Potential use of cidofovir, brincidofovir, and tecovirimat drugs in fighting monkeypox infection: recent trends and advancements

Rani, Isha; Joshi, Hemant; Sharma, Ujjawal; Kaur, Jagjit; Sood, Shivani; Ramniwas, Seema; Chauhan, Abhishek; Abdulabbas, Hadi Sajid; Tuli, Hardeep Singh

doi:10.1007/s00210-023-02769-y

Naunyn-Schmiedeberg's Arch Pharmacol

2023

DOI: 10.1007/s00210-023-02769-y

|View full text |Cite

Potential use of cidofovir, brincidofovir, and tecovirimat drugs in fighting monkeypox infection: recent trends and advancements

Isha Rani,

Hemant Joshi,

Ujjawal Sharma

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Human monkeypox virus: Epidemiologic review and research progress in diagnosis and treatment

Sun,

Nie,

Tian

et al. 2024

Journal of Clinical Virology

View full text Add to dashboard Cite

Human monkeypox virus: Epidemiologic review and research progress in diagnosis and treatment

Sun,

Nie,

Tian

et al. 2024

Journal of Clinical Virology

View full text Add to dashboard Cite

Unveiling the Global Surge of Mpox (Monkeypox): A comprehensive review of current evidence

Duarte,

Adesola,

Priyadarsini

et al. 2024

The Microbe

View full text Add to dashboard Cite

Evolutionary Analysis and Antiviral Drug Prediction of Mpox Virus

Lian,

Yang,

Qiu

et al. 2024

Microorganisms

View full text Add to dashboard Cite

The resurgence of mpox virus (MPXV) poses a significant challenge to global public health. Currently, there is a limited understanding of the evolutionary details of MPXV during its epidemics, and no specific drugs have been developed for it. Herein, analysis of mutations and positive selection sites (PSSs) within the MPXV genomes revealed 799 mutations and 40 PSSs. Visualization analysis indicated that these mutations and PSSs may affect protein structure. Additionally, a protein–protein interaction (PPI) network between human and MPXV was established, identifying 346 MPXV-interacting human proteins (MIHPs). An interaction network involving MIHPs and other viruses confirmed that these proteins can interact with various viruses that infect humans. Functional analysis of MIHPs suggested their enrichment in host immunity pathways. Lastly, two drugs targeting MIHPs and four compounds targeting MPXV proteins were screened as candidate antivirals against MPXV. These findings not only deepen our understanding of MPXV evolution but also aid in the development of anti-MPXV drugs.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Potential use of cidofovir, brincidofovir, and tecovirimat drugs in fighting monkeypox infection: recent trends and advancements

Cited by 3 publications

References 95 publications

Human monkeypox virus: Epidemiologic review and research progress in diagnosis and treatment

Human monkeypox virus: Epidemiologic review and research progress in diagnosis and treatment

Unveiling the Global Surge of Mpox (Monkeypox): A comprehensive review of current evidence

Evolutionary Analysis and Antiviral Drug Prediction of Mpox Virus

Contact Info

Product

Resources

About