Potential use of durian fruit (Durio zibenthinus Linn) as an adjunct to treat infertility in polycystic ovarian syndrome

Ansari, Reshma Mohamed

doi:10.1016/s2095-4964(16)60240-6

Cited by 24 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1,2] The disease is characterized by ovulation disorders, androgen excess, and polycystic ovarian morphology. [2,3] Moreover, PCOS is a primary risk factor for adverse pregnancy outcomes. [4,5] A meta-analysis conducted by Kjerulff et al [6] indicated that pregnancy in PCOS patients was associated with increased risk of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, preterm delivery, and small-for-gestational-age (SGA); however, there was no significant impact on the risk of cesarean delivery, operative vaginal delivery, and large-for-gestational age (LGA).…”

Section: Introductionmentioning

confidence: 99%

Association between polycystic ovary syndrome and the risk of pregnancy complications

Chen²,

Rao³

et al. 2016

Medicine

211

203

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Association between polycystic ovary syndrome and the risk of pregnancy complications

Chen²,

Rao³

et al. 2016

Medicine

211

203

View full text Add to dashboard Cite

show abstract

“…It is reported that durian has anti-oxidant (Ang, 2018), anti-cancer, anti-cardiovascular, anti-diabetic Siburian et al, 2019) and anti-obesity properties (Leontowicz et al, 2008), and can improve digestion, cure insomnia, lower the blood pressure and relieve the symptoms of depression, anxiety, and stress disorders (Kumar et al, 2005;Haruenkit et al, 2007). Previous studies have also reported the potential use of durian fruit pulp as fertility enhancing agent and studies were conducted to find out its effectiveness to treat infertility in PCOS (polycystic ovarian syndrome) (Ansari, 2016). Although the fruit is effective against various components of metabolic syndrome, specific studies of the mechanism of ovulation and menstrual disturbances need to be conducted.…”

Section: Introductionmentioning

confidence: 99%

GC-MS Analysis of Phytochemical Constituents in Methanol Extract of Wood Bark from Durio Zibethinus Murr

2019

International Journal of Medicinal Plants and Natural Products

View full text Add to dashboard Cite

Durio zibethinus Murr. (Durian), a medicinally important plant belongs to the family Bombacaceae. Traditionally the decoctions of the leaf and root have believed to show antipyretic effect and can also be used as a febrifuge and anti-malarial agent. In the present study, the preliminary phytochemical screening of secondary metabolites in the wood bark of Durio zibethinus was investigated using standard methods. The methanol extract of the wood bark was fractionated into four combined fractions (F1-F4) and the bioactive compounds in the fractions were evaluated using Gas Chromatography-Mass Spectrometry. Phytochemical screening on this crude extract revealed the presence of phenols, alkaloids, steroids, tannins, terpenes, saponins and flavonoids. Gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of 2, 6, 5 and 4 compounds in fractions 1-4 respectively. The major chemical constituents identified are (Z)-9-Octadecenoic acid (Oleic Acid) (91.36 %), (E)-9-Octadecenoic acid (Elaidic Acid) (56.10 %), (Z)-6-Octadecenoic acid (Petroselinic acid) (41.19 %) and (E)-9-Octadecenoic acid (Elaidic Acid) (42.20 %) in fractions 1-4 respectively. The presence of these major constituents in the plant extract provides the scientific evidences for its biological and therapeutic properties related to health. Thus this research was aimed to investigate the secondary metabolites present in the wood bark of Durio zibethinus Murr that could have medicinal values and application in industries, as well as, to identify the phytoconstituents by using GC-MS analysis.

show abstract

“…In addition, durian plant is also used traditionally to treat diseases such as fever, jaundice and infertility (Ansari 2016;Sah et al 2014). However, despite of its nutraceutical and medicinal values, durian is believed to be a 'heaty' food (Ariff & Beng 2006).…”

Section: Introductionmentioning

confidence: 99%

Effects of Durian Fruit on Blood Pressure of Spontaneously Hypertensive Rats

Jasamai¹,

Samsudin

Azmi³

et al. 2018

JSM

View full text Add to dashboard Cite

Durian or scientifically known as Durio zibethinus is one of the most well-known seasonal fruits in the Southeast Asia region. However, its safe consumption in individuals with hypertension is still controversial. This study was conducted to investigate the effect of durian on blood pressure of spontaneously hypertensive rat model. Four groups of rats (n=5) were fed with either a low dose durian (26 g/kg), a high dose durian (52 g/kg), sugar solution (8 mL/kg) which has similar sugar composition in the durian as placebo control, and distilled water as vehicle control (8 mL/kg) for 14 days. The durian doses for rats were obtained by converting from human doses. Baseline reading of blood pressure and heart rate were recorded before the first oral administration of durian. The blood pressure and heart rate were also measured 1 h after the durian oral administration on day 1, 3, 7 and 14 of the experiment. In conclusion, durian fruit possessed an acute effect on the blood pressure of hypertensive rats but heart rate was unaffected. High dose administration of durian led to significant elevation of blood pressure after 1 h of consumption. Meanwhile, low dose of durian (26 g/kg) caused an insignificant reduction in systolic and diastolic blood pressure. Tolerance to the durian fruit was observed after three to seven days of the oral administration and low dose consumption of durian fruit was safe in the hypertensive rat.

show abstract

Potential use of durian fruit (Durio zibenthinus Linn) as an adjunct to treat infertility in polycystic ovarian syndrome

Cited by 24 publications

References 36 publications

Association between polycystic ovary syndrome and the risk of pregnancy complications

Association between polycystic ovary syndrome and the risk of pregnancy complications

GC-MS Analysis of Phytochemical Constituents in Methanol Extract of Wood Bark from Durio Zibethinus Murr

Effects of Durian Fruit on Blood Pressure of Spontaneously Hypertensive Rats

Contact Info

Product

Resources

About