Potential Use of Plectranthus amboinicus in the Treatment of Rheumatoid Arthritis

Abstract

Plectranthus amboinicus (P. amboinicus) is a folk herb that is used to treat inflammatory diseases or swelling symptoms in Taiwan. We investigated therapeutic efficacy of P. amboinicus in treating Rheumatoid Arthritis (RA) using collagen-induced arthritis animal model. Arthritis was induced in Lewis rats by immunization with bovine type II collagen. Serum anti-collagen IgG, IgM and C-reactive protein (CRP) were analyzed. To understand the inflammation condition of treated animals, production of TNF-α, IL-6 and IL-1β from peritoneal exudates cells (PEC) were also analyzed. P. amboinicus significantly inhibited the footpad swelling and arthritic symptoms in collagen-induced arthritic rats, while the serum anti-collagen IgM and CRP levels were consistently decreased. The production of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β were also decreased in the high dosage of P. amboinicus group. Here, we demonstrate the potential anti-arthritic effect of P. amboinicus for treating RA, which might confer its anti-rheumatic activity. This differs the pharmacological action mode of indomethacin.

Evaluation of genotypic wheat bran varieties for nutraceutical compounds

“…The saturated fatty acids ranged from 17.9 to 36.7% while the monounsaturated fatty acids ranged between 13.4 and 28.1%. Wheat bran rich in PUFA, essential fatty acids were 56% in DWR 1006 variety, followed by CWB at 55%, which are comparable with earlier reports of Chang et al (2010). Presence of high amount of linoleic acid (18:2) as observed in WB oil is a good source of x-6 fatty acids along with the small amount of x-3 fatty acids.…”

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

“…RA is a type of chronic, systemic autoimmune disease which has the predominant feature of symmetrical polyarthritis, and anti-inflammatory analgesic symptomatic treatments, which would delay the development of the disease, offer the major therapeutic options (2,16). Local inflammation of the joints is a key link in the process of its pathogenesis; bone loss or damage caused by inflammation is the result of changes to the joints in RA, and symptoms of pain associated with joint swelling are often the most severe symptoms of which the patient complains (9).…”

“…Previous studies have identified that, in the limb joints of a mouse RA model, the mice have the same T-cell receptor (TCR) Vβ clone type T cells. However, as the development of the disease progresses, the numbers of this type of clone T cell increase gradually, whereas those of other TCR Vβ clone type T cells are gradually reduced: Therefore, this T cell clone type may be associated with the pathological changes of arthritis (1)(2)(3). Collagen-induced arthritis (CIA) is associated with pathogenetic and pathological changes that are similar to those of RA, and so CIA is often used as a model of human RA (4).…”

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