Potential Utility of Foveal Morphology in Preterm Infants Measured Using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Anwar, Samira; Nath, Mintu; Patel, Aarti; Lee, Helena; Brown, Samantha; Gottlob, Irène; Proudlock, Frank A

doi:10.1097/iae.0000000000002622

Cited by 25 publications

(21 citation statements)

References 43 publications

(67 reference statements)

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“…Handheld OCT has been utilized to describe the normal development of the optic nerve 14 and fovea 15 in children, with excellent feasibility. Furthermore, handheld OCT has been utilized in numerous pediatric conditions, 16 including primary congenital glaucoma, 17 nystagmus, 18 foveal hypoplasia, 19,20 optic nerve hypoplasia, 21 achromatopsia, 22 retinopathy of prematurity, 23 and craniopagus twins, 24 among others. Other OCT devices have demonstrated potential for detecting papilledema and IH in craniosynostosis, but handheld OCT has not yet been used in this patient population.…”

Section: Neurosurgical Intervention Involves Expanding Thementioning

confidence: 99%

Feasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis

Rufai

Bowman

Bunce

et al. 2021

Trans. Vis. Sci. Tech.

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To determine whether handheld optical coherence tomography (OCT) is feasible and repeatable in children with craniosynostosis.Methods: This was a prospective cross-sectional study. Children with syndromic and non-syndromic craniosynostosis 0 to 18 years of age were recruited between February 13, 2020, and October 1, 2020. Main outcome measures included feasibility (patient recruitment and handheld OCT success rates) and repeatability, which were assessed using intraclass correlation coefficients (ICCs) where repeated images of the optic nerve head (ONH) within the same visit were available. ONH parameters used for repeatability analysis included cup depth, width, and area; disc width; rim height; retinal thickness; retinal nerve fiber layer thickness; and Bruch's membrane opening minimum rim width.Results: Fifty children were approached, and all 50 (100%) were successfully recruited. Median age was 51.1 months (range, 1.9-156.9; interquartile range, 37.0-74.2), and 33 of the children (66%) were male. At least one ONH image was obtained in 43 children (86%), and bilateral ONH imaging was successful in 38 children (76%). Factors boosting the likelihood of success included good understanding and cooperation of the child and parent/guardian and availability of an assistant. Repeatability analysis was performed in 20 children, demonstrating good repeatability (ICC range, 0.77-0.99; the majority exceeded 0.90). OCT correctly identified two cases of intracranial hypertension, one of which was undetected by prior fundoscopy. Conclusions:Handheld OCT is feasible and repeatable in children with syndromic and non-syndromic forms of craniosynostosis.Translational Relevance: Our handheld OCT approach could be used for the clinical surveillance of children with craniosynostosis.

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Section: Neurosurgical Intervention Involves Expanding Thementioning

confidence: 99%

Feasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis

Rufai

Bowman

Bunce

et al. 2021

Trans. Vis. Sci. Tech.

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“…26 OCT has been used to describe the normal development of the optic nerve 27 and fovea 27 28 in children. OCT has also been used in a wide range of conditions within paediatric ophthalmology, including retinopathy of prematurity, 29 retinoblastoma, 30 nystagmus, 31 albinism, 32 achromatopsia, 33 foveal hypoplasia, 34 optic nerve hypoplasia, 35 primary congenital glaucoma, 36 microcephaly 37 and others. Furthermore, OCT has been successfully used as a diagnostic tool in a variety of conditions associated with ICH, including idiopathic ICH, craniosynostosis and hydrocephalus.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol

2020

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IntroductionIntracranial hypertension (ICH) in children can have deleterious effects on the brain and vision. It is notoriously difficult to estimate intracranial pressure (ICP) in children and existing methods deliver suboptimal diagnostic accuracy to be used as screening tools. Optical coherence tomography (OCT) may represent a valuable, non-invasive surrogate measure of ICP, as has been demonstrated in a number of associated conditions affecting adults. More recently, OCT has been employed within the paediatric age group. However, the role of OCT in detecting ICH in children has not been rigorously assessed in a systematic review for all relevant conditions. Here, we propose a systematic review protocol to examine the role of OCT in the detection of ICH in children.Methods and analysisElectronic searches in the Cochrane Central Register of Controlled Trials, Medline, Embase, Web of Science and PubMed will identify studies featuring OCT in detecting ICH in children. Two independent screeners will identify studies for inclusion using a screening questionnaire. The systematic search and screening will take place between 2 April 2020 and 1 June 2020, while we aim to complete data analysis by 1 September 2020. Quality assessment will be performed using the National Institutes of Health Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. The primary outcome measure is the sensitivity and specificity of OCT in detecting ICH in children. Secondary outcomes measures include conditions associated with ICH per study, direct ICP monitoring, sensitivity and specificity of other measures for ICP and OCT parameters used.Ethics and disseminationEthical approval is not required for the proposed systematic review as no primary data will be collected. The findings will be disseminated through presentations at scientific meetings and peer-reviewed journal publication.PROSPERO registration numberCRD42019154254.

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“…OCT has been applied to ROP in the research setting: it has provided insight into the in vivo development of the vascular and nonvascular tissue of the premature retina, [25][26][27][28][29] and illustrates subclinical features of ROP not visible on ophthalmoscopic examination. [30][31][32][33][34][35][36] One study used OCT to generate three-dimensional vascular maps and calculated a Vascular Abnormality Score by OCT (VASO), which correlated well with the presence of plus disease. 37 Two-dimensional en face projections of OCT volumes illustrate retinal vascular patterns and resemble fundus photographs that ophthalmologists and analytic software are accustomed to grading for plus disease.…”

Section: Introductionmentioning

confidence: 99%

Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

Seely

Wang

Tai

et al. 2020

Trans. Vis. Sci. Tech.

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To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (ROP). Methods: In this exploratory study, we selected images from eyes with a range of ROP vascular disease, prospectively acquired from preterm infants using an investigational, noncontact, handheld, bedside swept-source OCT. We autosegmented OCT volumes using custom infant-specific software, extracted RVSV-OCT images from volumetric data bracketed around the retinal pigment epithelium, and automontaged the resulting RVSV-OCT images. Three masked ophthalmologists graded the RVSV-OCT montages as plus, pre-plus, or neither and ranked them by relative vascular disease severity. Results: We selected images from 17 imaging sessions (7 plus, 4 pre-plus, 6 neither on clinical examination). On review, 15/17 (88%) RVSV-OCT montages were gradable for plus, pre-plus, or neither and all 17 montages were rankable for relative severity. Intergrader agreement for plus, pre-plus, or neither grading was good (κ, 0.67; 95% confidence interval, 0.42-0.86) and for relative severity ranking was excellent (intraclass correlation coefficient, 0.98; 95% confidence interval, 0.96-0.99). Conclusions: Our novel automatic processing method can create RVSV-OCT montages optimized for retinal vessel visualization for ROP screening. Although our data support the feasibility of using RVSV-OCT montages for ranking relative vascular disease severity, there is room for improved OCT image capture and processing methods in preterm infants screened for ROP. Translational Relevance: Creation and grading of RVSV-OCT images could eventually be integrated into an alternative method for ROP screening.

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Potential Utility of Foveal Morphology in Preterm Infants Measured Using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Cited by 25 publications

References 43 publications

Feasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis

Feasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis

Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol

Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

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