Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease

Becker, James T.; Fabrizio, Melissa; Sudre, Gustavo; Haridis, Anna; Ambrose, Timothy; Aizenstein, Howard J.; Eddy, William F.; López, Oscar L.; Wolk, David A.; Parkkonen, Lauri; Bagić, Anto

doi:10.1016/j.jneumeth.2012.02.022

Cited by 25 publications

(17 citation statements)

References 47 publications

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“…Although some caution is warranted as MEG sensor-level data (i.e., magnetic field strength measurements) contains neural activity from a mix of many distinct brain areas, and it is tenuous to link such activity to particular brain regions. The other MEG study examined the reliability of MEG measurement, and provided preliminary evidence that broadband sensor-level data had good test-retest reliability after ∼24 weeks in both HIV-infected patients and controls [48]. Such findings are clearly supportive of using MEG to develop biomarkers for the early identification of HAND, and the current study also makes important contributions to this long-term goal.…”

Section: Discussionsupporting

confidence: 66%

Abnormal MEG Oscillatory Activity during Visual Processing in the Prefrontal Cortices and Frontal Eye-Fields of the Aging HIV Brain

et al. 2013

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ObjectiveShortly after infection, HIV enters the brain and causes widespread inflammation and neuronal damage, which ultimately leads to neuropsychological impairments. Despite a large body of neuroscience and imaging studies, the pathophysiology of these HIV-associated neurocognitive disorders (HAND) remains unresolved. Previous neuroimaging studies have shown greater activation in HIV-infected patients during strenuous tasks in frontal and parietal cortices, and less activation in the primary sensory cortices during rest and sensory stimulation.MethodsHigh-density magnetoencephalography (MEG) was utilized to evaluate the basic neurophysiology underlying attentive, visual processing in older HIV-infected adults and a matched non-infected control group. Unlike other neuroimaging methods, MEG is a direct measure of neural activity that is not tied to brain metabolism or hemodynamic responses. During MEG, participants fixated on a centrally-presented crosshair while intermittent visual stimulation appeared in their top-right visual-field quadrant. All MEG data was imaged in the time-frequency domain using beamforming.ResultsUninfected controls had increased neuronal synchronization in the 6–12 Hz range within the right dorsolateral prefrontal cortex, right frontal eye-fields, and the posterior cingulate. Conversely, HIV-infected patients exhibited decreased synchrony in these same neural regions, and the magnitude of these decreases was correlated with neuropsychological performance in several cortical association regions.ConclusionsMEG-based imaging holds potential as a noninvasive biomarker for HIV-related neuronal dysfunction, and may help identify patients who have or may develop HAND. Reduced synchronization of neural populations in the association cortices was strongly linked to cognitive dysfunction, and likely reflects the impact of HIV on neuronal and neuropsychological health.

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Section: Discussionsupporting

confidence: 66%

Abnormal MEG Oscillatory Activity during Visual Processing in the Prefrontal Cortices and Frontal Eye-Fields of the Aging HIV Brain

et al. 2013

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“…Such a repeated session would have provided a powerful control for natural variability over time in WM responses. We did not collect a second MEG session in controls because of the cost of MEG, and because there are many publications that have shown high test–retest reliability for MEG metrics (Ahonen, Huotilainen, & Brattico, 2016; Becker et al, 2012; Edgar et al, 2015; Martín-Buro, Garcés, & Maestú, 2016; Tan, Gross, & Uhlhaas, 2015). Importantly, Ahonen and colleagues (2016) found that neurophysiological responses during an N -back WM task were highly reliable.…”

Section: Discussionmentioning

confidence: 99%

Attention training improves aberrant neural dynamics during working memory processing in veterans with PTSD

McDermott

Badura-Brack

Becker

et al. 2016

Cogn Affect Behav Neurosci

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Posttraumatic stress disorder (PTSD) is associated with executive functioning deficits, including disruptions in working memory (WM). Recent studies suggest that attention training reduces PTSD symptomatology, but the underlying neural mechanisms are unknown. We used high-density magnetoencephalography (MEG) to evaluate whether attention training modulates brain regions serving WM processing in PTSD. Fourteen veterans with PTSD completed a WM task during a 306-sensor MEG recording before and after 8 sessions of attention training treatment. A matched comparison sample of 12 combat-exposed veterans without PTSD completed the same WM task during a single MEG session. To identify the spatiotemporal dynamics, each group's data were transformed into the time-frequency domain, and significant oscillatory brain responses were imaged using a beamforming approach. All participants exhibited activity in left hemispheric language areas consistent with a verbal WM task. Additionally, veterans with PTSD and combat-exposed healthy controls each exhibited oscillatory responses in right hemispheric homologue regions (e.g., right Broca's area); however, these responses were in opposite directions. Group differences in oscillatory activity emerged in the theta band (4–8 Hz) during encoding and in the alpha band (9–12 Hz) during maintenance and were significant in right prefrontal and right supramarginal and inferior parietal regions. Importantly, following attention training, these significant group differences were reduced or eliminated. This study provides initial evidence that attention training improves aberrant neural activity in brain networks serving WM processing.

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“…However, caution is warranted as sensor-level MEG data (i.e., magnetic field strength measurements) contains neural activity from a mix of many different brain areas, and it is tenuous to link such activity to specific brain regions. Another relevant MEG study examined measurement reliability, and provided preliminary evidence that broadband sensor-level data had good test-retest reliability after ~24 weeks in both HIV-infected patients and uninfected controls (Becker et al 2012b). Such findings are strongly supportive of using MEG methods to develop biomarkers for the early identification of HAND, and the current study also makes important contributions to this long-term goal.…”

Section: Discussionmentioning

confidence: 99%

Functional Brain Abnormalities During Finger-Tapping in HIV-Infected Older Adults: A Magnetoencephalography Study

Wilson

Heinrichs‐Graham

Robertson

et al. 2013

J Neuroimmune Pharmacol

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Despite the availability of combination antiretroviral therapy, at least mild cognitive dysfunction is commonly observed in HIV-infected patients, with an estimated prevalence of 35-70%. Neuropsychological studies of these HIV-associated neurocognitive disorders (HAND) have documented aberrations across a broad range of functional domains, although the basic pathophysiology remains unresolved. Some of the most common findings have been deficits in fine motor control and reduced psychomotor speed, but to date no neuroimaging studies have evaluated basic motor control in HAND. In this study, we used magnetoencephalography (MEG) to evaluate the neurophysiological processes that underlie motor planning in older HIV-infected adults and a matched, uninfected control group. MEG is a noninvasive and direct measure of neural activity with good spatiotemporal precision. During the MEG recording, participants fixated on a central crosshair and performed a finger-tapping task with the dominant hand. All MEG data was corrected for head movements, preprocessed, and imaged in the time-frequency domain using beamforming methodology. All analyses focused on the pre-movement beta desynchronization, which is known to be an index of movement planning. Our results demonstrated that HIV-1-infected patients have deficient beta desynchronization relative to controls within the left/right precentral gyri, and the supplementary motor area. In contrast, HIV-infected persons showed abnormally strong beta responses compared to controls in the right dorsolateral prefrontal cortex and medial prefrontal areas. In addition, the amplitude of beta activity in the primary and supplementary motor areas correlated with scores on the Grooved Pegboard test in HIV-infected adults. These results demonstrate that primary motor and sensory regions may be particularly vulnerable to HIV-associated damage, and that prefrontal cortices may serve a compensatory role in maintaining motor performance levels in infected patients.

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Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease

Cited by 25 publications

References 47 publications

Abnormal MEG Oscillatory Activity during Visual Processing in the Prefrontal Cortices and Frontal Eye-Fields of the Aging HIV Brain

Abnormal MEG Oscillatory Activity during Visual Processing in the Prefrontal Cortices and Frontal Eye-Fields of the Aging HIV Brain

Attention training improves aberrant neural dynamics during working memory processing in veterans with PTSD

Functional Brain Abnormalities During Finger-Tapping in HIV-Infected Older Adults: A Magnetoencephalography Study

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