Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer’s disease

Gomaa, Adel A.; Farghaly, Hanan A; Abdel-Wadood, Yasmin A.; Gomaa, Ghada A.

doi:10.1007/s00210-021-02154-7

Cited by 11 publications

(6 citation statements)

References 144 publications

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“…This protection was also associated with potent hypolipidemic and antihyperglycemic effects, which in turn, reduced hepatic, cardiac, and serum levels of TGs, CHOL, and FFAs. These data support the previous observations by others who have also demonstrated the hypoglycemic and hypolipidemic effects of AKBA and other extracts of B. serrata in animal models of T1DM and T2DM [ 34 , 35 ]. In addition, AKBA also reduced cardiac and hepatic levels of FFAs, CHOL, and TGs, and reduced serum levels of CHOL, TGs, and LDL-c while increasing serum levels of HDL-c in the control rats.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, treatment with B. serrata extracts of AKBA exhibits antidiabetic and wound-healing properties. Both can attenuate hepatic and pancreatic damage through hypoglycemic, antihyperlipidemia, antioxidant, and anti-inflammatory properties effects [ 34 , 35 , 36 , 37 ]. Interestingly, some previous studies have also shown the exceptional ability of AKBA to modulate AMPK activity in various tissue.…”

Section: Introductionmentioning

confidence: 99%

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The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK

et al. 2023

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This study examined the protective effect of 11-keto-β-boswellic acid (AKBA) against streptozotocin (STZ)-induced diabetic cardiomyopathy (DC) in rats and examined the possible mechanisms of action. Male rats were divided into 5 groups (n = 8/each): (1) control, AKBA (10 mg/kg, orally), STZ (65 mg/kg, i.p.), STZ + AKBA (10 mg/kg, orally), and STZ + AKBA + compound C (CC/an AMPK inhibitor, 0.2 mg/kg, i.p.). AKBA improved the structure and the systolic and diastolic functions of the left ventricles (LVs) of STZ rats. It also attenuated the increase in plasma glucose, plasma insulin, and serum and hepatic levels of triglycerides (TGs), cholesterol (CHOL), and free fatty acids (FFAs) in these diabetic rats. AKBA stimulated the ventricular activities of phosphofructokinase (PFK), pyruvate dehydrogenase (PDH), and acetyl CoA carboxylase (ACC); increased levels of malonyl CoA; and reduced levels of carnitine palmitoyltransferase I (CPT1), indicating improvement in glucose and FA oxidation. It also reduced levels of malondialdehyde (MDA); increased mitochondria efficiency and ATP production; stimulated mRNA, total, and nuclear levels of Nrf2; increased levels of glutathione (GSH), heme oxygenase (HO-1), superoxide dismutase (SOD), and catalase (CAT); but reduced the expression and nuclear translocation of NF-κB and levels of tumor-necrosis factor-α (TNF-α) and interleukin-6 (IL-6). These effects were concomitant with increased activities of AMPK in the LVs of the control and STZ-diabetic rats. Treatment with CC abolished all these protective effects of AKBA. In conclusion, AKBA protects against DC in rats, mainly by activating the AMPK-dependent control of insulin release, cardiac metabolism, and antioxidant and anti-inflammatory effects.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK

et al. 2023

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“…The active constituents in all the species are similar [ 13 ]. Many of the reported activities of Boswellia are due to the presence of boswellic acids [ 14 , 15 ]. Apart from boswellic acids, Boswellia is rich in volatile constituents and these volatile components are also reported for antitumor, anti-inflammatory, and antioxidant actions [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Methanolic Extract of Frankincense (Boswellia Sacra) on Testis Mediated through Suppression of Oxidative Stress and Apoptosis

et al. 2022

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Boswellia sacra oleo gum resin (Burseraceae) commonly known as frankincense is traditionally used in many countries for its beneficial effect on male fertility. This study explores its effect on the male reproductive system after a 60-day repeated administration at two different doses to rats (in vivo) and on human Leydig cells (in vitro). The methanolic extract of B. sacra was analyzed for the presence of various constituents by preliminary phytochemical analysis and gas chromatography-mass spectrometry (GC-MS) while quantitative analysis of boswellic acids was done by high-performance liquid chromatography (HPLC). Administration of B. sacra extract to rats elevated the serum testosterone levels with an associated reduction in serum levels of FSH and LH. An increase in the activity of antioxidant enzymes, superoxide dismutase and catalase, was seen. A dose-dependent increase in the sperm count and sperm motility was also observed. The in vivo results were supported by changes in the expression of the Bcl-2 gene and caspase-3 gene in human Leydig cells in vitro. The results of this study support the traditional use of B. sacra to increase male fertility.

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“…In addition, B. serrata extract was found to improve cognitive deficit in Alzheimer's Disease (AD). Both chemical-induced and transgenic models of AD were positively improved with BAs treatment (23,(98)(99)(100). The proposed mechanisms include the reduction of ROS, pro-inflammatory cytokines, tau phosphorylation, amyloid-β-induced apoptosis, and the antagonism of acetylcholinesterase (98,(100)(101)(102)(103).…”

Section: Preclinical Evidencementioning

confidence: 99%

From Preclinical to Clinical Evidence: Exploring the Multiple Perspectives and Healing Power of Boswellia Serrata Roxb. Ex Colebr

Biagi,

Sarill,

Collotta

et al. 2023

Pharm Adv

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Boswellia serrata Roxb. ex Colebr. is a species belonging to the Burseraceae family, typical of dry environments of the Indian region. The oil-gum-resin, obtained from the trunk and thick branches, is known in phytotherapy for the volatile fraction which contains up to 70% terpenes. The most important and characteristic constituents are represented by pentacyclic triterpenes, named boswellic acids. B. serrata is known for multiple beneficial effects, mainly correlated to anti-inflammatory activity. This review aims to provide a comprehensive overview on the activities and potential applications of B. serrata based on clinical and preclinical evidence. An up-to-date literature review of preclinical and clinical studies related to the applications of B. serrata preparations in different pathological conditions was conducted using the main databases of scientific literature. A body of evidence point out the role of B. serrata extracts and its active constituents in the treatment of several inflammatory diseases. In particular, clinical trials revealed its use as a topical remedy of skin diseases, such as eczema and psoriasis, and internally in the treatment of asthma, intestinal and osteoarticular inflammatory diseases. Preclinical findings highlighted the positive effects of B. serrata extracts in cardiovascular and neurodegenerative diseases, and in cancer. Finally, B. serrata finds application as a feed additive in veterinary use. Although some limitations must be overcome, such as poor bioavailability, evidence supports that B. serrata is a promising medicinal plant. Furthermore, the use of B. serrata appears to have a favorable toxicological profile, but caution may be necessary regarding potential botanical-drug interactions.

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Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer’s disease

Cited by 11 publications

References 144 publications

The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK

The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK

Beneficial Effect of Methanolic Extract of Frankincense (Boswellia Sacra) on Testis Mediated through Suppression of Oxidative Stress and Apoptosis

From Preclinical to Clinical Evidence: Exploring the Multiple Perspectives and Healing Power of Boswellia Serrata Roxb. Ex Colebr

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