Potential use of copper surfaces to reduce survival of epidemic meticillin-resistant Staphylococcus aureus in the healthcare environment

Noyce, J.O.; Michels, Harold T.; Keevil, C. W.

doi:10.1016/j.jhin.2005.12.008

Cited by 342 publications

(259 citation statements)

References 28 publications

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“…13 S. epidermidis 35984 is an intercellular adhesion positive strain (slime forming) and is a strong biofilm former. 14 Additionally, Pseudomonas aeruginosa PAO1 was selected as a representative Gram negative pathogen and is a well-categorized biofilm forming strain.…”

Section: Bacterial Strains and Growth Mediamentioning

confidence: 99%

Comparing PMMA and calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites

McConoughey

Howlin

Wiseman

et al. 2014

J. Biomed. Mater. Res.

108

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Antibiotic-loaded bone cement is a primary option for treatment of orthopedic infections. Poly(methyl methacrylate) (PMMA) is a widely used cement that, when loaded with antibiotics in spacer or bead form, has been shown to reduce infection rates. However, PMMA is not resorbable and requires a second surgery for removal, while also acting as a potential foreign body for bacterial colonization. Alternatively, resorbable bone cements, such as calcium sulfate, have been proposed and present the advantage of being completely reabsorbed. It is unknown whether the antibiotic elution characteristics of absorbable bone cements are similar to PMMA. This study (1) characterized antibiotic elution from synthetic, highly purified calcium sulfate cement beads of varying sizes against pathogenic bacteria both in liquid culture and seeded on agar plates, (2) tested calcium sulfate beads against PMMA beads loaded with the same antibiotics, and (3) analyzed the structural differences between how PMMA and calcium sulfate bind to antibiotics. In every assay, the calcium sulfate beads performed as well as, or better than, the PMMA beads in inhibition of bacterial growth and elution of vancomycin in vitro with complete elution observed from calcium sulfate within three days. These data suggest that calcium sulfate, functions, as well as PMMA in the patient setting for infection control.

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Section: Bacterial Strains and Growth Mediamentioning

confidence: 99%

Comparing PMMA and calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites

McConoughey

Howlin

Wiseman

et al. 2014

J. Biomed. Mater. Res.

108

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show abstract

“…1) It has been reported that copper surface can effectively eliminate Methicillinresistant Staphylococcus aureus (MRSA), Influenza A (H1N1) and Escherichia coli-DH5 (E. coli) within a few hours, [2][3][4][5][6][7][8][9] so copper surface can be ideal to be applied in a hospital environment to decrease the chance of transmission of bacteria. The surface of copper metal can be thermally passivated to reflect light and present various color observed by human eyes for decorative purposes 10,11) and interior design.…”

Section: Introductionmentioning

confidence: 99%

Some Aspects on the Discoloration and Antimicrobial Property of a Thermally Passivated Copper Surface in a Highly Humid Environment

et al. 2011

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“…Appreciation of its efficacy probably goes back for several millennia, and quite a few studies have succeeded in demonstrating it more or less quantitatively [7][8][9][10]. In a frequently-cited paper, Salgado et al went as far as asserting that copper surfaces reduce the rate of HAI [11]; the critique of this study [12], which effectively negates its conclusions, is unfortunately much less cited.…”

Section: Introductionmentioning

confidence: 94%

Disastrous performance of NanoCote/Aqua Based antimicrobial paint in a hospital setting

Ramsden¹,

Reid²,

Whatley³

et al. 2016

JBPC

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Attempts are being made to incorporate copper into clear varnish in order to coat environmental surfaces in hospitals with the long-term goal of reducing healthcare-acquired infections (HAI). The performance of a nanocopper-containing polyacrylic emulsion, NanoCote HD-WR, on bedrails, footboards, control panels, tables and lockers was evaluated. The paint was applied in four coats using conventional spraying technology according to the manufacturer's instructions to give a total thickness of c. 30 µm. After overnight curing the "clear" coat appeared rough, with uneven mottling, and remained clearly visible on all surfaces to which it had been applied. The coating demonstrated an unpleasant rubbery feel, engendering complaints from patients. Even the merest contact with water, such as light touching with a damp cloth, caused immediate blanching of the coating and the surface became extremely slippery. Contact with a lightly soiled cloth caused irreversible discoloration of the coating. The physical properties of this coating render it unacceptable for application in hospitals.

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Potential use of copper surfaces to reduce survival of epidemic meticillin-resistant Staphylococcus aureus in the healthcare environment

Cited by 342 publications

References 28 publications

Comparing PMMA and calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites

Comparing PMMA and calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites

Some Aspects on the Discoloration and Antimicrobial Property of a Thermally Passivated Copper Surface in a Highly Humid Environment

Disastrous performance of NanoCote/Aqua Based antimicrobial paint in a hospital setting

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