Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists

Blaschuk, Orest W.

doi:10.3389/fcell.2022.866200

Cited by 18 publications

(15 citation statements)

References 167 publications

(342 reference statements)

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“…Primary invasion and metastasis of PDAC is also corelated to increased expression of N-Cad that stimulates migration and thus helps in survival as well as proliferation of PDAC [58]. So, antagonists of N-Cad help in controlling this metastatic cancer by affecting cell survival, adhesion, proliferation and invasion processes, these antagonists are signi cantly studied in animal models [59]. These antagonists of N-Cad could be phytochemicals as previously reported in other studies [60].…”

Section: Resultsmentioning

confidence: 94%

Caffeic acid, a dietary polyphenol pre-sensitizes PDAC to chemotherapeutic drug

Gupta

Tak

Rathore

et al. 2023

Preprint

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Purpose: Resistance to chemotherapeutics is an eminent cause which leads for search of options that help in diminution of Pancreatic Ductal Adenocarcinoma (PDAC) by overcoming resistance issues. Caffeic acid (CFA), a polyphenol occurring in many dietary foods is known to show anti-diabetic and anticancer properties potential.Methods: To unveil effect of CFA on PDAC we carried out this research in PDAC cells, following which we checked combination effect of CFA and chemotherapeutics and pre-sensitization effects of CFA. Multitudinous web-based approaches were applied for identifying CFA targets in PDAC and then getting their interconnections.Results and conclusions: Subsequently, we manifested CFA affects by in-vitro analysis showing IC50 concentrations of 37.37µM and 15.06µM on Panc-1 and Mia-PaCa-2 respectively. Combination index of CFA with different drugs was explored that gave no significant results leading to further investigate pre-sensitizing effects. CFA pre-sensitization reduced IC50 concentration of doxorubicin in both PDAC cell lines which also triggered ROS generation determined by DCFH-DA assay. Gene expression analysis revealed that CFA acts differently on both cell lines and triggers distinct signalling to overcome resistance. Collectively, this study investigated role of CFA as PDAC therapeutics and explored mechanism in mitigating resistance of PDAC by sensitizing to chemotherapeutics.

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Section: Resultsmentioning

confidence: 94%

Caffeic acid, a dietary polyphenol pre-sensitizes PDAC to chemotherapeutic drug

Gupta

Tak

Rathore

et al. 2023

Preprint

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“…The importance of the study of E-cadherin is due to its influence on the adhesive properties of the cell, it takes an active part in other processes as well, including the cell cycle and proliferation [29]. Some authors confirm the relationship between the decrease in β-catenin expression and the poor prognosis of the tumor and its clinical and morphological parameters [30].…”

Section: с екція хх іmentioning

confidence: 99%

“…At this time, those clinical and morphological signs that were studied in relation to possible predictors of negative results of conservative treatment, need to determine the dynamics in the treatment process and require "trial therapy" [29]. In this sense, it is possible to predict the effectiveness of progestagen therapy even before it begins, based on the absence or extremely low expression of PGR and E-cadherin and high expression of β-catenin [30]. For women in late reproductive and perimenopausal age, surgical treatment will be considered in such cases.…”

Section: с екція хх іmentioning

confidence: 99%

Molecular Mechanisms of Resistance of Endometrial Hyperplasia to Progestagen Therapy

Khaskhachykh¹,

Потапов²,

Garagulia³

2023

GoS

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The problem of resistance of atypical endometrial hyperplasia (AGE) to traditionally accepted, pathogenetically justified therapy with various types of progestins remains unsolved today. In approximately 17-20% of cases, there is a recurrence or even progression to atypical hyperplasia of the endometrium, which requires the use of surgical methods of treatment. The aim of the study was to review the literature sources to clarify the reasons for the resistance of endometrial hyperplasia without atypia to hormone therapy with different types of progestins in women with different types of estrogen and progesterone receptor expression in combination with the expression of the intercellular adhesion molecules E-cadherin and β-catenin.

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“…N-cadherin antagonist ADH-1 is the synthetic cyclic peptide (also known as CHAVC and Exherin). The biological effects of ADH-1 on tumors have been extensively investigated in various preclinical animal models and clinical trials [ 198 ]. It was found that ADH-1 treatment significantly enhanced the anti-tumor effects of chemotherapy in melanoma [ 199 ].…”

Section: Potential Therapies For Emt In Copdmentioning

confidence: 99%

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

Zhu

Lin

et al. 2022

Respir Res

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Cigarette smoke is a complex aerosol containing a large number of compounds with a variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly increases the risk of a variety of diseases, including chronic obstructive pulmonary disease (COPD) and lung cancer. Epithelial–mesenchymal transition (EMT) is a unique biological process, that refers to epithelial cells losing their polarity and transforming into mobile mesenchymal cells, playing a crucial role in organ development, fibrosis, and cancer progression. Numerous recent studies have shown that EMT is an important pathophysiological process involved in airway fibrosis, airway remodeling, and malignant transformation of COPD. In this review, we summarized the effects of cigarette smoke on the development and progression of COPD and focus on the specific changes and underlying mechanisms of EMT in COPD induced by cigarette smoke. We spotlighted the signaling pathways involved in EMT induced by cigarette smoke and summarize the current research and treatment approaches for EMT in COPD, aiming to provide ideas for potential new treatment and research directions.

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Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists

Cited by 18 publications

References 167 publications

Caffeic acid, a dietary polyphenol pre-sensitizes PDAC to chemotherapeutic drug

Caffeic acid, a dietary polyphenol pre-sensitizes PDAC to chemotherapeutic drug

Molecular Mechanisms of Resistance of Endometrial Hyperplasia to Progestagen Therapy

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

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