Potential Therapeutic Use of Coenzyme Q10 in Diabetes Mellitus and Its Complications: an Algorithm of Scoping Clinical Review

Al‐Taie, Anmar; Victoria, Arueyingho Oritsetimeyin; Hafeez, Abdul

doi:10.1007/s42399-021-00819-1

Cited by 3 publications

(2 citation statements)

References 71 publications

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“…Supplementary medications and antioxidant pharmaceuticals are used for more than merely avoiding deficiencies and decreasing free radical generation. Viral infections are only one of the many indicators that vitamins and antioxidants may be sufficient [35].…”

Section: Discussionmentioning

confidence: 99%

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Antiviral Impact of Melatonin with Reference to Influenza Virus and Covid-19 Infection

Rai¹,

Rathore²

2021

Act Scie Canbio

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Melatonin has long been considered to play a crucial role in our interactions with viruses. Influenza, sometimes known as the flu, is an RNA virus-borne infectious illness to play a crucial role in our interactions with viruses. Influenza, sometimes known as the flu, is an RNA virus-borne infectious illness TNF-α, IL-6, and IFN-γ are inflammatory cytokines. IFN-γ inhibits the viral infection. Melatonin therapy dramatically reduces TNF-α, IL-6, and IFN-γ expression while increasing IL-10 and TGF-β production, according to this study. Melatonin promotes the synthesis of IL-10 by upregulating the expression of IL-27 in dendritic cells. Melatonin also decreases the levels of TNF-α in CD8 T cells in a considerable way. Compared to ribavirin alone, melatonin plus ribavirin co-treatment dramatically enhances the lifespan of virus-infected mice. Melatonin therapy decreases the production of inflammatory cytokines while increases the production of anti-inflammatory cytokines during influenza infection with a virus. Findings suggest that melatonin might be used as an adjuvant therapy with antiviral medications to treat influenza-induced pneumonia and COVID-19.

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Section: Discussionmentioning

confidence: 99%

“…Such knowledge on this subject is quickly expanding, and it is presumed that this will aid in the finding of suitable vitamins and antioxidants for use in pharmacotherapy. As a result, after the end of COVID-19 Pandemic and access to effective vaccinations and supplements will contribute to improved health and social well-being [35].…”

Section: Discussionmentioning

confidence: 99%

Antiviral Impact of Melatonin with Reference to Influenza Virus and Covid-19 Infection

Rai¹,

Rathore²

2021

Act Scie Canbio

View full text Add to dashboard Cite

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Coenzyme Q10 as a potential add-on treatment for patients suffering from painful diabetic neuropathy: results of a placebo-controlled randomized trial

Amini

Sajedi

Mirjalili

et al. 2022

Eur J Clin Pharmacol

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Diabetic Microvascular Complications and Proposed Interventions and Approaches of Management for Patient Care

Al‐Taie

Elseidy²,

Victoria

et al. 2021

Biomedical and Biotechnology Research Journal (BBRJ)

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Patients with diabetes mellitus are more likely to suffer microvascular complications, such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, which, if undiagnosed or untreated, may have a debilitating effect on patients' quality of life and pose a substantial financial strain on health-care providers. Glycemic regulation and diabetes length are the most powerful risk factors; nevertheless, other modifiable risk factors including hypertension, hyperlipidemia, and smoking, as well as unmodifiable risk factors, including age at onset of diabetes and genetic factors can all play a role. In addition to the involvement of potential risk factors, several links have been discovered between diabetic microvascular complications and one another, which seems to be significant associations for the development of these different microvascular complications. However, in order to help mitigate morbidity and mortality, considering the initiation and progression of all three complications as interconnected must be identified and managed at an early stage. Therefore, a variety of approaches to developing therapies to mitigate the negative effects of these complications are currently being studied in clinical trials which may contribute to potential long-term benefits in the management of different diabetic microvascular complications. This literature review summarizes the cellular and molecular pathways that lead to diabetic microvascular pathologies with emphasis on the clinical benefits of a variety of therapeutic approaches and insights into simple, comprehensive therapeutic interventions for clinical practice which could be optimal to reduce the risk and severity of different diabetic microvascular complications.

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Potential Therapeutic Use of Coenzyme Q10 in Diabetes Mellitus and Its Complications: an Algorithm of Scoping Clinical Review

Cited by 3 publications

References 71 publications

Antiviral Impact of Melatonin with Reference to Influenza Virus and Covid-19 Infection

Antiviral Impact of Melatonin with Reference to Influenza Virus and Covid-19 Infection

Coenzyme Q10 as a potential add-on treatment for patients suffering from painful diabetic neuropathy: results of a placebo-controlled randomized trial

Diabetic Microvascular Complications and Proposed Interventions and Approaches of Management for Patient Care

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