Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads

Khoder, Mouhamad; Gbormoi, Henry K.; Ryan, Ali; Karam, Ayman; Alany, Raid G.

doi:10.3390/pharmaceutics11020083

Cited by 16 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…. At various time intervals, aliquots of 5ml were withdrawn and replaced with the same volume of fresh dissolution medium to maintain the sink conditions and the withdrawn samples were analyzed by UV spectrophotometer (EMCLAB, Germany) at 266 nm (27,28) .…”

Section: In-vitro Release Study Of 5-fu Nanospongesmentioning

confidence: 99%

Synthesis and evaluation of B-cyclodextrin Based Nanosponges of 5- Fluorouracil by Using Ultrasound Assisted Method

Jasim¹,

Alhammid²,

Abdulrasool³

2020

IJPS

View full text Add to dashboard Cite

CD-nanosponges were prepared by crosslinking B-CD with diphenylcarbonate (DPC) using ultrasound assisted technique. 5-FU was incorporated with NS by freeze drying, and the phase solubility study, complexation efficiency (CE) entrapment efficiency were performed. Also, the particle morphology was studied using SEM and AFM. The in-vitro release of 5-FU from the prepared nanosponges was carried out in 0.1N HCl. 5-FU nanosponges particle size was in the nano size. The optimum formula showed a particle size of (405.46±30) nm, with a polydispersity index (PDI) (0.328±0.002) and a negative zeta potential (-18.75±1.8). Also the drug entrapment efficiency varied with the CD: DPC molar ratio from 15.6 % to 30%. The SEM and AFM showed crystalline and porous nature of the nanosponges. The in vitro drug release study of the selected formula 5-FUNS2 exhibited the fastest dissolution rate which is 56% in the first hr. Different molar ratios of (cyclodextrin to crosslinker) (CD: DPC) has a proficient effect on complexation efficiency (CE), apparent stability constant (Kst) and entrapment efficiency of 5-FU. 5-FUNS2 with (1:4) molar ratio showed the best result of CE, Kst and entrapment efficiency. 5-FUNS2 gave a higher release rate than the 5-FU-BCD inclusion complex and 5-FU solution. Surface morphology of the prepared nanosponges by SEM, AFM indicate that nanosized and highly porous nanosponges was obtained. The overall results suggest that cyclodextrin nanosponges could be a promising 5-FU delivery system utilizing the suitable formula.

show abstract

Section: In-vitro Release Study Of 5-fu Nanospongesmentioning

confidence: 99%

Synthesis and evaluation of B-cyclodextrin Based Nanosponges of 5- Fluorouracil by Using Ultrasound Assisted Method

Jasim¹,

Alhammid²,

Abdulrasool³

2020

IJPS

View full text Add to dashboard Cite

show abstract

“…Intestinal permeation enhancers (PEs) are agents used to improve the oral delivery of therapeutic drugs with otherwise poor bioavailability in order to overcome the intestinal permeability barrier. [1][2][3] Under physiological conditions, this barrier acts as a strong selective filter to ensure efficient absorption of dietary nutrients, vitamins, and minerals whilst simultaneously preventing luminal pathogens from gaining entry into the organism. 4,5 Several components, including synthesis and luminal sequestering of antibodies, mucus and digestive enzymes, contribute to a strong combined defense of the host, but the ultimate obstacle preventing oral drugs from gaining access to the wider organism is the intestinal epithelium.…”

Section: Introductionmentioning

confidence: 99%

Probing paracellular -versustranscellular tissue barrier permeability using a gut mucosal explant culture system

Danielsen

Hansen

2019

Tissue Barriers

View full text Add to dashboard Cite

Intestinal permeation enhancers (PEs), i.e. agents improving oral delivery of therapeutic drugs with poor bioavailability, may typically act by two principally different mechanisms: to increase either transcellular -or paracellular passage across the epithelium. With the aim to define these different modes of action in a small intestinal mucosal explant system, the transcellular-acting PE sodium dodecyl sulfate (SDS) was compared to the paracellular-acting PE ethylenediaminetetraacetic acid (EDTA), using several fluorescent polarand lipophilic probes. Here, SDS rendered the enterocyte cell membranes leaky for the relatively small polar tracers Lucifer yellow and a 3 kD Texas red-conjugated dextran, but most conspicuously SDS blocked constitutive endocytosis from the brush border. In contrast, the main action of EDTA was to increase paracellular passage across the epithelium of both polar probes, including 10and 70 kDa dextrans and lipophilic probes, visualized by distinct stripy lateral staining of enterocytes and/or accumulation in the lamina propria. In addition, EDTA caused a loss of epithelial cell polarity by opening tight junctions for diffusion of domain-specific basolateral/apical cell membrane protein markers into the opposite domains. By transmission electron microscopy, SDS caused the formation of vacuoles and vesicle-like structures at the lateral cell membranes. In contrast, EDTA led to a bulging of the whole enterocyte apex, resulting in a "cobblestone" appearance of the epithelium, probably caused by an extreme contraction of the perijunctional actomyosin ring. We conclude that the mucosal explant system is a convenient model for predicting transcellular/paracellular modes of action of novel prospective PEs. ARTICLE HISTORYIntestinal permeation enhancers (PEs); ethylenediaminetetraacetic acid (EDTA); sodium dodecyl sulphate (SDS); small intestine; enterocyte; brush border CONTACT E. Michael Danielsen

show abstract

“…earlier, where the solubility of albumin-alginate Maillard reaction conjugates suffered when subjected to a prolonged Maillard reaction time [39]. We used FT-IR to comprehend the short-range molecular order of the conjugates.…”

Section: Resultsmentioning

confidence: 99%

Macromolecular design of folic acid functionalized amylopectin–albumin core–shell nanogels for improved physiological stability and colon cancer cell targeted delivery of curcumin

Borah

Das

Mukhopadhyay

et al. 2020

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

show abstract

Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads

Cited by 16 publications

References 35 publications

Synthesis and evaluation of B-cyclodextrin Based Nanosponges of 5- Fluorouracil by Using Ultrasound Assisted Method

Synthesis and evaluation of B-cyclodextrin Based Nanosponges of 5- Fluorouracil by Using Ultrasound Assisted Method

Probing paracellular -versustranscellular tissue barrier permeability using a gut mucosal explant culture system

Macromolecular design of folic acid functionalized amylopectin–albumin core–shell nanogels for improved physiological stability and colon cancer cell targeted delivery of curcumin

Contact Info

Product

Resources

About