Potential use of ubiquinol and d-ribose in patients with heart failure with preserved ejection fraction

Pierce, Janet D.; Shen, Qiuhua; Vacek, James L.; Rahman, Faith; Krueger, Kathryn J; Gupta, Bhanu; Hiebert, John M.

doi:10.1016/j.amsu.2020.05.009

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…At the same time, the hypertrophic ventricle increases the load of the heart, leading to heart failure, thus causing oxidative stress and in ammation. The decrease of oxygen utilization rate directly reduces the synthesis of ATP, and ribose, as the raw material of nucleotides, is accumulated [31].…”

Section: Discussionmentioning

confidence: 99%

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Zhang¹,

Xu²,

Gao³

et al. 2023

Preprint

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Background Hypertension is a kind of clinical syndrome, characterized by the increase of systemic arterial pressure. There is a lack of identifiable triggers and predictors of hypertensive disease in response to treatment at rest and during exercise. In this study, a mathematical model was used to screen and compare the indicators and related changes at rest and during exercise between normotensive and hypertensive individuals. Methods Blood pressure and ultrasound-related indicators, blood biochemical indicators and metabolic compounds were collected and logistic regression model and Principal component analysis (PCA) were used to explore the differences of indexes at rest and in different exercise states in healthy and hypertensive patients. An indicator change map for hypertension is established. Results The results reveal that hypertension is not only related to oxidative stress, inflammatory reaction and fatty acid oxidation, but also involves various amino acid metabolism. The defined mathematical models and indicators changes during exercise might be helpful for early screening of hypertension and future studies are needed to explore their value on prevention and control of hypertension. Conclusion The research shows that the main regulation indicators at different exercise states differ significantly in the normal group and the hypertensive group. The key indicators of the normal group are blood pressure and ultrasound related indicators, while those of the hypertensive group are metabolites related to lactic acid metabolism, glycolysis, aerobic oxidation and lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Zhang¹,

Xu²,

Gao³

et al. 2023

Preprint

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“…The furanose ring structure of D-ribose is a precursor to the structures of nucleic acids (DNA and RNA), coenzymes (NADH, NADPH, FADH 2 , and acetyl coenzyme A), and energy molecules (ATP, GTP, etc.) (33,35). D-ribose is synthesized in the cell's cytosol by the pentose phosphate pathway (PPP) (33).…”

Section: Mitochondria and Bioenergeticsmentioning

confidence: 99%

“…This pathway is also known as the hexose monophosphate shunt (HMS) due to it "shunting" glucose-6-phosphate (G6P) from other metabolic pathways to the PPP. Since G6P is used in other pathways such as glycolysis, gluconeogenesis, and glycogenesis, the first step in the PPP is regulated by glucose-6-phosphate dehydrogenase (G6PDH), an enzyme that is stimulated by increasing levels of NADP + (35,36). The first half of the PPP is considered the oxidative phase.…”

Section: Mitochondria and Bioenergeticsmentioning

confidence: 99%

“…The salvage pathway recycles existing nitrogenous bases and adds them to PRPP. The de novo pathway uses simple molecules such as amino acids to create the nitrogenous bases that attaches to the pentose ring (35,38,39). NAD + and NADP can be synthesized from PRPP by the salvage pathway with nicotinamide and the de novo pathway with tryptophan (40).…”

Section: Mitochondria and Bioenergeticsmentioning

confidence: 99%

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Mitochondrial bioenergetics and D-ribose in HFpEF: a brief narrative review

Krueger¹,

Rahman²,

Shen³

et al. 2021

Ann Transl Med

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In this review article, we briefly describe the status of treatment options for HFpEF and the role of mitochondrial dysfunction in the pathogenesis of HFpEF as an alternative therapeutic target. We also examine the mechanisms of D-ribose in cellular energy production and discuss the potential disadvantages and benefits of supplemental use of D-ribose in patients with HFpEF.Background: Heart failure is a major cardiovascular disease that impacts over 6 million Americans and is one of the leading causes for morbidity and mortality. Patients with heart failure often experience shortness of breath and fatigue along with impaired physical capacity, all leading to poor quality of life. As a subtype of heart failure, heart failure with preserved ejection fraction (HFpEF) is characterized with impaired diastolic function. Currently, there are no effective treatments specifically for HFpEF, thus clinicians and researchers are searching for therapies to improve cardiac function. Emerging evidence indicate that mitochondrial dysfunction and impaired cardiac bioenergetics are among the underlying mechanisms for HFpEF. There is increased interest in investigating the use of supplements such as D-ribose to enhance mitochondrial function and improve production of adenosine triphosphate (ATP).

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Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat

et al. 2023

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Potential use of ubiquinol and d-ribose in patients with heart failure with preserved ejection fraction

Cited by 5 publications

References 38 publications

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Mitochondrial bioenergetics and D-ribose in HFpEF: a brief narrative review

Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat

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