2023
DOI: 10.3390/biom13030563
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Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms

Abstract: Neuroblastoma (NB) is an extracranial tumor of the peripheral nervous system arising from neural crest cells. It is the most common malignancy in infants and the most common extracranial solid tumor in children. The current treatment for high-risk NB involves chemotherapy and surgical resection followed by high-dose chemotherapy with autologous stem-cell rescue and radiation treatment. However, those with high-risk NB are susceptible to relapse and the long-term side effects of standard chemotherapy. Polypheno… Show more

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Cited by 4 publications
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“…To combat the drugs’ low bioavailability, decrease adverse reactions and metabolism, and increase targeting to the brain, several novel drug delivery methods of metformin and resveratrol have been studied. Since transport through the BBB depends on the lipid solubility of substances and phytochemicals, these methods involve lipid-designed drug delivery systems, nanotechnologies, and encapsulation methods [ 75 ].…”
Section: Clinical Considerations and Relevancementioning
confidence: 99%
“…To combat the drugs’ low bioavailability, decrease adverse reactions and metabolism, and increase targeting to the brain, several novel drug delivery methods of metformin and resveratrol have been studied. Since transport through the BBB depends on the lipid solubility of substances and phytochemicals, these methods involve lipid-designed drug delivery systems, nanotechnologies, and encapsulation methods [ 75 ].…”
Section: Clinical Considerations and Relevancementioning
confidence: 99%