Potential Usage of Liposome-Encapsulated Phosphor for in Vivo Imaging of Tissue Oxygenation

Lo, Leu‐Wei; Ho, Ja‐an Annie; Chang, Yen-Hsiung; Chang, Che‐Wei; Yang, Chung‐Shi

doi:10.4015/s101623720400030x

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Since 1965, when Bangham et al have discovered and described liposomes structures [1], new perspectives for drug delivery [2], bioimaging [3][4][5], cosmetics and food applications [6], chemical analysis [7] were opened. Liposomes (lipid vesicles) are colloidal spherical composites of lipid bilayers self-assembled in aqueous media.…”

Section: Introductionmentioning

confidence: 99%

Silica-coated liposomes loaded with quantum dots as labels for multiplex fluorescent immunoassay

Beloglazova¹,

Goryacheva²,

Speranskaya³

et al. 2015

Talanta

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In: TALANTA, 134, 120-125, 2015. To refer to or to cite this work, please use the citation to the published version:Beloglazova N., Goryacheva O., Speranskaya E., Aubert T., Shmelin P. , Kurbangaleev V., Goryacheva I.Y., De Saeger S. (2015). Silica-coated liposomes loaded with quantum dots as labels for multiplex fluorescent immunoassay. TALANTA, 134,[120][121][122][123][124][125] AbstractThis manuscript describes synthesis and followed application of silica-coated liposomes loaded with quantum dots as a perspective label for immunoaasay. The hollow spherical structure of liposomes makes them an attractive package material for encapsulation of multiple water-insoluble quantum dots and amplifying the analytical signal. Silica coverage ensures the stability of the loaded liposomes against fusion and internal leakage during storage, transporting, application and also provides groups for bioconugation. For the first time these nanostructures were employed for the sensitive multiplex immunochemical determination of two analytes. As a model system mycotoxins zearalenone and aflatoxin B1 were detected in cereals. For simplification of multiassay results' evaluation the silanized liposomed loaded with QDs of different colors were used. The IC 50 values for the simultaneous determination of zearalenone and aflatoxin B1 were 16.2 and 18 µg kg -1 for zearalenone and 2.2 and 2.6 µg kg -1 for aflatoxin B1 in wheat and maize, respectively. As confirmatory method, liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was used.

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