Potential threat of human pathogenic orthopoxviruses to public health and control strategies

Zhang, Yongli; Zhou, Yuan; Pei, Rongjuan; Chen, Xinwen; Wang, Yun

doi:10.1016/j.jobb.2022.12.004

Cited by 9 publications

(2 citation statements)

References 77 publications

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“…These are the ACAM2000, a secondgeneration live Vaccinia virus vaccine, and JYNNEOS, an attenuated third-generation vaccine based on modified vaccinia Ankara (MVA). The ACAM2000 was initially developed to replace the Dryvax vaccine for mpox since the former utilized more current standards of quality control for vaccine production 23 . As a result, most of the US Strategic National Stockpile consists of the ACAM2000 vaccine 24 .…”

Section: Detection and Treatmentmentioning

confidence: 99%

A Brief Review of the Monkeypox Outbreak: Transmission, Presentation, and Developments in Treatment and Vaccines

Elahi¹,

Maddox²,

Khuram³

et al. 2023

J Immunological Sci

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The medical response to monkeypox(mpox) is a key demonstration of how COVID-19 remodeled the global response to viruses in the medical field. As a result of the 2019 pandemic, the 2022 mpox outbreak was met with mass production of vaccines, widely available PCR testing, and increased public health and research efforts. Easy access to vaccines such as the ACAM2000 and the JYNNEOS vaccines bolstered prevention while antivirals alleviated symptoms and shortened viral duration in at-risk patients. Various methods of detection have been developed for mpox over a short period with PCR currently being used in an attempt to isolate specific strains of the virus. In this brief review, we discuss its classical presentation, and detection and treatment strategies adapted to mitigate this public health risk.

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Section: Detection and Treatmentmentioning

confidence: 99%

A Brief Review of the Monkeypox Outbreak: Transmission, Presentation, and Developments in Treatment and Vaccines

Elahi¹,

Maddox²,

Khuram³

et al. 2023

J Immunological Sci

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“…While smallpox virus, also known as variola virus, caused millions of deaths worldwide, monkeypox virus, although less deadly than smallpox virus, can still cause severe illness in humans and has been identified as a potential emerging infectious disease. Orthopoxviruses remain a significant public health concern due to their potential for bioterrorism and the emergence of new and dangerous strains [4,5]. The Orthopoxvirus family encompasses some other closely related viruses such as vaccinia, horsepox, taterapox, cowpox, alaskapox, camelpox, raccoonpox, orthopox, and volepox etc.…”

Section: Introductionmentioning

confidence: 99%

In-silico formulation of a next-generation polyvalent vaccine against multiple strains of monkeypox virus and other related poxviruses

Moin,

Rani,

Patil

et al. 2024

PLoS ONE

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Mpox (formerly known as monkeypox) virus and some related poxviruses including smallpox virus pose a significant threat to public health, and effective prevention and treatment strategies are needed. This study utilized a reverse vaccinology approach to retrieve conserved epitopes for monkeypox virus and construct a vaccine that could provide cross-protection against related viruses with similar antigenic properties. The selected virulent proteins of monkeypox virus, MPXVgp165, and Virion core protein P4a, were subjected to epitope mapping for vaccine construction. Two vaccines were constructed using selected T cell epitopes and B cell epitopes with PADRE and human beta-defensins adjuvants conjugated in the vaccine sequence. Both constructs were found to be highly antigenic, non-allergenic, nontoxic, and soluble, suggesting their potential to generate an adequate immune response and be safe for humans. Vaccine construct 1 was selected for molecular dynamic simulation studies. The simulation studies revealed that the TLR8-vaccine complex was more stable than the TLR3-vaccine complex. The lower RMSD and RMSF values of the TLR8 bound vaccine compared to the TLR3 bound vaccine suggested better stability and consistency of hydrogen bonds. The Rg values of the vaccine chain bound to TLR8 indicated overall stability, whereas the vaccine chain bound to TLR3 showed deviations throughout the simulation. These results suggest that the constructed vaccine could be a potential preventive measure against monkeypox and related viruses however, further experimental validation is required to confirm these findings.

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Stability analysis of a fractional-order monkeypox epidemic model with quarantine and hospitalization

Musafir,

Suryanto,

Darti

et al. 2024

Journal of Biosafety and Biosecurity

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Potential threat of human pathogenic orthopoxviruses to public health and control strategies

Cited by 9 publications

References 77 publications

A Brief Review of the Monkeypox Outbreak: Transmission, Presentation, and Developments in Treatment and Vaccines

A Brief Review of the Monkeypox Outbreak: Transmission, Presentation, and Developments in Treatment and Vaccines

In-silico formulation of a next-generation polyvalent vaccine against multiple strains of monkeypox virus and other related poxviruses

Stability analysis of a fractional-order monkeypox epidemic model with quarantine and hospitalization

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