Potentialités et intérêt du tissu adipeux dans la sclérodermie

Daumas, Aurélie; Eraud, Julia; Hautier, A.; Sabatier, Florence; Magalon, G.; Granel, B.

doi:10.1016/j.revmed.2013.08.007

Cited by 12 publications

(2 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, adipose tissue can be obtained relatively easily and offers an abundance of stem/stroma cells. These features suggest adipose-derived cell therapy as an attractive option, particularly for patients with ischaemic manifestations ( 78 ). While Granel et al ( 20 ) and Del Papa et al ( 8 , 22 ) showed similar results in the use of fat cells to reduce pain and in ulcer healing, although 2 different techniques were used to purify the cells, namely AD-SVF fractionation and autologous adipose tissue-derived cells without the digestion of fat tissue, respectively ( 79 – 81 ).…”

Section: Discussionmentioning

confidence: 99%

Locoregional Treatments for Digital Ulcers in Systemic Sclerosis: A Systematic Review

Costedoat¹,

Masson²,

Barnetche³

et al. 2021

Acta Derm Venereol

View full text Add to dashboard Cite

The management of digital ulcers in systemic sclerosis is difficult. While the 2017 European League Against Rheumatism (EULAR) guidelines clearly defined the use of systemic therapies for digital ulcers, little is known about the efficacy of locoregional treatments. The aim of this review is to systematically assess the spectrum of published locoregional therapies for digital ulcers. A total of 58 studies were included. Among the different locoregional treatment strategies described, injections of fat-derived cells and botulinum toxin showed promising results in the reduction of pain and the number of digital ulcers. By contrast, this review found that sympathectomy yielded disappointing results, with low rates of effectiveness and frequent recurrence. For other treatments, such as hyperbaric oxygen therapy, phototherapy (ultraviolet A), low-level light therapy, intermittent compression, Waon therapy, extracorporeal shockwave, vitamin E gel, and topical dimethyl sulphoxide, the conflicting results or limited published data reflected the low level of evidence. Larger randomized clinical trials are required to confirm the validity of promising techniques.

show abstract

Section: Discussionmentioning

confidence: 99%

Locoregional Treatments for Digital Ulcers in Systemic Sclerosis: A Systematic Review

Costedoat¹,

Masson²,

Barnetche³

et al. 2021

Acta Derm Venereol

View full text Add to dashboard Cite

show abstract

“…Thus adipose tissue is a valuable source of cells with reparative, angiogenic, antifibrotic, and immunomodulatory properties [6][7][8][9]. With the advantage of an abundant supply of fat tissue, ease of harvest by liposuction, and high abundance of stem/stromal cells (compared to bone marrow), fat grafting and adipose-tissue-derived cellbased therapies are becoming attractive therapeutic options in SSc, especially for fibrosis and ischemic manifestations [10].…”

Section: Introductionmentioning

confidence: 99%

Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis

et al. 2023

View full text Add to dashboard Cite

Adipose tissue is recognized as a valuable source of cells with angiogenic, immunomodulatory, reparative and antifibrotic properties and emerged as a therapeutic alternative for the regeneration and repair of damaged tissues. The use of adipose-tissue-based therapy is expanding in autoimmune diseases, particularly in Systemic Sclerosis (SSc), a disease in which hands and face are severely affected, leading to disability and a decrease in quality of life. Combining the advantage of an abundant supply of fat tissue and a high abundance of stem/stromal cells, fat grafting and adipose tissue-derived cell-based therapies are attractive therapeutic options in SSc. This review aims to synthesize the evidence to determine the effects of the use of these biological products for face and hands treatment in the context of SSc. This highlights several points: the need to use relevant effectiveness criteria taking into account the clinical heterogeneity of SSc in order to facilitate assessment and comparison of innovative therapies; second, it reveals some impacts of the disease on fat-grafting success; third, an important heterogeneity was noticed regarding the manufacturing of the adipose-derived products and lastly, it shows a lack of robust evidence from controlled trials comparing adipose-derived products with standard care.

show abstract

Adipose tissue-derived regenerative cell-based therapies: Current optimisation strategies for effective treatment in aesthetic surgery

Shimizu

Ntege

Sunami

2022

Handbook of Stem Cell Therapy

View full text Add to dashboard Cite

Potentialités et intérêt du tissu adipeux dans la sclérodermie

Cited by 12 publications

References 56 publications

Locoregional Treatments for Digital Ulcers in Systemic Sclerosis: A Systematic Review

Locoregional Treatments for Digital Ulcers in Systemic Sclerosis: A Systematic Review

Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis

Adipose tissue-derived regenerative cell-based therapies: Current optimisation strategies for effective treatment in aesthetic surgery

Contact Info

Product

Resources

About