Potential value of circulating microRNA-126 and microRNA-210 as biomarkers for type 2 diabetes with coronary artery disease

Abstract

Plasma miR-126 and miR-210 levels may be biomarkers for diabetes with or without CAD.

Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation

“…Whether the detected miRNAs are specific of MPM or rather indicative of a disease status of the subjects remains an unsolved question. Just to make some examples, alteration of circulating miR-126 expression has been associated not only with MPM but also with other neoplastic conditions [e.g., NSCLC (96) or colorectal carcinoma (97)], and with non-neoplastic conditions such as diabetes (98); in addition, altered expression of circulating miR-103a-3p was associated also with prostate cancer (99).…”

British Journal of Biomedical Science in 2018: what have we learned?

“…Several environmental (obesity) and genetic factors (such as microRNAs) contribute to the multiple pathophysiological disturbances that are responsible for impaired glucose homeostasis in this disease. Amr and colleagues [13] hypothesised that plasma miR-126 and miR-210 are linked to coronary artery disease (CAD) in diabetes patients, recruiting 20 healthy volunteers and 100 patients with diabetes (54 patients without CAD and 46 patients with CAD). Plasma miR-126 and miR-210 (assessed by quantitative RT-PCR) were mean (SD) 0.38 (0.03) and 5.3 (0.56) in diabetes alone vs. 0.08 (0.03) and 21.44 (0.97) in diabetes with CAD, respectively (both P < 0.0001).…”

“…Pathogenesis is not well defined, but it is possible that genetic and environmental factors result in an aberrant immune response to a subset of commensal enteric bacteria. Hosseinpour et al [13] conducted a case-control study of 180 patients and 250 controls to evaluate variants in SNPs in genes for tumour suppressor protein p53 and miR-34b/c on the development of UC. They found that subjects with the p53 variant genotype (Pro/Pro) showed a significantly increased risk of UC relative to Arg/Arg carriers (Odds ratio 7.11, 95% CI 3.22-15.69; P < 0.001).…”

“…Histo(pathology) and cytology are no longer only about staining cells and tissues with dyes: as we have seen [6,11,[13][14][15], micro-RNA (miRNAs) are slowly insinuating their way into all disciplines of biomedical sciences. Tong and colleagues [5] recruited 101 patients with uterine sarcoma and 54 healthy subjects, measuring serum miR-152, miR-205, miR-222, miR-24, miR-150 and sirtuin-1 by qRT-PCR.…”

“…Auto-immune Autoantigen [21] SEPP1 and SEP 15 Breast Carcinoma DNA mutation [35] Genes linked to E. coli virulence Kidney Infections DNA mutation [31] miR-146b Thyroid Papillary cancer DNA mutation [18] P53 and miR-34b/c Colon Autoimmune Autoantigen [43] sMICA Lung Carcinoma DNA mutation [38] H. pylori genes Stomach Infection H. pylori [46] CA125, ferritin Ovary Cancer DNA mutation [54] Neutrophil/lymphocyte ratio, CRP, LFTs Liver Infection Various microbes [22] miR-27a, miR-196a, miR-146a Breast Cancer DNA mutation [13] miR-126, miR-210 Heart Atherosclerosis, diabetes Thrombosis, hyperglycaemia [47] S100A4 (metastatin) Ovary Cancer DNA mutation [23] p21 Brain Meningioma DNA mutation [36] 16S-23s RNA region Not applicable Infection S. pneumoniae [42] sMICA, PSA Prostate Cancer DNA mutation [37] Bacterial identification Not applicable Infection P. aeruginosa, B. cenocepacia [39] Genes in H. pylori and parasites Bowel Infection DNA mutation [52] Genes in HPV Anus and genitals Infection DNA mutation [51] Haemostasis The eye Atherosclerosis, diabetes Thrombosis, Hyperglycaemia [48] CEA, CA19-9, cytokeratin-1, mucin-1 Colon Cancer DNA mutation [50] LFTs, platelets Liver Fibrosis Hepatitis B virus [21] Detection of foetal DNA Not applicable Chromosome trisomy DNA mutation [14] SNPs in KCNJ11 and SDF-1β Not applicable Diabetes DNA mutation [16] Serum relaxin-2, PSA Prostate Cancer DNA mutation [17] Serum prolidase and SNP in prolidase Ovary Polycystia Endocrine [55] SNP in IL28B Liver Infection Hepatitis C virus [15] SNPs in TLR4 Kidney, Arteries Diabetes DNA mutation [25] SNPs in GST Cervix Cancer DNA mutation [44] SNPs in TLR3, TLR7, TLR8 Liver Infection Hepatitis C virus [28] Pri-miR-124-1 and STAT3 Stomach Cancer DNA mutation [49] Monocyte/granulocyte to lymphocyte ratio Liver Cancer DNA mutation [56] Leptin, HOMA Liver Fibrosis He...…”