Potential Use of Biological Proteins for Liver Failure Therapy

Taguchi, Kazuaki; Yamasaki, Keishi; Seo, Hakaru; Otagiri, Masaki

doi:10.3390/pharmaceutics7030255

Cited by 9 publications

(4 citation statements)

References 119 publications

(122 reference statements)

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“…Liver failure is a heterogeneous and serious disease that is characterized by major harms, treatment difficulties, poor prognosis, and high mortality. 26,27 Liver failure can be categorized into acute liver failure, subacute liver failure, ACLF, and chronic liver failure; ACLF is the most common. 28 HBV-ACLF can lead to metabolic disorders and further impairment of multiple organ functions.…”

Section: Discussionmentioning

confidence: 99%

The NLRP3 inflammasome mediates liver failure by activating procaspase-1 and pro-IL-1 β and regulating downstream CD40-CD40L signaling

Jiang

2021

J Int Med Res

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Objectives In this prospective case–control study, we explored the regulatory roles of the NLRP3 inflammasome in hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Methods Thirty patients with HBV-ACLF, 30 patients with chronic hepatitis B, and 30 healthy individuals were enrolled. Real-time reverse transcription polymerase chain reaction was used to assess mRNA levels in peripheral blood mononuclear cells and serum protein levels were assessed by enzyme-linked immunosorbent assay. Results Serum levels of alanine aminotransferase, asparagine aminotransferase, total bilirubin, and direct bilirubin in patients with HBV-ACLF were increased. Transcript levels of NLRP3 and ASC and protein levels of interleukin (IL)-1β, IL-18, and sCD40L were elevated in patients with HBV-ACLF. Expression of the NLRP3 inflammasome signaling pathway components procaspase-1 and pro-IL-1β was elevated in patients with HBV-ACLF. Conclusions This prospective case-control study demonstrated that significant activation of the NLRP3 inflammasome occurs in patients with HBV-ACLF. The activated NLRP3 inflammasome mediated liver failure by stimulating procaspase-1 and pro-IL-1 β and regulating downstream CD40-CD40L signaling.

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Section: Discussionmentioning

confidence: 99%

The NLRP3 inflammasome mediates liver failure by activating procaspase-1 and pro-IL-1 β and regulating downstream CD40-CD40L signaling

Jiang

2021

J Int Med Res

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“…Studies performed to date dealing with this subject have shown that many tissues produce and locally release erythropoietin in response to hypoxic, biochemical and physical stress. Erythropoietin protects tissue from ischemia and reperfusion injury, it has antiapoptotic eff ect and promotes tissue regeneration [11][12][13][14]32 . We also used erythropoietin to predict whether the patient would be assigned to group 2 according to ISS score.…”

Section: Epo = Erythropoietinmentioning

confidence: 99%

“…As of today, many prognostic factors have been developed 5 . Erythropoietin, a glycoprotein predominantly synthesized in the kidneys, plays the central role in stimulation of erythropoiesis, but also has other purposes, such as cytoprotective, anti-apoptotic, anti-infl ammatory and antioxidant activity 11,12 . Studies have shown that the administration of erythropoietin before or after stressful event that led to cell ischemia protects cells from development of ischemic sequels 13 .…”

Section: Introductionmentioning

confidence: 99%

Erythropoietin in the Evaluation of Treatment Outcomes in Patients with Polytrauma

Arsenijević

Šijački

Marjanović

et al. 2017

ACC

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Polytrauma is a term describing patients with injuries involving multiple body regions that compromises function of the body and/or organ involved. The aim of the study was to evaluate the potential role of erythropoietin in predicting poorer outcome in trauma patients. This prospective study included 86 patients admitted to the Emergency Center of Serbia due to polytrauma assigned according to Injury Severity Score (ISS). The patients were further evaluated using the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores and erythropoietin levels. There was a significant difference among erythropoietin levels at admission, after 48 and 72 hours, and on day 7 of hospital stay, with significantly higher levels in patients with ISS values 49-75. Based on the results, ROC curves were used to identify cut-off levels to predict ISS score with critical clinical course. It was concluded that erythropoietin could be a good marker of injury severity. Further research has to be performed to determine the cut-off values of erythropoietin that are significant for injury severity.

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“…13% cationic lysine and arginine amino acids, and ca. 11% hydrophobic leucine, isoleucine, methionine, and valine), and gelatin-based matrices can in principle be used to deliver both small molecules and macromolecules. − In this study, we focus on a selection of low-molecular-weight drugs used in the clinic, as depicted in Figure .…”

Section: Introductionmentioning

confidence: 99%

Prediction of Drug Loading in the Gelatin Matrix Using Computational Methods

et al. 2020

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The delivery of drugs is a topic of intense research activity in both academia and industry with potential for positive economic, health, and societal impacts. The selection of the appropriate formulation (carrier and drug) with optimal delivery is a challenge investigated by researchers in academia and industry, in which millions of dollars are invested annually. Experiments involving different carriers and determination of their capacity for drug loading are very time-consuming and therefore expensive; consequently, approaches that employ computational/theoretical chemistry to speed have the potential to make hugely beneficial economic, environmental, and health impacts through savings in costs associated with chemicals (and their safe disposal) and time. Here, we report the use of computational tools (data mining of the available literature, principal component analysis, hierarchical clustering analysis, partial least squares regression, autocovariance calculations, molecular dynamics simulations, and molecular docking) to successfully predict drug loading into model drug delivery systems (gelatin nanospheres). We believe that this methodology has the potential to lead to significant change in drug formulation studies across the world.

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Potential Use of Biological Proteins for Liver Failure Therapy

Cited by 9 publications

References 119 publications

The NLRP3 inflammasome mediates liver failure by activating procaspase-1 and pro-IL-1 β and regulating downstream CD40-CD40L signaling

The NLRP3 inflammasome mediates liver failure by activating procaspase-1 and pro-IL-1 β and regulating downstream CD40-CD40L signaling

Erythropoietin in the Evaluation of Treatment Outcomes in Patients with Polytrauma

Prediction of Drug Loading in the Gelatin Matrix Using Computational Methods

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