Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Sawant, Prashant D.

doi:10.3390/cosmetics5010008

Cited by 6 publications

(5 citation statements)

References 109 publications

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“…As the best known role of nitrones is to scavenge anion superoxide and hydroxyl radicals, they are sometimes classified as antioxidant therapeutics proposed for a wide variety of medicinal indications and have been used for therapy of various conditions such as neurodegeneration, cardiovascular disease, stroke, and cancer [13,14], in antipollution cosmetics, noise-induced neural degeneration, elimination of nociceptive behavior, and for the protection of retina from light-induced damage [14–17]. Differences in the activity of spin-traps and classical antioxidants (enzymatic or nonenzymatic) are that the latter may indiscriminately convert both normal oxygen and ROS molecules to water alone, leading to deep tissue hypoxia.…”

Section: Introductionmentioning

confidence: 99%

“…Differences in the activity of spin-traps and classical antioxidants (enzymatic or nonenzymatic) are that the latter may indiscriminately convert both normal oxygen and ROS molecules to water alone, leading to deep tissue hypoxia. Spin-traps react with the ROS by intercepting it before any damage is done and PBN seems to be the least toxic of nitrones [14]. PBN itself was able to act preventively and/or therapeutically in rat models of glioma, the choline deficiency liver cancer model, and the mouse APCMin/+ colon cancer model [13] and it can probably act similarly on other malignancies.…”

Section: Introductionmentioning

confidence: 99%

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A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic

Sobočan

Bojanac

Sinčić

et al. 2019

Stem Cells and Development

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The spin-trap free radical scavenger N -tert-butyl-α-phenylnitron (PBN) ameliorated effects of several teratogens involving reactive oxygen species (ROS). We investigated for the first time whether PBN could ameliorate teratogenesis induced by a DNA hypomethylating hematological therapeutic 5-azacytidine (5azaC). At days 12 and 13 of gestation, Fisher rat dams were pretreated by an i.v. injection of PBN (40 mg/kg) and 1 h later by an i.p. injection of 5azaC (5mg/kg). Development was analyzed at gestation day 15 in embryos and day 20 in fetuses. PBN alone did not significantly affect development. PBN pretreatment restored survival of 5azaC-treated dams' embryos to the control level, restored weight of embryos and partially of fetuses, and partially restored crown-rump lengths. PBN pretreatment converted limb adactyly to less severe oligodactyly. PBN pretreatment restored global DNA methylation level in the limb buds to the control level. Cell proliferation in limb buds of all 5azaC-treated dams remained significantly lower than in controls. In the embryonic liver, PBN pretreatment normalized proliferation diminished significantly by 5azaC; whereas in embryonic vertebral cartilage, proliferation of all 5azaC-treated dams was significantly higher than in PBN-treated dams or controls. Apoptotic indices significantly enhanced by 5azaC in liver and cartilage were not influenced by PBN pretreatment. However, PBN significantly diminished ROS or reactive nitrogen species markers nitrotyrosine and 8-hydroxy-2′deoxyguanosine elevated by 5azaC in embryonic tissues, and, therefore, activity of this DNA hypomethylating agent was associated to the activation of free radicals. That pretreatment with PBN enhanced proliferation in the liver and not in immature tissue is interesting for the treatment of 5azaC-induced hepatotoxicity and liver regeneration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic

Sobočan

Bojanac

Sinčić

et al. 2019

Stem Cells and Development

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“…As mentioned before, the skin is an important organ that protects us from the environment. For this reason, it is necessary to ensure the skin health also by using cleansers, which are surfactants used to reduce sebum, remove make-up residuals or exogenous contaminants such as sweat, pollution or dirt, and promote normal exfoliation [233][234][235][236][237]. However, the repeated and prolonged interaction between these surfactants and the proteins or lipids of stratum corneum could weaken the skin barrier function.…”

Section: Skin Cleanersmentioning

confidence: 99%

The Use of Calcium Phosphates in Cosmetics, State of the Art and Future Perspectives

2021

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Calcium phosphates (CaPs) belong to a class of biomimetic materials widely employed for medical applications thanks to their excellent properties, such as biodegradability, biocompatibility and osteoinductivity. The recent trend in the cosmetics field of substituting potentially hazardous materials with natural, safe, and sustainable ingredients for the health of consumers and for the environment, as well as the progress in the materials science of academics and chemical industries, has opened new perspectives in the use of CaPs in this field. While several reviews have been focused on the applications of CaP-based materials in medicine, this is the first attempt to catalogue the properties and use of CaPs in cosmetics. In this review a brief introduction on the chemical and physical characteristics of the main CaP phases is given, followed by an up-to-date report of their use in cosmetics through a large literature survey of research papers and patents. The application of CaPs as agents in oral care, skin care, hair care, and odor control has been selected and extensively discussed, highlighting the correlation between the chemical, physical and toxicological properties of the materials with their final applications. Finally, perspectives on the main challenges that should be addressed by the scientific community and cosmetics companies to widen the application of CaPs in cosmetics are given.

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“…Free radicals cause oxidative damage to different molecules, such as lipids, proteins and nucleic acids and thus are involved in the initiation phase of some degenerative diseases . Research has shown that free radical mediated oxidative stress is among the major causative factors in induction of many chronic and degenerative diseases including atherosclerosis, ischemic heart disease, ageing, diabetes mellitus, cancer, immunosuppression, neurodegenerative diseases and others 60,61 .…”

Section: Total Antioxidant Capacity (Tac)mentioning

confidence: 99%

Synergistic Efficacy of Phytochemical, Antioxidant and Bactericidal Properties of the Aerial Essential Oil of Laggera crispata

S¹,

Anuoluwa²,

F³

et al. 2021

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This study was undertaken to provide more scientific information about the phytochemical composition of Laggera crispata known for its medicinal uses. Essential oil was isolated by hydro-distillation, analysed using GC-MS, UV-Visible Spectrophotometer and other established biochemical assays were used for the study. The GC-MS analysis of the aerial essential oil of L. crispata showed the presence of 35 medicinal organic compounds making up 84.4% of the oil. The most abundant component was a phenolic compound called 2-tert-Butyl-1,4-dimethoxybenzene (54.5%). The other major terpenoids present in the oil were α-humulene (6.9%) and (+)-sabinene (5.9%). The TPC, TFC, TAA and TAC values of the aerial essential oil of L. crispata were 172.75±0.00 µgmg -1 GAE, 48.69±0.00 µgmg -1 QE, 61.85±0.00 µgmg -1 AAE and 726.92±0.00 µgmg -1 AAE respectively. DPPH IC 50 and AAI values of the essential oil were 1.5 µgml -1 and 26.7. The essential oil displayed varying inhibitory activities against Gram-positive and Gram-negative bacteria with zones of inhibition ranging from 08-30 mm. The in vitro pharmacological activities added scientific support to the use of L. crispata in alternative and complementary medicine. The essential oil of L. crispata grown in Nigeria will play beneficial roles in human and animal health and therefore a research on this plant might be of great value in drug industries.

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Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Cited by 6 publications

References 109 publications

A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic

A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic

The Use of Calcium Phosphates in Cosmetics, State of the Art and Future Perspectives

Synergistic Efficacy of Phytochemical, Antioxidant and Bactericidal Properties of the Aerial Essential Oil of Laggera crispata

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