Potential urinary biomarkers in preeclampsia: a narrative review

Avendanha, Renata Araujo; Campos, Guilherme Figueiredo Coelho; Branco, Beatriz Castello; Ishii, Nicolle Coimbra; Gomes, Luiz Henrique Nacife; de Castro, Ailton José; Leal, Caio Ribeiro Vieira; Simões e Silva, Ana Cristina

doi:10.1007/s11033-023-09053-5

Cited by 4 publications

(1 citation statement)

References 78 publications

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“…Likewise, it is important to remark that some authors argue that not only the placenta but also organs and cells of the body are of great relevance in the pathogenesis of EO-PE and LO-PE. For instance, some authors give a central role to different alterations affecting podocytes, located in the kidneys [82][83][84], whereas endothelial cells, the liver or even the pancreas have also been suggested to take part in the pathogenesis and development of preeclampsia [85]. Future works relating placental changes similar to those observed in our study with clinical or biological parameters associated with these structures will be of great importance to connect and understand the complex picture of early and late-onset preeclampsia.…”

Section: Discussionmentioning

confidence: 57%

Oxidative Stress, Lipid Peroxidation and Ferroptosis Are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia

Ortega,

Garcia-Puente,

Fraile-Martinez

et al. 2024

Antioxidants

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Preeclampsia, a serious and potentially life-threatening medical complication occurring during pregnancy, is characterized by hypertension and often accompanied by proteinuria and multiorgan dysfunction. It is classified into two subtypes based on the timing of diagnosis: early-onset (EO-PE) and late-onset preeclampsia (LO-PE). Despite being less severe and exhibiting distinct pathophysiological characteristics, LO-PE is more prevalent than EO-PE, although both conditions have a significant impact on placental health. Previous research indicates that different pathophysiological events within the placenta may contribute to the development of preeclampsia across multiple pathways. In our experimental study, we investigated markers of oxidative stress, ferroptosis, and lipid peroxidation pathways in placental tissue samples obtained from women with LO-PE (n = 68) compared to healthy control pregnant women (HC, n = 43). Through a comprehensive analysis, we observed an upregulation of specific molecules associated with these pathways, including NADPH oxidase 1 (NOX-1), NADPH oxidase 2 (NOX-2), transferrin receptor protein 1 (TFRC), arachidonate 5-lipoxygenase (ALOX-5), acyl-CoA synthetase long-chain family member 4 (ACSL-4), glutathione peroxidase 4 (GPX4) and malondialdehyde (MDA) in women with LO-PE. Furthermore, increased ferric tissue deposition (Fe3+) was observed in placenta samples stained with Perls’ Prussian blue. The assessment involved gene and protein expression analyses conducted through RT-qPCR experiments and immunohistochemistry assays. Our findings underscore the heightened activation of inflammatory pathways in LO-PE compared to HC, highlighting the pathological mechanisms underlying this pregnancy disorder.

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