Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant

Chota, Alexander; George, Blassan P.; Abrahamse, Heidi

doi:10.3390/molecules25194435

Cited by 17 publications

(8 citation statements)

References 84 publications

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“…In particular, breast and lung cancer are treated with D. anomala extract’s anticancer capabilities. 31 Secoisolariciresinol diglucoside, a kind of phytoestrogen lignan found in Linum usitatissimum (flaxseed), is fermented in the large intestine to produce enterolactone and enterodiol. This intellectual metamorphosis has a positive impact on flaxseed’s anticancer properties.…”

Section: Plant Extracts In Breast Cancer Treatmentmentioning

confidence: 99%

“…Although numerous in vitro studies have demonstrated the potential of ginseng extract or its active components as effective anticancer agents in BC, it should be noted that the findings are limited to laboratory settings 31 These compounds have shown the ability to modulate signaling pathways associated with inflammation, oxidative stress, angiogenesis, metastasis, and the stem/progenitor-like properties of cancer cells. However, further research and clinical trials are necessary to establish the efficacy and safety of ginseng extract or its active components in the treatment of BC.…”

Section: Plant Extracts In Breast Cancer Treatmentmentioning

confidence: 99%

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Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

Azhari Rad,

Naghdi,

Majidi Jamalabadi

et al. 2024

Breast Cancer�(Auckl)

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Despite recent improvements in detecting and managing breast cancer (BC), it continues to be a major worldwide health concern that annually affects millions of people. Exploring the anti-BC potentials of natural compounds has received a lot of scientific attention due to their multi-target mode of action and good safety profiles because of these unmet needs. Drugs made from herbs are secure and have a lot fewer negative effects than those made from synthetic materials. Early stage patients benefit from breast-conserving surgery, but the risk of local recurrence remains, necessitating implanted scaffolds. These scaffolds provide residual cancer cell killing and tailored drug delivery. This review looks at plant extract–infused tissue engineering scaffolds, which provide a novel approach to treating BC. By offering patient individualized, safer treatments, these scaffolds could completely change how BC is treated.

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Section: Plant Extracts In Breast Cancer Treatmentmentioning

confidence: 99%

Section: Plant Extracts In Breast Cancer Treatmentmentioning

confidence: 99%

Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

Azhari Rad,

Naghdi,

Majidi Jamalabadi

et al. 2024

Breast Cancer�(Auckl)

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“…They evaluated these effects in vitro , specifically against MCF-7 breast cancer cells and NF54 parasitic strains [ 57 ]. Additionally, the study also investigated aqueous root extracts from D. anomala to explore their potential in reducing postprandial hyperglycaemia and modulating the activities of carbohydrate-metabolizing enzymes [ 58 , 59 ]. The pharmacological properties of D. anomala have been investigated for their potential in the treatment of various diseases.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Efficacy of Green Synthesized Nanoparticles in Photodynamic Therapy: A Therapeutic Approach

Zahra

Chota

Abrahamse

et al. 2023

IJMS

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Cancer is a complex and diverse disease characterized by the uncontrolled growth of abnormal cells in the body. It poses a significant global public health challenge and remains a leading cause of death. The rise in cancer cases and deaths is a significant worry, emphasizing the immediate need for increased awareness, prevention, and treatment measures. Photodynamic therapy (PDT) has emerged as a potential treatment for various types of cancer, including skin, lung, bladder, and oesophageal cancer. A key advantage of PDT is its ability to selectively target cancer cells while sparing normal cells. This is achieved by preferentially accumulating photosensitizing agents (PS) in cancer cells and precisely directing light activation to the tumour site. Consequently, PDT reduces the risk of harming surrounding healthy cells, which is a common drawback of conventional therapies such as chemotherapy and radiation therapy. The use of medicinal plants for therapeutic purposes has a long history dating back thousands of years and continues to be an integral part of healthcare in many cultures worldwide. Plant extracts and phytochemicals have demonstrated the ability to enhance the effectiveness of PDT by increasing the production of reactive oxygen species (ROS) and promoting apoptosis (cell death) in cancer cells. This natural approach capitalizes on the eco-friendly nature of plant-based photoactive compounds, offering valuable insights for future research. Nanotechnology has also played a pivotal role in medical advancements, particularly in the development of targeted drug delivery systems. Therefore, this review explores the potential of utilizing photosensitizing phytochemicals derived from medicinal plants as a viable source for PDT in the treatment of cancer. The integration of green photodynamic therapy with plant-based compounds holds promise for novel treatment alternatives for various chronic illnesses. By harnessing the scientific potential of plant-based compounds for PDT, we can pave the way for innovative and sustainable treatment strategies.

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“…Globally, cancer remains the main public health concern. Cancer is denoted by the continued growth and proliferation of cancerous cells [ 1 , 2 ]. According to the GLOBOCAN estimates of 2020 reported by the International Agency for Research on cancer, the incidence rate of cancer was estimated at 19.3 million cases excluding 18.1 million non-melanoma skin cancers, and 10 million cancer-related deaths excluding 9.9 million non-melanoma skin cancers occurred in 2020 [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death

2021

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Cancer is a global public health concern that is characterized by the uncontrolled growth of tumor cells. It is regarded as the subsequent cause of death after cardiovascular disease. The most common types of cancer include breast, colorectal, lung, and prostate. The risk factors attributed to the development of common types of cancer are tobacco smoking, excessive alcohol consumption, dietary factors, ultraviolet radiation (UV), and lack of physical activities. Two major cellular apoptotic pathways targeted in cancer therapies are intrinsic and extrinsic. These two pathways are regulated by different types of proteins, the multidomain pro-apoptotic proteins (Bak, Bax, and Bok), BH3-only pro-apoptotic proteins (Bid, Bim, Bad, Noxa, and Puma), and the anti-apoptotic proteins (Mcl-1, Bfl-1, Bcl-X L , Bcl-2, Bcl-w, and Bcl-B). Other significant molecules/factors that are known to execute cellular apoptotic pathways include bioactive compounds, and reactive oxygen species (ROS). Proteolytic caspases are known to play a vital role in the initiation of apoptotic activities in cancerous cells. Based on their functions, they are categorized into initiators and executioners. Nanotechnology has produced novel outcomes in modern medicine. The green synthesis of nanoparticles has demonstrated prospective improvements in cancer therapies in combination with the existing therapies including photodynamic therapy. This review aims at highlighting the association between pro-apoptotic and antiapoptotic proteins, and their significance in cancer therapy.

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Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant

Cited by 17 publications

References 84 publications

Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

Efficacy of Green Synthesized Nanoparticles in Photodynamic Therapy: A Therapeutic Approach

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death

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