic interventions in patients with methamphetamine use disorders: A network meta‐analysis of randomized controlled trials

Satogami

Liang

et al. 2022

Psychiatry Clin Neurosci

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Aim: In recent decades, the prevalence of amphetamine and methamphetamine use disorders has at least doubled in some regions/countries, with accompanying high risks of drug overdose-associated mortality. Noninvasive brain stimulation (NIBS) methods may be effective treatments. However, the comparative efficacy of the NIBS protocol for amphetamine/ methamphetamine use disorder (AUD/MUD) remains unknown to date. The aim of this network meta-analysis (NMA) was to compare the efficacy and acceptability of various NIBS methods/protocols for AUD/MUD management.Methods: A frequentist model-based NMA was conducted. We included randomized controlled trials (RCTs) that investigated the efficacy of NIBS and guideline-recommended pharmacologic treatments to reduce craving severity in patients with either AUD or MUD. Results: Twenty-two RCTs including 1888 participants met the eligibility criteria. Compared with the sham/placebo group (study = 19, subjects = 891), a combination of intermittent theta burst stimulation over the left dorsolateral prefrontal cortex (DLPFC) and continuous TBS over the left ventromedial prefrontal cortex (study = 1, subjects = 19) was associated with the largest decreases in craving severity [standardized mean difference (SMD) = À1.50; 95% confidence intervals (95%CIs) = À2.70 to À0.31]. Highfrequency repetitive transcranial magnetic stimulation over the left DLPFC was associated with the largest improvements in depression and quality of sleep (study = 3, subjects = 86) (SMD = À2.48; 95%CIs = À3.25 to À1.71 and SMD = À2.43; 95%CIs = À3.38 to À1.48, respectively).The drop-out rate of most investigated treatments did not significantly differ between groups. Conclusion:The combined TBS protocol over the prefrontal cortex was associated with the greatest improvement in craving severity. Since few studies were available for inclusion, additional large-scale randomized controlled trials are warranted.

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“…1 and Table S3). 17,21,23,24,31,44–116 Finally, 22 RCTs were included (Table S4). 13–16,117–134 Figure 2 illustrates the entire geometric distribution of the treatment arms.…”

Section: Resultsmentioning

confidence: 99%

Multiple comparison of different noninvasive brain stimulation and pharmacologic interventions in patients with methamphetamine use disorders: A network meta‐analysis of randomized controlled trials

Satogami

Liang

et al. 2022

Psychiatry Clin Neurosci

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“…While this mini-review primarily focuses on tDCS, it is important to note that NiBS encompasses other non-invasive procedures applied both in healthy individuals and in neuropsychiatric disorders. Transcranial Alternating Current Stimulation (tACS) and transcranial Random Noise Stimulation (tRNS) are among these methods, capable of non-invasively modulating brain oscillations (Antal and Herrmann, 2016 ; Boetzel and Herrmann, 2021 ). Exploring the application of these recent NiBS techniques to address the electroencephalography abnormalities observed in DS (Babiloni et al, 2010 ; Velikova et al, 2011 ; Hamburg et al, 2021 ) holds promise for more comprehensive therapeutic approaches.…”

Section: Concluding Remarks and Future Direction Of Researchmentioning

confidence: 99%

Transcranial Direct Current Stimulation in neurogenetic syndromes: new treatment perspectives for Down syndrome?

Faralli,

Fucà,

Lazzaro

et al. 2024

Front. Cell. Neurosci.

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This perspective review aims to explore the potential neurobiological mechanisms involved in the application of transcranial Direct Current Stimulation (tDCS) for Down syndrome (DS), the leading cause of genetically-based intellectual disability. The neural mechanisms underlying tDCS interventions in genetic disorders, typically characterized by cognitive deficits, are grounded in the concept of brain plasticity. We initially present the neurobiological and functional effects elicited by tDCS applications in enhancing neuroplasticity and in regulating the excitatory/inhibitory balance, both associated with cognitive improvement in the general population. The review begins with evidence on tDCS applications in five neurogenetic disorders, including Rett, Prader-Willi, Phelan-McDermid, and Neurofibromatosis 1 syndromes, as well as DS. Available evidence supports tDCS as a potential intervention tool and underscores the importance of advancing neurobiological research into the mechanisms of tDCS action in these conditions. We then discuss the potential of tDCS as a promising non-invasive strategy to mitigate deficits in plasticity and promote fine-tuning of the excitatory/inhibitory balance in DS, exploring implications for cognitive treatment perspectives in this population.

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“…Following this rationale, Dallmer-Zerbe et al (2020) tested the effects of tACS on adults with AD/HD. They reported that tACS resulted in a larger P300 and fewer behavioral errors in a visual detection task (Boetzel and Herrmann, 2021). Another promising alternating-current protocol comes from Berger et al (2021), in which a tRNS protocol targeting bilateral dlPFC improved working memory and reduced symptoms in children with AD/HD, even compared to the tDCS-dlPFC protocol, suggesting that the tRNS protocol is more effective than the commonly used protocol.…”

Section: Tes In Ad/hdmentioning

confidence: 99%

Remote neurocognitive interventions for attention-deficit/hyperactivity disorder – Opportunities and challenges

Zhang

Johnstone

Sauce

et al. 2023

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Potential targets for the treatment of ADHD using transcranial electrical current stimulation

Cited by 8 publications

References 81 publications

Multiple comparison of different noninvasive brain stimulation and pharmacologic interventions in patients with methamphetamine use disorders: A network meta‐analysis of randomized controlled trials

Multiple comparison of different noninvasive brain stimulation and pharmacologic interventions in patients with methamphetamine use disorders: A network meta‐analysis of randomized controlled trials

Transcranial Direct Current Stimulation in neurogenetic syndromes: new treatment perspectives for Down syndrome?

Remote neurocognitive interventions for attention-deficit/hyperactivity disorder – Opportunities and challenges

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