Potential Therapeutic Targets of Quercetin in the Cutaneous Melanoma Model and Its Cellular Regulation Pathways: A Systematic Review

Salgado, Mariana Teixeira Santos Figueiredo; Silva, Estela Fernandes e; Nascimento, M.; Lopes, Alessandra Costa; Paiva, Luciana Souza de; Votto, Ana Paula de Souza

doi:10.1080/01635581.2023.2241698

Cited by 2 publications

(2 citation statements)

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“…In the study of Gao et al (2022) [ 94 ], a new steroid with the molecular formula C 24 H 34 O 4 isolated from leaves of A. altissima demonstrated an important antiproliferative effect on HepG2 cells, with an IC 50 = 4.03 μM, more effective than the antiproliferative drug sorafenib. To our knowledge, no studies reported any investigation of A. altissima leaf extract on MeWo cells, but published research showed that quercetin, a polyphenolic compound of flavonoid class, inhibits the signaling and expression of the c-Met receptor in wild-type melanoma MeWo [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

“…No hemolytic studies have been reported for A. altissima. In the study of Silva et al (2023) [89], the synthetic pure coumarin D, a chemical compound found in A. altissima bark being of interest for its antifungal properties, showed a low hemolytic effect (<5%), while several analogs of it determined even less hemolysis. However, the authors indicated that the results cannot exempt the extract from showing toxicity towards other types of cells in the human body.…”

Section: Hemolytic Activitymentioning

confidence: 99%

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In Vitro Screening of Ecotoxic and Cytotoxic Activities of Ailanthus altissima Leaf Extract against Target and Non-Target Plant and Animal Cells

Cocîrlea,

Simionescu,

Petrovici

et al. 2024

IJMS

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Ailanthus altissima, an invasive plant species, exhibits pharmacological properties, but also some allergic effects on humans. This study aimed to evaluate the potential toxicity of A. altissima leaves, using a complex approach towards different organisms. The ecotoxic impact of a crude extract was investigated on seeds germination and brine shrimp lethality. Cytotoxicity was studied in vitro using non-target (haemolysis, liposomal model, fibroblast), and target (cancer cells) assays. Leaf extract at 1000 µg/mL significantly inhibited wheat and tomato germination, while no significant effects were found on parsley germination. A slight stimulatory effect on wheat and tomato germination was found at 125 µg/mL. In a brine shrimp-test, the extract showed a low toxicity at 24 h post-exposure (LC50 = 951.04 ± 28.26 μg/mL), the toxic effects increasing with the exposure time and extract concentration. Leaf extract caused low hematotoxicity. The extract was biocompatible with human gingival fibroblasts. No anti-proliferative effect was found within the concentration range of 10–500 µg/mL on malignant melanoma (MeWo) and hepatocellular carcinoma (HepG2). In a liposomal model-test, the extract proved to possess low capability to alter the eukaryotic cell-mimicking membranes within the tested concentration range. Given the low to moderate toxicity on tested organisms/cells, the A. altissima autumn leaves may find useful applications.

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Section: Resultsmentioning

confidence: 99%

Section: Hemolytic Activitymentioning

confidence: 99%

In Vitro Screening of Ecotoxic and Cytotoxic Activities of Ailanthus altissima Leaf Extract against Target and Non-Target Plant and Animal Cells

Cocîrlea,

Simionescu,

Petrovici

et al. 2024

IJMS

View full text Add to dashboard Cite

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Phytocompounds and Nanoformulations for Anticancer Therapy: A Review

Bozzuto,

Calcabrini,

Colone

et al. 2024

Molecules

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Cancer is a complex disease that affects millions of people and remains a major public health problem worldwide. Conventional cancer treatments, including surgery, chemotherapy, immunotherapy, and radiotherapy, have limited achievements and multiple drawbacks, among which are healthy tissue damage and multidrug-resistant phenotype onset. Increasing evidence shows that many plants’ natural products, as well as their bioactive compounds, have promising anticancer activity and exhibit minimal toxicity compared to conventional anticancer drugs. However, their widespread use in cancer therapy is severely restricted by limitations in terms of their water solubility, absorption, lack of stability, bioavailability, and selective targeting. The use of nanoformulations for plants’ natural product transportation and delivery could be helpful in overcoming these limitations, thus enhancing their therapeutic efficacy and providing the basis for improved anticancer treatment strategies. The present review is aimed at providing an update on some phytocompounds (curcumin, resveratrol, quercetin, and cannabinoids, among others) and their main nanoformulations showing antitumor activities, both in vitro and in vivo, against such different human cancer types as breast and colorectal cancer, lymphomas, malignant melanoma, glioblastoma multiforme, and osteosarcoma. The intracellular pathways underlying phytocompound anticancer activity and the main advantages of nanoformulation employment are also examined. Finally, this review critically analyzes the research gaps and limitations causing the limited success of phytocompounds’ and nanoformulations’ clinical translation.

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Potential Therapeutic Targets of Quercetin in the Cutaneous Melanoma Model and Its Cellular Regulation Pathways: A Systematic Review

Cited by 2 publications

References 124 publications

In Vitro Screening of Ecotoxic and Cytotoxic Activities of Ailanthus altissima Leaf Extract against Target and Non-Target Plant and Animal Cells

In Vitro Screening of Ecotoxic and Cytotoxic Activities of Ailanthus altissima Leaf Extract against Target and Non-Target Plant and Animal Cells

Phytocompounds and Nanoformulations for Anticancer Therapy: A Review

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