Potential treatment of calciphylaxis with vitamin K<sub>2</sub>: Comment on the article by Jacobs‐Kosmin and DeHoratius

Levy, Robert J.

doi:10.1002/art.23107

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…Although there are several reports mentioning the potential of prostacyclin and vitamin K 2 as well as bisphosphonate as therapeutic options for the disease (29-31), the present case did not allow us to precisely assess the clinical benefit of individual agents. Rather, the current report may emphasize the pitfalls of managing patients with NS who are subjected to warfarinization.…”

Section: Discussionmentioning

confidence: 66%

“…Despite the accumulation of anecdotal or systemic studies disclosing the nature of calciphylaxis ( 1 , 2 , 4 , 13 - 17 , 27 ), we feel that the ability to accurately diagnose the disease in the early stage and awareness of the disease itself remain challenges that must still be overcome by physicians. Although there are several reports mentioning the potential of prostacyclin and vitamin K 2 as well as bisphosphonate as therapeutic options for the disease ( 29 - 31 ), the present case did not allow us to precisely assess the clinical benefit of individual agents. Rather, the current report may emphasize the pitfalls of managing patients with NS who are subjected to warfarinization.…”

Section: Discussionmentioning

confidence: 66%

See 1 more Smart Citation

Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis

et al. 2016

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Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis. There seemed to be several contributing factors, including a disturbance of the patient's mineral metabolism and the systemic use of glucocorticoids and warfarin. Various concerns regarding the diagnostic and therapeutic conundrums that were encountered in the present case are also discussed.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 66%

Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis

et al. 2016

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“…41 There has been literature on different treatment modalities like bisphosphonates, vitamin K, low-density lipoprotein apheresis, low-dose tissue plasminogen activator infusion, but these should be considered on an individual basis. [42][43][44][45] The data from a large nationwide registry in management of calciphylaxis are summarized in Table 5. 46 The wound healing based on case reports and case series in cohort studies using different strategies as discussed above are summarized in Table 6.…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis in a Patient on Home Hemodialysis

Adapa¹,

Naramala

Gayam

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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Calciphylaxis is a rare and severe complication characterized by calcification of arterioles and capillaries in the dermis and subcutaneous adipose tissue that leads to ischemia, necrosis, and painful skin lesions in patients with end-stage renal disease (ESRD). It is also known as calcific uremic arteriolopathy. Calciphylaxis occurs most commonly with the ESRD with skin ulceration as a predominant presenting feature. Calcium-phosphorus dysregulation in dialysis patients are traditionally considered as a risk factor for the development of calciphylaxis. The involvement of an integrated interdisciplinary and multifaceted approach is key to the success of the calciphylaxis treatment. We present a case of a 51-year-old female with ESRD on home hemodialysis who developed calciphylaxis, which was successfully managed with increasing dialysis prescription, diligent wound care, and sodium thiosulfate infusion. Management of calciphylaxis in a patient receiving home hemodialysis has never been reported as per the review of the literature. Calciphylaxis is a sporadic disease, frequently encountered in the patients undergoing hemodialysis and carries a very grave prognosis. Current treatment is rarely effective, so preventive strategies play an important role by modifying the risk factors that promote the development of calciphylaxis.

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“…Studies on the actions of STS have noted direct vascular calcification inhibition, reduction in oxidative stress, and vasodilatory properties [ 44 , 45 , 46 ]. Other therapeutic options include intralesional STS, hyperbaric oxygen [ 1 ], bisphosphonates [ 47 ], cinacalcet [ 48 , 49 ], tissue plasminogen activator [ 50 ], sterile maggot therapy [ 51 ], vitamin K supplementation [ 52 ], low-density lipoprotein apheresis [ 53 ], and kidney transplantation [ 54 ]. Case reports suggest a benefit from treating abnormalities of calcium and phosphorus [ 55 , 56 , 57 , 58 ] and elevated parathyroid hormone [ 49 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

A 71-Year-Old Female with Myocardial Infarction and Long-Standing Ulcers on the Thigh

Flammineis¹,

Mulvaney

Kraft

et al. 2017

Dermatopathology

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Calciphylaxis is most commonly encountered in patients with end-stage renal disease; however, it is increasingly observed in nonuremic patients as well. It is important to consider and diagnose nonuremic calciphylaxis early, as prompt treatment and mitigation of associated risk factors is essential to improve long-term outcomes for these patients. Here, we present the case of a 71-year-old woman with atrial fibrillation on warfarin, but without renal disease, who presented with two long-standing ulcers on her thigh and was diagnosed with the aid of biopsy with calciphylaxis. We review the existing literature on the subject and offer this case as a representative report of a clinicopathologic correlation for this disorder.

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Potential treatment of calciphylaxis with vitamin K₂: Comment on the article by Jacobs‐Kosmin and DeHoratius

Cited by 10 publications

References 18 publications

Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis

Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis

Calciphylaxis in a Patient on Home Hemodialysis

A 71-Year-Old Female with Myocardial Infarction and Long-Standing Ulcers on the Thigh

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Potential treatment of calciphylaxis with vitamin K2: Comment on the article by Jacobs‐Kosmin and DeHoratius

Cited by 10 publications

References 18 publications

Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis

Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis

Calciphylaxis in a Patient on Home Hemodialysis

A 71-Year-Old Female with Myocardial Infarction and Long-Standing Ulcers on the Thigh

Contact Info

Product

Resources

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Potential treatment of calciphylaxis with vitamin K₂: Comment on the article by Jacobs‐Kosmin and DeHoratius