Aloe vera L. (Aloe barbadensis Miller) is a very common water deficit-resistant plant and has immense medicinal properties. It is a fleshy plant and belongs to the Liliaceae family. Aloe barbadensis has enormous medicinal value and according to historical records, has been in use in folk medicine and traditional medicine in different parts and regions of the world since ages. Aloe vera is used widely in Ayurvedacharya an Unani medicine. The plant is a rich source of potent medicinal phytocomponents each with pronounced medicinal properties. Primarily, the Aloe gel is considered as one of Mother Nature’s magic formulation for treating and curing various health ailments including skin diseases, hair fall, indigestion, inflammation and several others. Studies reveal that use of biofertilizers significantly improves the growth and development of Aloe plant. The quality and quantity of the constituents of the gel of Aloe is also reported to improve significantly with use of biofertilizers. Biofertilizers when used singly or in combinations are reported to influence the length, width, biomass and phytoconstituents of the leaves of the plant. Biofertilizers, which are environment friendly and more effective on Aloe, can thus be considered as better substitute of other fertilizers for boosting the qualitative and quantitative yield of the magical medicinal plant, Aloe barbadensis.