Potential Use of Essential Oil Isolated from<i>Cleistocalyx operculatus</i>Leaves as a Topical Dermatological Agent for Treatment of Burn Wound

Tran, Gia-Buu; Le, Nghia-Thu Tram; Sao, Đàm

doi:10.1155/2018/2730169

Cited by 10 publications

(6 citation statements)

References 20 publications

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“…C. operculatus essential oil also exhibited antibacterial activity against S. aureus (7.17 ± 0.12 mm) whereas they had no activity against Pseudomonas aeruginosa [11]. Thus, our data confirmed the biological effect of ethanolic extract and fractions from three different solvents of C. operculatus leaves.…”

Section: Antibacterial Activity Of C Operculatus Crude Extract and Se...supporting

confidence: 79%

“…The essential oil from C. operculatus leaves (CLO) showed the antibacterial effect against S. aureus and supportive effect on burn wound healing. Treatment of this CLO fully recovered second-degree burn wound in mice after 20 days, whereas saline treated burn wound formed uneven epidermal layer with necrotic ulcer [11]. In our previous study, both aqueous and ethanolic extracts of C. operculatus leaves collected in Quang Nam could inhibit the growth of Gram-positive bacteria S. aureus and Listeria monocytogenes but not with Gram-negative E.coli or Salmonella sp [12].…”

Section: Introductionmentioning

confidence: 92%

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In-vitro antibacterial activity of the fractions from Cleistocalyx operculatus (Roxb.) Merr. et Perry against Staphylococcus aureus

Bich

Thu

Tran³

et al. 2023

UD-JST

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The prevalence of Gram-positive Staphylococcus aureus in infectious diseases is increasing in Vietnam for recent years. Therefore, novel class of antibiotic or active compounds is indispensable to treat this common worldwide pathogen. In the present study, we investigated the antibacterial activities of Cleistocalyx operculatus (Roxb.) Merr. et Perry leaves collected in Quang Nam. The results showed that ethanolic crude extract and three fractions partitioned in different polar solvents suppressed Staphylococcus aureus ATCC 6538. The ethyl acetate and n-hexan fractions exhibited a significant inhibitory effect, with minimum inhibitory concentrations (MIC) values of 0.1 mg/ml and 0.2 mg/ml, respectively. And flavonoids was possibly the active substances responsible for the antimicrobial activity of this medical plant. These initial findings are the premise of further studies for the treatment of infection. It also provides the scientific evidences for the traditional utilization of Cleistocalyx operculatus (Roxb.) Merr. et Perry leaves.

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Section: Antibacterial Activity Of C Operculatus Crude Extract and Se...supporting

confidence: 79%

Section: Introductionmentioning

confidence: 92%

In-vitro antibacterial activity of the fractions from Cleistocalyx operculatus (Roxb.) Merr. et Perry against Staphylococcus aureus

Bich

Thu

Tran³

et al. 2023

UD-JST

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“…In particular, Tran Gia Buu et al ( 2018) reported the antibacterial and anti-inflammatory properties of C. operculatus leaf essential oil. Particularly, the essential oil also had a supportive effect on the burn wound healing process, with a contraction rate of 100%, obviously higher than that of tamanu-oil-treated mice (79%) and control mice (71%) after 20 days of application [26]. In summary, essential oils extracted from C. operculatus had notable antimicrobial and anti-inflammatory effects, and could be exploited as topical dermatological agents.…”

Section: Modeling the Structures Of α-Glucosidase Complexes With Main...mentioning

confidence: 88%

Chemical Composition, Anti-α-Glucosidase Activity, and Molecular Modelling Studies of Cleistocalyx operculatus Essential Oil

Tran,

Nguyen,

Pham

et al. 2023

Applied Sciences

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In this study, chemical components, α-glucosidase inhibitory activities, and molecular modelling studies of the essential oil extracted from the Cleistocalyx operculatus leaves were investigated. In total, thirty compounds were identified using GC/MS, representing 98.3% of the oil. Of these, the two most dominant constituents of the essential oil were determined as (Z)-β-ocimene (30.4%) and allo-ocimene (31.6%). The α-glucosidase inhibitory experiments indicated that the essential oil exhibited potent α-glucosidase inhibitory activities, with IC50 values of 61.82 ± 3.91 µg/mL. For further investigation into inhibitory mechanisms, molecular docking simulations were performed to investigate structural interactions between two dominant constituents and the α-glucosidase protein. The simulation revealed that allo-ocimene (31.6%) and (Z)-β-ocimene (30.4%) have protein binding affinities of −5.358 and −5.330 kcal/mol, respectively. Moreover, molecular dynamic simulation indicated that the complexes of two compounds and the target protein were stable over 100 ns. Overall, these findings suggest that the essential oil of C. operculatus leaves could be a natural source of potential α-glucosidase inhibitors.

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“…In fact, an essential oil of C. operculatus presents antioxidative properties and suppresses the expression of pro-inflammatory cytokines such as TNFα and IL-1β, and thus exerts an anti-inflammatory effect [ 16 ]. This essential oil can be used topically to treat burn wounds [ 17 ]. DMC effectively protects cells from oxidative injuries.…”

Section: Antioxidative Activitymentioning

confidence: 99%

Mechanistic insights into dimethyl cardamonin-mediated pharmacological effects: A double control of the AMPK-HMGB1 signaling axis

Bailly

Vergoten

2020

Life Sciences

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Dimethyl cardamonin (DMC) has been isolated from diverse plants, notably from Cleistocalyx operculatus . We have reviewed the pharmacological properties of this natural product which displays anti-inflammatory, anti-hyperglycemic and anti-cancer properties. The pharmacological activities essentially derive from the capacity of DMC to interact with the protein targets HMGB1 and AMPK. Upon binding to HMGB1, DMC inhibits the nucleocytoplasmic transfer of the protein and its extracellular secretion, thereby blocking its alarmin function. DMC also binds to the AMP site of AMPK to activate phospho-AMPK and then to trigger downstream signals leading to the anti-inflammatory and anti-hyperglycemic effects. AMPK activation by DMC reinforces inhibition of HMGB1, to further reduce the release of the alarmin protein, likely contributing to the anticancer effects. The characterization of a tight control of DMC over the AMPK-HMGB1 axis not only helps to explain the known activities of DMC but also suggests opportunities to use this chalcone to treat other pathological conditions such as the acute respiratory distress syndrome (which affects patients with COVID-19). DMC structural analogues are also evoked.

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Potential Use of Essential Oil Isolated fromCleistocalyx operculatusLeaves as a Topical Dermatological Agent for Treatment of Burn Wound

Cited by 10 publications

References 20 publications

In-vitro antibacterial activity of the fractions from Cleistocalyx operculatus (Roxb.) Merr. et Perry against Staphylococcus aureus

In-vitro antibacterial activity of the fractions from Cleistocalyx operculatus (Roxb.) Merr. et Perry against Staphylococcus aureus

Chemical Composition, Anti-α-Glucosidase Activity, and Molecular Modelling Studies of Cleistocalyx operculatus Essential Oil

Mechanistic insights into dimethyl cardamonin-mediated pharmacological effects: A double control of the AMPK-HMGB1 signaling axis

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