Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers

Bailly, Christian

doi:10.1016/j.intimp.2019.105967

Cited by 47 publications

(21 citation statements)

References 84 publications

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“…Currently, coalition therapy combining surgery with chemotherapy, radiotherapy or immunotherapy is the main option in the clinic, however, PDAC is characterized by an extraordinary resistance to chemo- and radiotherapy as well as to molecularly targeted therapy and immunotherapy [ 9 – 17 ]. Worse still, the nonspecific damage caused by radiotherapy as well as chemotherapeutic agents’ toxicity-related side effects further reduce patients’ life quality [ 18 – 30 ]. Besides, for most patients, especially those in developing countries, immunotherapy or chemotherapy is simply not available or not affordable [ 31 – 38 ].…”

Section: Introductionmentioning

confidence: 99%

Topically applicated curcumin/gelatin-blended nanofibrous mat inhibits pancreatic adenocarcinoma by increasing ROS production and endoplasmic reticulum stress mediated apoptosis

et al. 2020

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Background Pancreatic adenocarcinoma (PDAC) is one of the most fatal malignancies. Surgical resection supplemented by chemotherapy remains the major therapeutic regimen, but with unavoidable resistance and systemic toxic reaction. Curcumin is a known safe natural compound that can effectively eliminate pancreatic adenocarcinoma cells in vitro, making it a promising candidate for substitution in subsequent chemotherapy. However, due to its extremely low bioavailability caused by its insolubility and circular elimination, curcumin had an unexpectedly modest therapeutic effect in clinical trials. Results Here, we electrospun curcumin/gelatin-blended nanofibrous mat to largely improve curcumin’s bioavailability by local controlled-release. With characterization by scanning electron microscopy, fluorescence microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and high-performance liquid chromatography, it was revealed that curcumin was uniformly dispersed in the fiber of the mats with nanoscopic dimensions and could be continuously released into the surrounding medium for days. The cancer inhibitory effects of nano-curcumin and underlying mechanisms were further explored by assays using pancreatic adenocarcinoma cell and experiments using xenograft model. The results showed the released nano-curcumin could effectively inhibit pancreatic adenocarcinoma cell proliferation not only in vitro, but more importantly in vivo. This cytotoxic effect of nano-curcumin against pancreatic adenocarcinoma was achieved through provoking the production of intracellular reactive oxygen species and activating endoplasmic reticulum stress, which leads to enhanced cell apoptosis via decreased phosphorylation of signal transducer and activator of transcription 3. Conclusions Clinically, curcumin/gelatin-blended nanofibrous mat could be a promising, secure, efficient and affordable substitutional agent for the elimination of residual cancer cells after tumor resection. Moreover, our strategy to obtain curcumin released from nanofibrous mat may provide a universally applicable approach for the study of the therapeutic effects and molecular mechanisms of other potential medicines with low bioavailability.

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Section: Introductionmentioning

confidence: 99%

Topically applicated curcumin/gelatin-blended nanofibrous mat inhibits pancreatic adenocarcinoma by increasing ROS production and endoplasmic reticulum stress mediated apoptosis

et al. 2020

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“…Edaravone is currently a commonly used ACI treatment drug in clinic. It has an Contrast Media & Molecular Imaging antioxidant effect [16] and can improve the neurological function of ACI patients [17]. Butylphthalide can reduce brain tissue damage due to its effect on oxidative stress [18], so it is also used in the treatment of ACI patients.…”

Section: Discussionmentioning

confidence: 99%

Fuzzy C-Means Clustering Algorithm-Based Magnetic Resonance Imaging Image Segmentation for Analyzing the Effect of Edaravone on the Vascular Endothelial Function in Patients with Acute Cerebral Infarction

Yin

Chang

Wang

et al. 2021

Contrast Media & Molecular Imaging

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This paper aimed to discuss the denoising ability of magnetic resonance imaging (MRI) images based on fuzzy C-means clustering (FCM) algorithm and the influence of Butylphthalide combined with Edaravone treatment on nerve function and vascular endothelial function in patients with acute cerebral infarction (ACI). Based on FCM algorithm, Markov Random Field (MRF) model algorithm was introduced to obtain a novel algorithm (NFCM), which was compared with FCM and MRF algorithm in terms of misclassification rate (MCR) and difference of Kappa index (KI). 90 patients with ACI diagnosed in hospital from December 2018 to December 2019 were selected as subjects, who were divided into combined treatment group (conventional treatment + Edaravone + Butylphthalide) and Edaravone group (conventional treatment + Edaravone) randomly, each consisting of 45 cases. The National Institutes of Health Stroke Scale (NIHSS) score and endothelial function index level such as plasma nitric oxide (NO), human endothelin-1 (ET-1), and vascular endothelial cell growth factor (VEGF) were compared before and after treatment between the two groups. The results showed that the MCR of NFCM was evidently inferior to FCM and MRF, and the KI was notably higher relative to the other two algorithms. After treatment, the NIHSS score of the combined treatment group was (9.09 ± 1.86) points and that of Edaravone group was (14.97 ± 3.44) points, with evident difference between the two groups ( P < 0.05 ). After treatment, the NO of the combined treatment was (54.63 ± 4.85), and that of Edaravone group was (41.54 ± 5.27), which was considerably different ( P < 0.01 ), and the VEGF and ET-1 of combined treatment group were greatly inferior to Edaravone group ( P < 0.01 ). It was revealed that the novel algorithm based on FCM can obtain more favorable quality and segmentation accuracy of MRI images. Moreover, Butylphthalide combined with Edaravone treatment can effectively improve nerve function, vascular endothelial function, and short-term prognosis in ACI, which was safe and worthy of clinical adoption.

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“…This antioxidant has been associated with a delay in the clinical onset of the disease (Table 1) in transgenic mice that express mutant copies of the gene encoding SOD1 (an animal model of ALS) (Gurney et al, 1996). Measurements of the erythrocyte activity of the three main radical scavenging enzymes (SOD1, CAT, and GPx) indicated that vitamin E supplementation (300-3000 U/day) in 14 ALS patients did not affect the activity of the Gurney et al, 1996;Desnuelle et al, 2001;Ascherio et al, 2005;Veldink et al, 2007; Ikeda and Iwasaki, 2015;Banno et al, 2005;Yoshino and Kimura, 2006;Miyamoto et al, 2013;Abe et al, 2014;Bailly, 2019 three enzymes (Przedborski et al, 1996). One study showed an accumulation of vitamin E in the spinal cord and increased MDA levels over the lifetime of the mouse compared to non-transgenic mice (Hall et al, 1998).…”

Section: Vitamin Ementioning

confidence: 99%

“…Edaravone eliminates lipid peroxides and hydroxyl radicals during cerebral ischemia, protects nerve cells within or around the ischemic region from free radical damage (Abe et al, 2014), ameliorate OS and suppress degeneration of spinal motor neurons (Ikeda and Iwasaki, 2015). It is attributed anti-inflammatory (Bailly, 2019) and protective effects in neurons, microglia, astrocytes and oligodendrocytes (Banno et al, 2005;Miyamoto et al, 2013) (Table 1).…”

Section: Edaravonementioning

confidence: 99%

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

et al. 2020

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD +) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS.

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Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers

Cited by 47 publications

References 84 publications

Topically applicated curcumin/gelatin-blended nanofibrous mat inhibits pancreatic adenocarcinoma by increasing ROS production and endoplasmic reticulum stress mediated apoptosis

Topically applicated curcumin/gelatin-blended nanofibrous mat inhibits pancreatic adenocarcinoma by increasing ROS production and endoplasmic reticulum stress mediated apoptosis

Fuzzy C-Means Clustering Algorithm-Based Magnetic Resonance Imaging Image Segmentation for Analyzing the Effect of Edaravone on the Vascular Endothelial Function in Patients with Acute Cerebral Infarction

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

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