2024
DOI: 10.1002/jimd.12810
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Potential therapeutic uses of L‐citrulline beyond genetic urea cycle disorders

Marshall Summar

Abstract: L‐citrulline (referred to hereafter as citrulline), a non‐essential amino acid and an intermediate in the urea cycle, is widely recognized for its role in managing genetic urea cycle disorders (UCDs). Recent studies, however, suggest that citrulline's therapeutic potential extends beyond UCDs, particularly in conditions associated with nitric oxide (NO) deficiency, endothelial dysfunction, and oxidative stress. This review explores citrulline's emerging applications in sickle cell disease (SCD), post‐operative… Show more

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